CardioNXT’s RADAR Clinical Trial Addresses Unmet AF Patient Need

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Sanjiv Narayan (Abbott)

Healthcare

CardioNXT’s RADAR Clinical Trial Addresses Unmet
AF Patient Need
A pioneering cardiologist in the area of atrial fibrillation (AF) care, Sanjiv M. Narayan, MD, PhD,
has a research focus on cardiac electrophysiology at Stanford University and previously at the
University of California in San Diego. He successfully developed the first system to map AF drivers
(the FIRM, Focal Impulse and Rotor Modulation platform), which combines computational analysis
and panoramic mapping in pinpointing exact AF electrical sources within heart tissue. The
accuracy of this work has been validated by optical mapping in human hearts. Dr. Sanjiv M.
Narayan’s work has led to several growth companies in the AF treatment sphere, including
CardioNXT.

CardioNXT’s RADAR Clinical Trial Addresses Unmet
AF Patient Need
CardioNXT is developing a product platform that will provide an improved understanding of AF and
other cardiac arrhythmias, and enable targeted therapies to be delivered to impacted heart regions.
Committed to reducing treatment costs, CardioNXT has an aim of enabling global adoption in
underserved emerging markets.

CardioNXT’s RADAR Clinical Trial Addresses Unmet
AF Patient Need
In 2018, CardioNXT launched the fully enrolled clinical trial Real-time electrogram Analysis for
Drivers of Atrial fibRillation (RADAR). Involving the participation of 65 individuals, the study
focuses on patients being treated for persistent and long-standing persistent atrial fibrillation.

CardioNXT’s RADAR Clinical Trial Addresses Unmet
AF Patient Need
Within the scope of the trial, a new high resolution contact mapping technology is being tested for
efficacy in generating a heart image that cardiac electrophysiologists can easily make use of in
tailoring therapies for patients. As described by the director of Massachusetts General Hospital’s
AF program, the RADAR trial addresses a cardiac electrophysiology need that is unmet at present.

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Sanjiv M. Narayan, MD, PhD, is a California-based professor of medicine at Stanford University’s Arrhythmia Center. He previously spent 13 years as a professor of medicine at the University of California, San Diego. In addition to his work as a professor, Sanjiv Narayan, MD, PhD, has trained as a cardiologist and established himself as a member of professional organizations such as the Heart Rhythm Society. The Heart Rhythm Society (HRS) is a registered 501(c)(3) non-profit organization operating internationally. Founded in 1979, the organization has established several professional publications as a means of sharing information with medical professionals around the world. The Heart Rhythm Journal serves as the organization’s official medical journal. Non-members can subscribe to the journal at heartrhythmjournal.org, while HRS members have complimentary access to both print and online versions of the magazine. In addition to the magazine, readers can enhance their engagement with relevant topics through the monthly Heart Rhythm Podcast, hosted by editor-in-chief Dr. Peng-Sheng Chen. The podcast features interviews with article writers. The Cardiovascular Digital Health Journal, meanwhile, is a peer-reviewed, open-access journal with a specific focus on how digital medicine is changing the field of cardiology. The journal features an array of topics, all of which promote the ethical use of technologies and scientific data to better serve the more than 14 million Americans living with heart rhythm disorders. Additional HRS publications include Heart Rhythm O2, an online-only companion to Heart Rhythm Journal, and an archive of heart rhythm case reports, which can be accessed by HRS members at hrsonline.org.

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Former director of electrophysiology at the Veterans Affairs Medical Center in San Diego, Sanjiv M Narayan MD Ph.D. is currently a professor of medicine at Stanford University. Experienced cardiologist Sanjiv Narayan is a member of several groups and organizations, such as the Heart Rhythm Society (HRS). Formerly called the North American Society of Pacing and Electrophysiology (NASPE), the Heart Rhythm Society was founded in 1979 by four doctors. It is a non-profit international organization whose mission is to improve patient care through research, education, and optimal health care policies and standards. The HRS organizes several events, and from time to time holds awareness campaigns, the purpose of which is to shed more light on heart diseases. There are three familiar campaigns: Atrial Fibrillation Awareness Month Through its efforts during this campaign in September and throughout the year, the HRS works to increase public awareness of atrial fibrillation symptoms, warning signs, and treatments. Sudden Cardiac Arrest Awareness Month This is a Heart Rhythm Society initiative to raise awareness on sudden cardiac arrest. The campaign focuses on heart attack survivors, who are most at risk of sudden cardiac arrest, and emphasizes the importance of leading a healthy heart lifestyle. Arrest the Weak This multi-year national campaign was launched in October 2012. HRS made an effort to raise awareness of the importance of preventing sudden cardiac arrest, early intervention, and appropriate treatment to help reduce the mortality rate.

