This document discusses the Western Cape Provincial Government's cluster program for economic development. It provides a history of the program since 1998 and outlines the current portfolio of 16 industry clusters. It then describes the nature of the cluster initiatives, the roles of the provincial government and lessons for the national government. Finally, it discusses key challenges for emerging and mature cluster programs and concludes that the Western Cape's broad-based cluster program has provided a platform to build industry networks and encourage economic restructuring.