Cell Physiology: Discuss the significance and ramifications of epigenetics and and the epigenome Solution The word epigenetics means above genetics means change in gene expression without changing the DNA sequence. all human cells carrying the same genetic information but still they are able to differentiate into different cell type and performing different kind of function so the genetic information must be express at a right time and right place for the normal devlopment of an organism this is regulated by various epigenetics mechanism like DNA methylation, Histone modification and RNA interference. Epigenomics is the study of complete set of epigentics modification like DNA methylation, Histone modification and RNA interference..