Cognition Assessment Batteries for Phase II Studies in Alzheimer’s Disease by Cognitive Domain

1. Cognition Assessment Batteries for Phase II Studies in Alzheimer’s Disease by Cognitive Domain
Cognitive domain 15-item ADAS-Cog NTB subtest (3) ADNI subtest CDR System subtest (4) CogState subtest (5) CANTAB subtest (6) CHMP guideline
subtest (1, 2) www.adni-info.org www.cognitivedrugresear www.cogstate.com www.cambridgecognition www.emea.europa.eu/pd
ch.com .com fs/human/ewp/055395en
.pdf
Episodic verbal memory Immediate Word Recall, RAVLT Immediate Word Logical memory Immediate Word Recall, One word learning, Verbal recognition Recall and recognition
Recall, Immediate, memory, memory (verbal)
Delayed Word Recall, Delayed Word Recall, ISLT immediate recall, (“learning of new
RAVLT Delayed Word Logical Memory Delayed, (Graded naming test) material”)
Word Recognition, Recognition/Recall Word recognition, ISLT delayed recall
(combined), AVLT Word Recognition, Quality of episodic
Remembering test memory (composite)
instructions, Verbal PAL Immediate, RAVLT Delayed Word
Orientation Recall,
Verbal PAL Delayed
RAVLT Word Recognition
Episodic visual memory - Visual PAL Immediate, - Picture recognition, One card learning, Delayed matching to Recall and recognition
Quality of episodic sample, memory (visuo-spatial)
Visual PAL Delayed memory (composite) Groton maze learning (“learning of new
delayed Paired associates learning, material”)
Pattern recognition
memory,
Spatial recognition
memory
Praxis Constructional praxis, - Clock drawing - - - Constructional ability
Ideational praxis
Semantic memory Object/finger naming - Boston naming test - - Graded naming test “remote as well as recent
memory”
Language Spoken language ability, - - - - - Language
Word finding difficulty,
Comprehension of spoken
language,
Following commands
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2. Cognition Assessment Batteries for Phase II Studies in Alzheimer’s Disease by Cognitive Domain
Attention Concentration/ - Digit symbol substitution Simple reaction time; Identification task, Choice reaction time, Attention/ concentration
distractibility,
Choice reaction time; Monitoring task Rapid visual information
Digit cancellation processing,
Digit vigilance,
Continuity of attention Match to sample visual
(composite) search
Working memory - Digit span Digit span Numeric working memory, One back and two back Spatial span, Not specified
Spatial working memory, tasks
Quality of working Spatial working memory
memory (composite)
Executive function Executive maze Letter fluency, Category fluency, - Groton maze learning Intra/ extra dimensional Not specified
set shift,
Category fluency Trails B
One touch stockings of
Cambridge,
Stockings of Cambridge
Psychomotor speed - - Trails A Power of attention Detection task, Reaction time, Psychomotor speed
(composite),
Speed of memory Chase test Simple reaction time
(composite)
References
1. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984 Nov;141(11):1356-64.
2. Mohs RC, Knopman D, Petersen RC, Ferris SH, Ernesto C, Grundman M, et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that
broaden its scope. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S13-21.
3. Harrison J, Minassian SL, Jenkins L, Black RS, Koller M, Grundman M. A neuropsychological test battery for use in Alzheimer disease clinical trials. Arch Neurol. 2007 Sep;64(9):1323-9.
4. Simpson PM, Surmon DJ, Wesnes KA, Wilcock GR. The cognitive drug research computerised assessment system for demented subjects: A validation study. International Journal of Geriatric Psychiatry. 1991;6:95-102.
5. Maruff P, Collie A, Darby D, Weaver-Cargin J, Masters C, Currie J. Subtle memory decline over 12 months in mild cognitive impairment. Dement Geriatr Cogn Disord. 2004;18(3-4):342-8.
6. Egerhazi A, Berecz R, Bartok E, Degrell I. Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Apr 13;31(3):746-51.
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