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Cellular networks
Lars Juhl Jensen
molecular players
understand their interplay
useful abstraction
lends itself to visualization
why do I care?
string-db.org
functional associations
genome comparison
Korbel et al., Nature Biotechnology, 2004
experimental data
Jensen & Bork, Science, 2008
curated knowledge
text mining
>10 km
10,000+ users/week
gene set visualization
Jayaraman, Saudi J. Biol. Sci., 2015
ridiculogram
why is it so hard?
too much to show
100–1000 proteins
1000–10000 interactions
names
functional classes
regulation
subcellular localization
tissue expression
disease associations
modification sites
interaction types
direction
confidence scores
you cannot show it all
what is most important?
proteins
interactions
use different visualizations
you have to choose
proteins
distribute in 2D
force-directed layout
Szklarczyk et al., Nucleic Acids Research, 2017
clustering
intra-cluster interactions
parallel visualizations
interactions
distribute in 1D
protein identity
Himmelstein et al., Thinklab, 2016
open challenges
time courses
de Lichtenberg et al., Science, 2005
modification sites
Francavilla et al., Cell Reports, 2017
Thank you
Damian Szklarczyk
John
"Scooter" Morris
Helen Cook
Michael Kuhn
Stefan Wyder
Milan Simonovic
Alberto Santos
Nadezhda Donch
eva
Alexander Roth
Peer Bork
Christian von Meri
ng
Thank you
Thank you

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