2. Historical Background
• In 1755, Roederer first described congenital
choanal atresia; therefore, this condition
has been recognized for more than 200
years.
• .
4. • Rare congenital anomily
• 1 in 5000 to 8000 live births
• Female male ratio is 2:1
5. Epidemiology
• Occurs in ~1 in 5,000 – 7,000 live births
• More common in girls than boys
• Slightly increased risk exists in twins.
• Maternal age or parity does not increase the
frequency of occurrence.
6. • Chromosomal anomalies are found in 6%
of infants with choanal atresia.
•
• Choanal atresia occurs with equal
frequency in people of all races
10. Etiology
• By the 38th day of development, the 2-layer
membrane consisting of nasal and oral epithelia
ruptures and forms the choanae (posterior nares).
11. • Failure of this rupture results in choanal
atresia.
• In 2008, Barbero et al suggested that
prenatal use of antithyroid (methimazole,
carbimazole) medications was linked to
choanal atresia.