Leiomyosarcoma (LMS) metastasis in the central nervous system is extremely rare. Metastatic LMSs have been described in the orbit, meninges, and skull base, however there are no reports of LMS metastasis into the cavernous sinuswith primary origin from lower extremity and long silent disease period of 7 years..
Primary malignant schwannoma is a rare neoplasm of nerve sheath origin. It is a cancer of the connective tissue surrounding nerves. Given its origin and behavior it is classifi ed as sarcoma. The estimated incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) in general population is 0.001% and in patients with Neurofi bromatosis 1 (NF-1) is 2-5%. It is an uncommon spindle cell sarcoma accounting for approximately 5% of all soft-tissue sarcoma. They are highly aggressive and occur in the second or third decade. This neoplasm usually affects the extremities. There is strong association between MPNSTs and neurofi bromatosis (NF-1) and previous irradiation. We present the case of a 61-year-old woman manifesting with recurrent sciatalgy near for the fourth and fi fth lumbar vertebral bodies. She underwent resection of a mass at the L4-5 level that was subsequently recognized as a malignant peripheral nerve sheath tumor.
Leiomyoma is a benign tumor that originates from smooth
muscle cell. The most common sites are the uterus, gastrointestinal tract & skin. Leiomyoma is a relatively uncommon smooth muscle tumor rarely found in the head and neck. Enzinger and Weiss (1995), analyzed a total of 7748 leiomyomas, 95% of the tumors occurred in the female genitalia (uterus), 3% in the skin, 0.9% in the gastrointestinal tract and the remainder at various sites including skull base.
The document summarizes various tumors and lesions that can occur in the cerebellopontine angle (CPA). The most common tumors are acoustic neuromas (schwannomas), which arise from the vestibular nerve. Other lesions include meningiomas, metastases, epidermoid tumors, dermoid cysts and lipomas. Imaging plays an important role in the diagnosis and treatment depends on the type and size of the lesion.
This document presents a case study of a 41-year-old female patient with mesenchymal chondrosarcoma. Biopsies found that she had mesenchymal chondrosarcoma in her left thigh and right shoulder. Mesenchymal chondrosarcomas are rare, accounting for less than 2% of chondrosarcomas. They typically occur in bone but can also develop in soft tissue. These tumors are aggressive and have a high rate of metastasis. This case illustrates the potential for mesenchymal chondrosarcomas to develop in multiple locations and recur over time.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
This document describes a case report of a 48-year-old female patient who presented with a large lipoma in her anterior neck region that extended into the mediastinum. Imaging including ultrasound, CT, and MRI confirmed a large fat-density mass measuring 16x14.8x13 cm involving the neck spaces and mediastinum. The patient underwent surgical excision of the giant lipoma, which weighed 1200 grams. Histopathology confirmed it was a lipoma. Lipomas are generally benign fatty tumors, but this case was unique due to the large size and mediastinal extension, which made surgical excision more challenging.
Primary malignant schwannoma is a rare neoplasm of nerve sheath origin. It is a cancer of the connective tissue surrounding nerves. Given its origin and behavior it is classifi ed as sarcoma. The estimated incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) in general population is 0.001% and in patients with Neurofi bromatosis 1 (NF-1) is 2-5%. It is an uncommon spindle cell sarcoma accounting for approximately 5% of all soft-tissue sarcoma. They are highly aggressive and occur in the second or third decade. This neoplasm usually affects the extremities. There is strong association between MPNSTs and neurofi bromatosis (NF-1) and previous irradiation. We present the case of a 61-year-old woman manifesting with recurrent sciatalgy near for the fourth and fi fth lumbar vertebral bodies. She underwent resection of a mass at the L4-5 level that was subsequently recognized as a malignant peripheral nerve sheath tumor.
Leiomyoma is a benign tumor that originates from smooth
muscle cell. The most common sites are the uterus, gastrointestinal tract & skin. Leiomyoma is a relatively uncommon smooth muscle tumor rarely found in the head and neck. Enzinger and Weiss (1995), analyzed a total of 7748 leiomyomas, 95% of the tumors occurred in the female genitalia (uterus), 3% in the skin, 0.9% in the gastrointestinal tract and the remainder at various sites including skull base.
