ComRAD is an intelligent information and expert system developed using the universal methodology of computerized system analysis and design (MCAD). It is part of a nationwide intelligent information and expert system environment. ComRAD uses a universal knowledge base (KB) and operating data base (ODB) that are parts of the CoSMoS e-technology platform. The KB includes scientific and standardized medical knowledge, while the ODB contains unified patient medical records. ComRAD is designed to provide optimal treatment recommendations and variants to medical specialists based on comparisons between patients' conditions and normal characteristics in the KB.