A presentation on May 7th 2015 at the Epigenomics Journal Club we had started.
This one comprises the main papers looking at Alzheimer's Disease and the immuno-cell specific signatures shown in the mice models.
A complementary study in patients found ANK1 as a clear EWAS association.
A reading report for <A Secreted Slit2 Fragment Regulates Adipose Tissue Ther...星云 王
A reading report for <A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
>, only for private study use, please do not use it for profit or public.
G Protein Coupled Receptor- An Introduction.Arindam Sain
The Largest family of integral membrane protein involved in many biological process and pathologies. 50% of all modern drugs and 25% of the top 200 best selling drugs are estimated to target GPCRs. Transduce the signals mediated by diverse signaling molecules, such as ions, peptides, lipids and photons, to induce different intracellular function. Bind their ligand and toa activate different G proteins.
Buscamos que los Estudiantes conozcan que es "Audacity"-- Created using PowToon -- Free sign up at http://www.powtoon.com/ -- Create animated videos and animated presentations for free. PowToon is a free tool that allows you to develop cool animated clips and animated presentations for your website, office meeting, sales pitch, nonprofit fundraiser, product launch, video resume, or anything else you could use an animated explainer video. PowToon's animation templates help you create animated presentations and animated explainer videos from scratch. Anyone can produce awesome animations quickly with PowToon, without the cost or hassle other professional animation services require.
A reading report for <A Secreted Slit2 Fragment Regulates Adipose Tissue Ther...星云 王
A reading report for <A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
>, only for private study use, please do not use it for profit or public.
G Protein Coupled Receptor- An Introduction.Arindam Sain
The Largest family of integral membrane protein involved in many biological process and pathologies. 50% of all modern drugs and 25% of the top 200 best selling drugs are estimated to target GPCRs. Transduce the signals mediated by diverse signaling molecules, such as ions, peptides, lipids and photons, to induce different intracellular function. Bind their ligand and toa activate different G proteins.
Buscamos que los Estudiantes conozcan que es "Audacity"-- Created using PowToon -- Free sign up at http://www.powtoon.com/ -- Create animated videos and animated presentations for free. PowToon is a free tool that allows you to develop cool animated clips and animated presentations for your website, office meeting, sales pitch, nonprofit fundraiser, product launch, video resume, or anything else you could use an animated explainer video. PowToon's animation templates help you create animated presentations and animated explainer videos from scratch. Anyone can produce awesome animations quickly with PowToon, without the cost or hassle other professional animation services require.
A teaser for an upcoming new course in Bayesian Statistics.
Based in the great book and materials by Allen Downey (Olin College), "Think Bayes".
https://sites.google.com/site/simplebayes/
The book (and presentation) is under a Creative Commons Noncommercial license, so classroom presentations are totally fine.
Mitigating Infectious Disease - Opportunities and Awareness for Permaculture ...Susan Cousineau
A 45-minute talk that I gave to an international development Permaculture Design Certificate course, highlighting some of the risks and opportunities in using permaculture (and related practices) to reduce or amend infectious disease risks. Also highlights some risks that people may inadvertently increase for themselves and others, e.g. creating standing water bodies as vector habitat; increasing contact between wildlife and livestock.
Las creencias están en tu inconsciente, son filtros internos que están muy arraigados en ti, son todas tus convicciones, fronteras que están en tu mente y por lo tanto, las creencias son la verdad en tu vida, son lo que determinan tu mundo.
Descubre que tipo de creencias tienes, si son creencias que te potencializan o por el contrario creencias que te están limitando.
Consumer, business and digital marketing trends in sub-Saharan Africa for 2016 and beyond. Covers the emerging African middle class, cultural diversity, Pan-Africa migration, smartphone penetration, social networking popularity and social commerce. Rich with data, anecdotes, examples and inspiration thought-starters. **Note: bold text is hyperlinked to references and more information so click throughout :)
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
A teaser for an upcoming new course in Bayesian Statistics.
Based in the great book and materials by Allen Downey (Olin College), "Think Bayes".
https://sites.google.com/site/simplebayes/
The book (and presentation) is under a Creative Commons Noncommercial license, so classroom presentations are totally fine.
Mitigating Infectious Disease - Opportunities and Awareness for Permaculture ...Susan Cousineau
A 45-minute talk that I gave to an international development Permaculture Design Certificate course, highlighting some of the risks and opportunities in using permaculture (and related practices) to reduce or amend infectious disease risks. Also highlights some risks that people may inadvertently increase for themselves and others, e.g. creating standing water bodies as vector habitat; increasing contact between wildlife and livestock.
Las creencias están en tu inconsciente, son filtros internos que están muy arraigados en ti, son todas tus convicciones, fronteras que están en tu mente y por lo tanto, las creencias son la verdad en tu vida, son lo que determinan tu mundo.
Descubre que tipo de creencias tienes, si son creencias que te potencializan o por el contrario creencias que te están limitando.
Consumer, business and digital marketing trends in sub-Saharan Africa for 2016 and beyond. Covers the emerging African middle class, cultural diversity, Pan-Africa migration, smartphone penetration, social networking popularity and social commerce. Rich with data, anecdotes, examples and inspiration thought-starters. **Note: bold text is hyperlinked to references and more information so click throughout :)
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
37. + Clinical biomarkers with diagnostic and prognostic utility during AD-development.
+ Pre-mortem whole-blood DNA from the discovery cohort (n=57).
+ Duration between blood sampling and mortality (avg = 4.15 ± 3.00 years).
+ Analyses restricted to identification of DMPs associated with clinical diagnosis of AD instead of Braak score.
+ Identify a number if AD-associated DMPs, many in the vicinity of relevant to AD genes (e.g. DAPK1, GAS1, NDUFS5).
+ However, the top-ranked DMPs in blood are distinct from those identified in the brain as they show no significant overlap with either
cortex or CER.
+ AD-associated DMPs in blood are unlikely related to the actual neurodegenerative process.
+ However, using previous blood-based transcriptomic data (ref. 38), they observe 18 of their top-ranked blood DMPs located in the vicinity
of known differentially expressed transcripts.
40. Gjoneska et al. Lunnon et al. 2015
• Contrasting changes in immune and
neuronal genes and regulatory regions
during AD-like degeneration
• Surprising depletion of neuronal
promoters and enhancers for a cognitive
disorder with well-established
connections to environmental and
experiential factors
• Model of interactions between genetically
driven immune cell dysregulation and
environmentally driven epigenetic
alteration in neural cells
• Power of the CK-p25 mouse model for the
study of AD human disease progression.
Molecular changes in both genes and
regulatory regions are highly conserved.
• Specific therapeutic targets for AD (e.g.
PU.1)
• Largest cross-tissue study of AD using matched DNA
from both affected and unaffected brain regions.
First sequential replication with 3 independent
study cohorts and 2 independent technologies.
• Cortex-specific hypermethylation across an ANK1
region in several independent cohorts suggestive of
the locus being relevant to AD-pathogenesis. Most
substantial in EC. Replication of the same DMR in
another large EWAS of AD (De Jager et al.).
• Most brain-identified DMPs, including ANK1, not
detected in blood. But many DMPs in blood located
in vicinity of genes found altered in patients with
MCI.
• Careful control of technical artefacts in EWAS with
Illumina 450K array.
• Power calculations from EWAS in study design. They
state to be powered to identify relatively small
(~5%) DNA methylation differences between
groups.
• Conventional methods for multiple-test correction
likely to be overly stringent and inappropriate given
non-independence of loci and lack of inter-
individual variation.