This document discusses compressed and damaged newborn bloodspot screening cards, which can cause problems for laboratories analyzing the samples. Compressed cards may be incomplete dried, scratched, abraded, ridged, or damaged by liquid. This can affect the laboratory's ability to obtain a sufficient sample from the card using a punch, as compressed areas will not contain the same amount of blood as undamaged areas. A tiny amount of missing blood could cause a baby with a positive screening result to be missed. It is important for cards to dry completely before sealing in envelopes and to notify the laboratory of any wet or damaged cards.