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Sanjiv Narayan (Abbott)

Sanjiv Narayan, Ph.D. is a practicing cardiologist who completed his MD at the University of Birmingham in the United Kingdom. A former director of electrophysiology at Veterans Affairs Medical Center in San Diego, Sanjiv M. Narayan serves as a professor of medicine at Stanford University in California. In his free time, he enjoys swimming, skateboarding, and cycling. Cycling is an activity or sport that involves riding a bicycle. Here are essential techniques every cyclist must use to improve efficiency: 1. Relax the upper body Stress in the body will gradually lead to discomfort and pain, and without feeling comfortable on the bike, the cyclist will eventually slow down. While tweaking position may help, relaxing the hands, elbows, and shoulders using a light grip on the handlebars makes over-corrections less likely. 2. Consider your aerodynamics Since cycling is essentially a fight against the wind, improving aerodynamics would boost efficiency. Spending more time cycling in the drops, wearing tight-fitted cycling clothes, and using aerodynamic devices like helmets and wheelsets are things that can help to slice through the wind effectively. 3. Use different hand positions Many cyclists often use one hand position than others. Although this technique is okay as long as they are comfortable with it, switching hand position is usually recommended. This technique helps prevent stiffness in the neck and back, and in some cases, helps to generate more power.

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Sanjiv M. Narayan, MD, PhD, is a cardiologist, a professor of medicine, and the director of electrophysiology research at Stanford University. He previously served as a professor of medicine at the University of California, San Diego. Dr. Sanjiv Narayan has pioneered therapies for atrial fibrillation that involved identifying localized regions or drivers, called Focal Impulse and Rotor Modulation, which is one of several 'AF Mapping" approaches to identify drivers now used in clinical practice.. Cardiac arrhythmia is a disorder that results in the heart beating irregularly, too slowly, or too quickly. The condition is caused by the malfunction of electrical impulses that coordinate or control the heartbeat. There are different types of cardiac arrhythmia, depending on the speed and the location in the heart they occur. Cardiac arrhythmia based on the rate of the heartbeat includes tachycardia and bradycardia. With tachycardia, the heart beats more than 100 times per minute. With bradycardia, the heart beats fewer than 60 times per minute. However, these heartbeat rates can occur in normal situations, such as exercise or sleep. They are a concern only when they are recurrent or they are a symptom of an underlying heart condition.

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Former professor of medicine at the University of California, San Diego, Sanjiv M. Narayan, MD, is a cardiologist and researcher in the field of cardiac electrophysiology. He serves as director of Electrophysiology Research at Stanford University and is currently developing the Stanford Arrhythmia Center. At the center, Sanjiv Narayan, PhD, intends to treat and research numerous cardiac afflictions, such as atrial fibrillation. Atrial fibrillation, or afib, is an irregular heartbeat caused by confusion in the electric signals to the heart. The daylight savings time (DST) change was identified as a potentially exacerbating factor for the condition based on research presented in 2018 at the American Heart Association Scientific Sessions. According to the research, people who are diagnosed with afib may be at a significantly increased risk of stroke during the period immediately following the springtime transition to DST. The data also showed that women may be disproportionately affected, and the risk was highest in women over the age of 65. StopAfib.org, an atrial fibrillation patient organization, has called for the end of the DST practice on the basis of this data.

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Cardiologist Sanjiv M. Narayan, MD, PhD, a graduate of the University of Birmingham in England, completed training in internal medicine at Mount Auburn Hospital/Harvard Medical School, then trained in cardiology/electrophysiology at Washington University. Sanjiv Narayan was then faculty at the University of California San Diego and director of electrophysiology at the Veterans Affairs Medical Center. Currently, he is at Stanford University and holds titles including co-Director of the Arrhythmia Center, Director of electrophysiological research and the atrial fibrillation program.

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Sanjiv M. Narayan, MD, PhD, is a Stanford cardiologist focused on developing novel approaches to the treatment of atrial fibrillation. Prior to becoming faculty at Stanford, Dr. Sanjiv Narayan spent more than a decade performing research in heart rhythm medicine at the University of California, San Diego. Today’s research in this field is largely focused of the application of modern technologies in the diagnosis and treatment of conditions like atrial fibrillation.

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Formerly an instructor at the University of California, San Diego, Sanjiv M. Narayan, MD, PhD, is a research cardiologist and Stanford University faculty member who has devoted his work to studying atrial fibrillation (abnormal heart rhythms). To further this work, he co-founded the Stanford Arrhythmia Center. Additionally, Dr. Sanjiv Narayan belongs to the Heart Rhythm Society, a professional organization dedicated to connecting and supporting health care providers who work with cardiac arrhythmia patients.

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