Domino 10 introduces several new features that administrators should prepare for including implementing a JavaScript framework, learning Docker, and updating development tools. It also advises preparing applications by adding templates to source control, finding quick wins, and eliminating unused code. Additionally, administrators are advised to learn skills like JSON, CentOS, and OAuth to take advantage of Domino 10's new capabilities like support for Node.js, a new query language, and HTTP 2.0 support.