COPD is the 6th leading cause of death worldwide characterized by narrowing of airways. The two main types are chronic bronchitis, involving inflammation of the airways, and emphysema, involving enlargement of airspaces in the lungs. Smoking is the primary cause. Diagnosis involves spirometry showing reduced airflow and imaging may be used. Treatment focuses on reducing risk factors, managing stable COPD and exacerbations, and addressing comorbidities through bronchodilators, steroids, oxygen therapy, pulmonary rehabilitation, and occasionally surgery.
2. COPD
6th
leading cause of death worldwide
Prevalence- ~5%
Chronic progressive lung disease
Characterized by narrowing of airways
Partially reversible, unlike asthma
Commonly associated with smoking
Cause SOB & cough with expectoration
Diagnosis requires PFT
3. Types
Chronic bronchitis
Cough with sputum production on most days for 3 months of a year, for
2 consecutive years
Hyperplasia & hypertrophy of goblet cells & mucous glands, with
inflammation of the airways
Progression causes metaplasia & fibrosis
Advanced disease causes cyanosis & fluid retention- blue bloater
Emphysema
Permanent enlargement of air-spaces distal to terminal bronchioles,
leading to reduced surface area for exchange of gases
Elasticity of lungs is reduced
Patient makes effort to breathe giving looks of pink puffer
9. Treatment
Bronchodilators- relax smooth-muscle around
airways, providing an improved quality of life
Given as inhalers
Anticholinergics- Tiotropium, Ipratropium
Beta-agonists- Salmeterol/Formoterol, Salbutamol
Oral Theophylline
Steroids- inhaled or oral, to treat & prevent
acute exacerbations in those with moderate
or severe COPD
10. Treatment- severity
Mild- short-acting bronchodilator SOS
Moderate- regular long-acting
bronchodilators
Severe- +inhaled steroids, oral steroids
for acute exacerbations
Very severe- +LTOT, ± regular oral
steroids
11. Long-term oxygen therapy
For moderate or severe COPD
Need based on ABG, on 2 occasions, at least
3 weeks apart, in patient with stable COPD,
on optimum medical treatment
Indications-
PaO2 <55 mm Hg or SaO2 <88% on RA
PaO2 55-59 mm Hg with dependent edema/Hct >56%/PHT
Nocturnal hypoxemia
Duration- >15 hours a day, longer is better
12. Surgery
Bullectomy, for bulla encompassing >30% of
a hemithorax
Lung volume reduction surgery- only for
upper lobe emphysema
Lung transplantation-
FEV1 <25% predicted
Resting RA PaCO2 >55 mm Hg
Elevated PaCO2 with need for LTOT
Elevated pulmonary artery pressure with progressive
deterioration
13. Management of exacerbation
Acute sustained worsening of
symptoms
Check CxR, ABG, CBC, sputum culture
Treatment-
Short-acting inhaled bronchodilators
Prednisolone, 30 mg OD X 7-14 days
Supplemental oxygen to keep SaO2 >90%
Empiric antibiotics, if sputum purulent x 7 days
IV Theophylline, as adjunct to bronchodilators
Non-invasive or invasive ventilation
14. Prognosis
COPD is a progressive disease
Poor prognostic markers are-
Severe airflow obstruction
Poor exercise capacity
Severe SOB
Significantly over/underweight
Respiratory failure or cor pulmonale
Continued smoking
Frequent acute exacerbations