Pex and Moles are unit testing tools for .NET that allow automatically generating test cases (Pex) and replacing .NET methods with mocks (Moles). Pex uses a constraint solver to systematically generate inputs that achieve high code coverage with minimal tests. Moles provides two types of mocking: stub types for virtual methods, and mole types that rewrite code at runtime but have performance overhead. The document discusses these tools and how they can help with isolating dependencies in unit tests.