The document summarizes various tumors and lesions that can occur in the cerebellopontine angle (CPA). The most common tumors are acoustic neuromas (schwannomas), which arise from the vestibular nerve. Other lesions include meningiomas, metastases, epidermoid tumors, dermoid cysts and lipomas. Imaging plays an important role in the diagnosis and treatment depends on the type and size of the lesion.
This document presents a case study of a 41-year-old female patient with mesenchymal chondrosarcoma. Biopsies found that she had mesenchymal chondrosarcoma in her left thigh and right shoulder. Mesenchymal chondrosarcomas are rare, accounting for less than 2% of chondrosarcomas. They typically occur in bone but can also develop in soft tissue. These tumors are aggressive and have a high rate of metastasis. This case illustrates the potential for mesenchymal chondrosarcomas to develop in multiple locations and recur over time.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
This document describes a case report of a 48-year-old female patient who presented with a large lipoma in her anterior neck region that extended into the mediastinum. Imaging including ultrasound, CT, and MRI confirmed a large fat-density mass measuring 16x14.8x13 cm involving the neck spaces and mediastinum. The patient underwent surgical excision of the giant lipoma, which weighed 1200 grams. Histopathology confirmed it was a lipoma. Lipomas are generally benign fatty tumors, but this case was unique due to the large size and mediastinal extension, which made surgical excision more challenging.
GIANT ANTERIOR NECK LIPOMA WITH MEDIASTINAL EXTENSIONAakanksha Rathor
This document describes a case report of a rare giant anterior neck lipoma with mediastinal extension in a 48-year-old female patient. The large lipoma mass measured 16x14.8x13 cm and extended from the neck into the anterior mediastinum. Imaging including ultrasound, CT scan, and biopsy confirmed the diagnosis of a benign lipoma. The entire lipoma weighing 1200 grams was surgically removed from the neck and mediastinum without complications. The patient recovered well and had no recurrence after 1 year of follow up.
1. The patient presented with a palatal swelling and MRI revealed another parotid lesion. Biopsies found polymorphous adenocarcinoma in the palate and pleomorphic adenoma in the parotid gland.
2. Both lesions were surgically removed. Post-operative radiation was recommended for the palatal tumor due to perineural invasion.
3. Having multiple salivary gland tumors is unusual but not unheard of. MRI proved useful for detecting the additional concealed parotid lesion in this case. Each tumor requires separate diagnosis and treatment.
The document discusses insular glioma surgery. It begins with an overview of the insular cortex anatomy and its relationship to surrounding vasculature. It then covers surgical approaches like the transsylvian and transcortical methods. Techniques like awake mapping and protective measures for critical vasculature are also outlined. The document emphasizes that maximal tumor resection improves survival outcomes for insular gliomas, especially with adjuvant technologies to aid resection. Complications can be minimized with meticulous technique when navigating this eloquent brain region.
Journal of Pathology & Microbiology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Pathology & Microbiology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Pathology & Microbiology. Journal of Pathology & Microbiology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of pathology & microbiology.
Journal of Pathology & Microbiology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Cervical Sympathetic chain ganglioneuroma : case report and review of literatureiosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Skull Metastasis From Papillary Thyroid Carcinoma : Case Report and Literatur...komalicarol
Although papillary thyroid carcinoma is a relatively common form of malignancy, metastatic spread to the skull
is exceptional. Here, we report a case of papillary thyroid carcinoma revealed by frontal skull metastasis.
Skull Metastasis from Papillary Thyroid Carcinoma: Case Report and Literature...semualkaira
Although papillary thyroid carcinoma is a relatively common form of malignancy, metastatic spread to the skull
is exceptional. Here, we report a case of papillary thyroid carcinoma revealed by frontal skull metastasis.
An Unusual Case of Secondary in Sphenoid Sinus from Carcinoma Prostate by George MV in Experiments in Rhinology & Otolaryngology
https://crimsonpublishers.com/ero/fulltext/ERO.000518.php
Spinal cord lesions and its radiological imaging finding.Navneet Ranjan
1. The document discusses imaging approaches for evaluating intramedullary spinal cord lesions. It outlines a systematic approach including assessing the lesion length, extent of cord involvement, location within the cord, cord swelling, and enhancement characteristics.
2. Differential diagnoses discussed include demyelinating diseases, tumors, vascular causes, and infections. Specific conditions like multiple sclerosis, neuromyelitis optica, transverse myelitis, and various tumor types are described.
