PEPFAR has significantly impacted HIV treatment and prevention, achieving notable milestones such as 14.6 million individuals on antiretroviral therapy and 2.4 million babies born HIV-free. The strategy focuses on transitioning program responsibilities to local partners, with a target of 70% funding to these partners by FY20, ensuring services are owned by local institutions. A recent $100 million investment aims to enhance HIV epidemic control through faith-based organizations, addressing key gaps and integrating community efforts against sexual violence affecting children.