Canicul innundogy (goou) 427 , 30s-152 Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity Chun Kwok Wong a,1, Lydia Choi Wan Lit a,,1, Lai Shan Tam b, Chun Kwok Wong Edmund Kwok Ming Li "Bepartment of Chersical Aatholew The Chicese Univendey of Hone Kone, Arince of Walen haspitaf, Shatio, hone Ksong Fapa, Macau Aeceteed 19 suly 200?; accepted with revision 17 Janumry aocs dealable astine 25 Mirch 2008 Mbutract 1.-23-dependent. IL-17-producing T helper (T) bimphocyten are ansciated weth flaw cptonstry. Plannu IL-12, IL.17, 1.21 and CXCL 10 concentration and the number of Th17 cella were xignificantly welerwabed in 2 E patients than contsal a ubjects (bathp-a.as). Elovabed L12, 1-1T and CicLod concentrationa carrelated poetthely and signticanthy wath yeDa fall p-a.05). Flasu L-12 and L-1T ahowed aignificant and posthe cormblucion with plasu The chenolde CecL 10 concmination in sue pacionta (all pea.0s). Ex vire inductions of L-1J by (all p.0.00p. The activated L-21/L. 17 ash is inportate for the inflaminatary inmuntify in 21E. o 2 Dos elevier linc. All rights reourned. lntroduction T and 8 hymptocyten and aubiequent polyclonal actieation of circulating 8 bymphecytes that produces a large quatity Syaternic lupes erpthamateun (5LE) in a pratotypic vaternic of autareuctive artibodies [1]. it has been aureated that However, ether atualin hire dernasstrated that the Hong Kang Fax +1522632900 . immune respanes huve been gererally comidered to be C-nal addeus waskellumicutk edutk (C. W.K. Lamp. putholsical in autsinume dhease via the induction of inflammatery reaction [5]. 1321-Le16/5 - iee front rutber 6 ance thevier inc. Nill righta nearved.IL- 2.317 iw in SLE 387 Results and creatirine concentration, and druz treatment are urnmirhed in fable 1. Unitg a SLEDN citaff vcawa 6 , the SLE patients and ceetrol subjects praportians of the SLE graup and ISLE arap with active age-matched control sebjects piC group) werestudied. Their pyuria. The mein glamerulasephritis duration af isLL age, ses, deracian af dagninh, siephl icere, plasina urea putients was 6.6 yeirz. Plasma cytokines and chemokint Table 1 Characteritici of MSE and SE patinita and control Tubjuct. Phavna L-12, 1L-17, 1L-23 and CXCL10 cancentratiom were vigntica-tly higher in all SLE patiets as mel an lisLE and 2.E eroups thin in cortrol sebjocti (Table 2). Mil SLE patients huve devated plinma L-17 concertiration compared with centrol mbjocti. L-17 and Ciols thowed the freatentpind.06, data not thawniCirculating IL-17a secreting Titi cels Correlations between plasma IL-12, L-17 and Aashew in fie. 1, the number of circalating IL- 17i secesing CoLio Thil celh in 9 if patienta man vignica-tly higher than that PMA and ianernycin mere commorhy uned atinulators to carrelatiom of plinima IL-12 and IL-17 concertratiorn with actovate the expremion of IL-17 in Th1J cels accerding to CoCL.10 in FiF and SLE patienta.