3. Imaging features of different pathologies are provided to help differentiate between conditions like ependymoma, astrocytoma, ganglioglioma, and hemangioblastoma.
— Superior orbital fissure syndrome (SOFS) is a rare disease. So when a case of this came at Aravind Eye Institute, a detailed case report was prepared to publish. A 56 years old male patient, a known case of prostatic malignancy with skeletal metastasis presented with ptosis, exotropia, diminished pupillary reflex and limitations in extraocular movements of left eye. MRI brain revealed diffuse skull base and leptomeningeal metastasis. Whole body CT scan showed metastasis in ribs, scapula and in pelvic bones. He was diagnosed to have superior orbital fissure syndrome due to metastatic prostatic malignancy and was offered steroids and radiotherapy.
This article describes the management of 6 male patients with soft tissue sarcoma (STS) treated outside of a sarcoma center. Five patients presented with slowly growing painless masses of long duration, while the youngest patient had bilateral lung metastases shortly after resection of a primitive neuroectoderm tumor in his thigh. Investigations included imaging and biopsies to determine diagnoses, which included rare tumors. Wide surgical excision was performed in 5 cases, while forequarter amputation was necessary in one case. Local recurrence occurred in 3 patients, who received additional treatment. The author concludes that patients with STS can be satisfactorily managed outside a sarcoma center if standard guidelines are followed and the surgical team has adequate experience.
This document summarizes a case report of a rare case of bilateral squamous cell carcinoma of the temporal bones in a 30-year-old male patient who presented with extensive late-stage disease. Imaging showed large lesions destroying bone structure in the right temporal bone and a smaller lesion in the left. Biopsy confirmed squamous cell carcinoma in both ears. The right-sided tumor was deemed unresectable and the patient received palliative radiotherapy, with a poor prognosis. Bilateral temporal bone cancer is exceptionally rare and this represents one of the few reported cases.
1. Falcine and parasagittal meningiomas arise from the falx cerebri and superior sagittal sinus respectively. They are classified based on their location and involvement of surrounding structures like the sinus.
2. Preoperative evaluation focuses on assessing the tumor's relationship to the superior sagittal sinus and collateral vein development, the extent of bone involvement, and presence of edema or brain invasion.
3. Treatment decisions depend on factors like symptoms, tumor growth rate, age and location. Observation may be appropriate for asymptomatic or slowly growing tumors while surgical resection is indicated if the tumor is symptomatic or growing rapidly.
Anemia is a common condition of cancer patients. This is because cancers cause inflammation that decrease red blood cell production. In addition, many chemotherapies are myelosuppressive, meaning they slow down the production of new blood cells by the bone marrow.
Drug Repurposing: Recent Advancements, Challenges, and Future Therapeutics fo...JohnJulie1
Cancer is a prime public health burden that accounts for approximately 9.9 million deaths worldwide. Despite recent advances in treatment regimen and huge capital investment in the pharmaceutical sector, there has been little success in improving the chances of survival of cancer patients.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...JohnJulie1
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Diagnostic Accuracy of Raised Platelet to Lymphocyte Ratio in Predicting Heli...JohnJulie1
Helicobacter Pylori (HP) infection is prevalent among patients with dyspepsia in developing countries with low socioeconomic status. The gold standard investigation is invasive method gastric biopsy through upper GI endoscopy, however non-invasive methods (stool for HP antigen) are not reliable up to the mark also need to wait for two weeks without symptomatic treatment. It is important to have a reliable, cost effective and easily accessible non-invasive marker to diagnose patients with H. pylori infection. Several non-invasive laboratory have been predicted in having the role in diagnosis of H.pylori infection. Therefore, the aim of our study was to determine the diagnostic accuracy of platelet to lymphocyte ratio in predicting H.Pylori infection in patients with dyspepsia.
IRF5 Promotes the Progression of Hepatocellular Carcinoma and is Regulated by...JohnJulie1
The IRF family of proteins involves in the tumor progression. However, but the functions of IRF5 in the tumorigenesis are largely unknown. Here, IRF5 was found to be up-regulated in hepatocellular carcinoma (HCC). Interfering with IRF5 inhibited the growth and tumorigenic ability of HCC cells.
