S8 Smalltalk allows objects to run on different computational platforms and interact transparently across systems. It provides syntax extensions to access lower-level execution details when needed. S8 objects can utilize various APIs and run on platforms like Windows, Lua, and Android through a common foundation layer. This enables interaction between S8 systems running on different machines, like one on Windows/JavaScript, one on Windows/Lua, and one on Android. Developers can share code and resources across targets through the U8 universe repository.