This 44-year-old male presented with progressive shortness of breath for one week. He had a history of weight loss, cough, and poor appetite. Physical examination revealed decreased skin turgor and crepitations on chest palpation. Chest X-ray and CT scan showed cavitary pulmonary tuberculosis with pneumothorax. Sputum tests were positive for Mycobacterium tuberculosis. The patient was diagnosed with pulmonary tuberculosis, acute respiratory failure, septic shock, and complications of pneumothorax and pneumomediastinum. He required intubation and mechanical ventilation in the intensive care unit.