•
Fibrous
•
Fibro glandular
•
Adipose (Fatty)
What is Tomosynthesis?
•
Is a 3 dimensional projection
•
Reduces overlapping tissue seen with 2D only
•
15 projections are taken with each combo exposure (7.5) (-7.5)
•
With an average breast (18*24) 3D dose is 1.34, combo is 2.56 Milligrey. (3 Milligrey FDA) (2D is 1.2
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaJohnJulie1
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers.
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Similar to Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital Extension along the Third Nerve, Mimicking Cavernous Sinus Meningioma
GIANT ANTERIOR NECK LIPOMA WITH MEDIASTINAL EXTENSIONAakanksha Rathor
This document describes a case report of a rare giant anterior neck lipoma with mediastinal extension in a 48-year-old female patient. The large lipoma mass measured 16x14.8x13 cm and extended from the neck into the anterior mediastinum. Imaging including ultrasound, CT scan, and biopsy confirmed the diagnosis of a benign lipoma. The entire lipoma weighing 1200 grams was surgically removed from the neck and mediastinum without complications. The patient recovered well and had no recurrence after 1 year of follow up.
1. The patient presented with a palatal swelling and MRI revealed another parotid lesion. Biopsies found polymorphous adenocarcinoma in the palate and pleomorphic adenoma in the parotid gland.
2. Both lesions were surgically removed. Post-operative radiation was recommended for the palatal tumor due to perineural invasion.
3. Having multiple salivary gland tumors is unusual but not unheard of. MRI proved useful for detecting the additional concealed parotid lesion in this case. Each tumor requires separate diagnosis and treatment.
The document discusses insular glioma surgery. It begins with an overview of the insular cortex anatomy and its relationship to surrounding vasculature. It then covers surgical approaches like the transsylvian and transcortical methods. Techniques like awake mapping and protective measures for critical vasculature are also outlined. The document emphasizes that maximal tumor resection improves survival outcomes for insular gliomas, especially with adjuvant technologies to aid resection. Complications can be minimized with meticulous technique when navigating this eloquent brain region.
Journal of Pathology & Microbiology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Pathology & Microbiology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Pathology & Microbiology. Journal of Pathology & Microbiology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of pathology & microbiology.
Journal of Pathology & Microbiology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Cervical Sympathetic chain ganglioneuroma : case report and review of literatureiosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Skull Metastasis From Papillary Thyroid Carcinoma : Case Report and Literatur...komalicarol
Although papillary thyroid carcinoma is a relatively common form of malignancy, metastatic spread to the skull
is exceptional. Here, we report a case of papillary thyroid carcinoma revealed by frontal skull metastasis.
Skull Metastasis from Papillary Thyroid Carcinoma: Case Report and Literature...semualkaira
Although papillary thyroid carcinoma is a relatively common form of malignancy, metastatic spread to the skull
is exceptional. Here, we report a case of papillary thyroid carcinoma revealed by frontal skull metastasis.
An Unusual Case of Secondary in Sphenoid Sinus from Carcinoma Prostate by George MV in Experiments in Rhinology & Otolaryngology
https://crimsonpublishers.com/ero/fulltext/ERO.000518.php
Spinal cord lesions and its radiological imaging finding.Navneet Ranjan
1. The document discusses imaging approaches for evaluating intramedullary spinal cord lesions. It outlines a systematic approach including assessing the lesion length, extent of cord involvement, location within the cord, cord swelling, and enhancement characteristics.
2. Differential diagnoses discussed include demyelinating diseases, tumors, vascular causes, and infections. Specific conditions like multiple sclerosis, neuromyelitis optica, transverse myelitis, and various tumor types are described.
3. Imaging features of different pathologies are provided to help differentiate between conditions like ependymoma, astrocytoma, ganglioglioma, and hemangioblastoma.
— Superior orbital fissure syndrome (SOFS) is a rare disease. So when a case of this came at Aravind Eye Institute, a detailed case report was prepared to publish. A 56 years old male patient, a known case of prostatic malignancy with skeletal metastasis presented with ptosis, exotropia, diminished pupillary reflex and limitations in extraocular movements of left eye. MRI brain revealed diffuse skull base and leptomeningeal metastasis. Whole body CT scan showed metastasis in ribs, scapula and in pelvic bones. He was diagnosed to have superior orbital fissure syndrome due to metastatic prostatic malignancy and was offered steroids and radiotherapy.
This article describes the management of 6 male patients with soft tissue sarcoma (STS) treated outside of a sarcoma center. Five patients presented with slowly growing painless masses of long duration, while the youngest patient had bilateral lung metastases shortly after resection of a primitive neuroectoderm tumor in his thigh. Investigations included imaging and biopsies to determine diagnoses, which included rare tumors. Wide surgical excision was performed in 5 cases, while forequarter amputation was necessary in one case. Local recurrence occurred in 3 patients, who received additional treatment. The author concludes that patients with STS can be satisfactorily managed outside a sarcoma center if standard guidelines are followed and the surgical team has adequate experience.
This document summarizes a case report of a rare case of bilateral squamous cell carcinoma of the temporal bones in a 30-year-old male patient who presented with extensive late-stage disease. Imaging showed large lesions destroying bone structure in the right temporal bone and a smaller lesion in the left. Biopsy confirmed squamous cell carcinoma in both ears. The right-sided tumor was deemed unresectable and the patient received palliative radiotherapy, with a poor prognosis. Bilateral temporal bone cancer is exceptionally rare and this represents one of the few reported cases.
1. Falcine and parasagittal meningiomas arise from the falx cerebri and superior sagittal sinus respectively. They are classified based on their location and involvement of surrounding structures like the sinus.
2. Preoperative evaluation focuses on assessing the tumor's relationship to the superior sagittal sinus and collateral vein development, the extent of bone involvement, and presence of edema or brain invasion.
3. Treatment decisions depend on factors like symptoms, tumor growth rate, age and location. Observation may be appropriate for asymptomatic or slowly growing tumors while surgical resection is indicated if the tumor is symptomatic or growing rapidly.
Similar to Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital Extension along the Third Nerve, Mimicking Cavernous Sinus Meningioma (14)
Anemia is a common condition of cancer patients. This is because cancers cause inflammation that decrease red blood cell production. In addition, many chemotherapies are myelosuppressive, meaning they slow down the production of new blood cells by the bone marrow.
Drug Repurposing: Recent Advancements, Challenges, and Future Therapeutics fo...JohnJulie1
Cancer is a prime public health burden that accounts for approximately 9.9 million deaths worldwide. Despite recent advances in treatment regimen and huge capital investment in the pharmaceutical sector, there has been little success in improving the chances of survival of cancer patients.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...JohnJulie1
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Diagnostic Accuracy of Raised Platelet to Lymphocyte Ratio in Predicting Heli...JohnJulie1
Helicobacter Pylori (HP) infection is prevalent among patients with dyspepsia in developing countries with low socioeconomic status. The gold standard investigation is invasive method gastric biopsy through upper GI endoscopy, however non-invasive methods (stool for HP antigen) are not reliable up to the mark also need to wait for two weeks without symptomatic treatment. It is important to have a reliable, cost effective and easily accessible non-invasive marker to diagnose patients with H. pylori infection. Several non-invasive laboratory have been predicted in having the role in diagnosis of H.pylori infection. Therefore, the aim of our study was to determine the diagnostic accuracy of platelet to lymphocyte ratio in predicting H.Pylori infection in patients with dyspepsia.
IRF5 Promotes the Progression of Hepatocellular Carcinoma and is Regulated by...JohnJulie1
The IRF family of proteins involves in the tumor progression. However, but the functions of IRF5 in the tumorigenesis are largely unknown. Here, IRF5 was found to be up-regulated in hepatocellular carcinoma (HCC). Interfering with IRF5 inhibited the growth and tumorigenic ability of HCC cells.
•
Fibrous
•
Fibro glandular
•
Adipose (Fatty)
What is Tomosynthesis?
•
Is a 3 dimensional projection
•
Reduces overlapping tissue seen with 2D only
•
15 projections are taken with each combo exposure (7.5) (-7.5)
•
With an average breast (18*24) 3D dose is 1.34, combo is 2.56 Milligrey. (3 Milligrey FDA) (2D is 1.2
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaJohnJulie1
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers.
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Skeletal muscle channelopathy are rare heterogeneous episodic disorders with marked genotypic and phenotypic variability resulting in periodic paralysis, and falls in young people which often misdiagnosed or undiagnosed due to its rarity, often the symptoms are miscommunicated to the treating phycision due to its episodic nature and not uncommonly physical examination by the time patient attend the clinic or hospital will be unremarkable apart from periodic muscle paralysis where patient will presented to ED with flaccid weakness,
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Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital Extension along the Third Nerve, Mimicking Cavernous Sinus Meningioma
1. Clinics of Oncology
ISSN: 2640-1037
Case Presentation
Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital
Extension along the Third Nerve, Mimicking Cavernous Sinus
Meningioma
Muhammad S*
Department of Neurosurgery, University Hospital Helsinki, Topeliuksenkatu 5, Helsinki, P.O. Box 266 FI-00029 HUS, Finland
2. Keywords
Leiomyosarcoma; Metastasis;
Cavernous sinus; Orbital
1. Abstract
Background: Leiomyosarcoma (LMS) metastasis in the central nervous system is extremely
rare. Metastatic LMSs have been described in the orbit, meninges, and skull base, however there
are no reports of LMS metastasis into the cavernous sinuswith primary origin from lower extrem-
ity and long silent disease period of 7 years.
Case presentation: We present a case of a 75-year-old woman with complaints of diplopia
for three months. An MRI scan revealed a contrast-enhancing lesion in the cavernous sinus,
extending along the third nerve through the left superior orbital fissure. In 2011, the patient was
diagnosed with and treated for a leiomyosarcoma of the left lower limb. The lesion mimicked a
meningioma in the MRI scan; intraoperatively, it appeared as a schwannoma of the third nerve.
The tumor was biopsied and partially resected, and the third nerve was decompressed. Radio
surgical treatment was recommended for the remaining tumor. We use an instructional intraop-
erative video to demonstrate the radiological and intraoperative aspects of LMS metastasis.
Conclusion:LMS can metastasize to the cavernous sinus, leading to varying degrees of oph-
thalmoplegia. Radio logically, metastatic LMS mimics a meningioma; intraoperatively, it mimics
a schwannoma.
3. Introduction
The metastasis of primary lung, breast and skin cancers is most
commonly detected in the brain. Other peripheral tumors, in-
cluding those from the gastrointestinal and urogenital tract,
rarely metastasize in the brain. Similarly, leiomyosarcoma (LMS)
metastasis in the central nervous system is extremely rare[1-8].
Although metastatic LMSs have been described in the orbit, me-
ninges and skull base[1-14], they have not been reported from the
lower extremity in the cavernous sinus. There are several reports
of LMSs in the cavernous sinus, however they were not distant
metastases – the LMS originated from vascular smooth muscles
in the cavernous sinus[8,10,13,15,16]. Here, we report the first
case of cavernous sinus LMS metastasis extending through the
superior orbital fissure along the third nerve, appearing radio
logically as a cavernous sinus meningioma and intraoperatively
as a schwannoma of the third nerve.
4. Case Report
A 75-year-old woman presented with third nerve palsy, expe-
riencing diplopia for three months. Upon examination, the pa-
tient was alert and oriented. Visual field was intact, and pupil
size was normal and reactive to light. The patient’s hearing and
facial nerve function were normal. In 2011, the patient received
surgical treatment of the leiomyosarcoma on her left lower leg.
An MRI scan revealed a contrast-enhancing space-occupying le-
sion in the left wall of the cavernous sinus, extending through
the superior orbital fissure along the third nerve (Figure 1 A-E).
No other pathology in the supra or infra-tentorial regions was
observed.
*Corresponding Author (s): Sajjad Muhammad, Department of Neurosurgery, Univer-
sity Hospital Helsinki, Topeliuksenkatu 5, Helsinki, P.O. Box 266, FI-00029 HUS, Fin-
land, Tel: 35503757488; Fax +358 9 471 87560; E-mail:ext-sajjad.muhammad@hus.fi
clinicsofoncology.com
Citation: ZMuhammad S, Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital Extension along the
Third Nerve, Mimicking Cavernous Sinus Meningioma. Clinics of Oncology. 2019; 1(7):1-3.
Volume 2 Issue 1- 2019
Received Date: 18 Apr 2019
Accepted Date: 18 May2019
Published Date: 25 May 2019
3. Volume2 Issue 1 -2019 Case Presentation
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