The document discusses adjuvant treatment options for gastric cancer based on several clinical trials. It finds that adjuvant chemotherapy provides a 5.8% absolute benefit in 5-year overall survival compared to surgery alone. Adjuvant chemoradiotherapy may provide additional benefits for patients with D1 resections, lymph node ratios over 25%, or intestinal-type gastric cancers. Specifically, one trial found 5-year disease-free survival was 55% with chemoradiotherapy versus 28% with chemotherapy alone for these high-risk patients. The document concludes that adjuvant chemoradiotherapy should be considered for these poor prognosis patients when neoadjuvant treatment is not possible due to poor performance status.
This oral presentation made during ESMO 2016 highlight novel targets and drugs developed for patients with advanced neuroendocrine tumors. This includes targeted agents aiming probing cell signaling in tumor microenvironment and immune responses. Genetic alterations on major anti-oncogenes are reported in the perspective of pathway activations. Combinations using VEGFR, mTOR, Somatostatin receptors inhibitors with novel strategies and immunotherapy are also suggested. This presentation focuses mainly on gastrointestinal neuroendocrine tumors but may also be of interest for those involved in the care of patients with thoracic neuroendocrine tumors.
This oral presentation made during ESMO 2016 highlight novel targets and drugs developed for patients with advanced neuroendocrine tumors. This includes targeted agents aiming probing cell signaling in tumor microenvironment and immune responses. Genetic alterations on major anti-oncogenes are reported in the perspective of pathway activations. Combinations using VEGFR, mTOR, Somatostatin receptors inhibitors with novel strategies and immunotherapy are also suggested. This presentation focuses mainly on gastrointestinal neuroendocrine tumors but may also be of interest for those involved in the care of patients with thoracic neuroendocrine tumors.
Molecular testing and tumor testing. Have you ever been asked about it? Have you wondered the importance of it, as it relates to your particular cancer? Have you ever wondered if you should or shouldn't have your tumor tested, and what that involves? Dr. Bekaii-Saab, MD will discuss the importance of testing the molecular biology of an individual patients tumor. How they do that and why it may or may not be important to have done. He will talk about how this is playing an even bigger role in choice of treatment options for patients now more than ever. And about the way physicians are making treatment choices based on each individuals molecular biology of their tumor.
Dr. Bekaii-Saab is the Section Chief, Gastrointestinal Oncology, James Cancer Hospital and Solove Research Institute. Dr. Bekaii-Saab is one of America’s Best Doctors. Additionally, he has been listed in U.S. News and World Report’s Top Doctors for multiple consecutive years. His research interests include experimental therapeutics/translational research focused on molecularly-targeted and immune-mediated therapies in gastrointestinal (GI) cancers. He is the principal investigator on numerous clinical trials, including studies supported through research grants from the National Cancer Institute (NCI) and the National Comprehensive Cancer Network (NCCN). Dr. Bekaii-Saab is the recipient of the prestigious NCI clinical investigator team leadership award and the ASCO leadership program development award.
Alphabet Soup - Biomarker testing for colon and rectal cancer patients - KRAS...Fight Colorectal Cancer
Dr. Cathy Eng's presentation regarding biomarkers. Explaining why colon and rectal cancer patients should undergo testing for KRAS, NRAS and other tumor tests.
Molecular testing and tumor testing. Have you ever been asked about it? Have you wondered the importance of it, as it relates to your particular cancer? Have you ever wondered if you should or shouldn't have your tumor tested, and what that involves? Dr. Bekaii-Saab, MD will discuss the importance of testing the molecular biology of an individual patients tumor. How they do that and why it may or may not be important to have done. He will talk about how this is playing an even bigger role in choice of treatment options for patients now more than ever. And about the way physicians are making treatment choices based on each individuals molecular biology of their tumor.
Dr. Bekaii-Saab is the Section Chief, Gastrointestinal Oncology, James Cancer Hospital and Solove Research Institute. Dr. Bekaii-Saab is one of America’s Best Doctors. Additionally, he has been listed in U.S. News and World Report’s Top Doctors for multiple consecutive years. His research interests include experimental therapeutics/translational research focused on molecularly-targeted and immune-mediated therapies in gastrointestinal (GI) cancers. He is the principal investigator on numerous clinical trials, including studies supported through research grants from the National Cancer Institute (NCI) and the National Comprehensive Cancer Network (NCCN). Dr. Bekaii-Saab is the recipient of the prestigious NCI clinical investigator team leadership award and the ASCO leadership program development award.
Alphabet Soup - Biomarker testing for colon and rectal cancer patients - KRAS...Fight Colorectal Cancer
Dr. Cathy Eng's presentation regarding biomarkers. Explaining why colon and rectal cancer patients should undergo testing for KRAS, NRAS and other tumor tests.
Induction chemotherapy followed by concurrent ct rt versus ct-rt in advanced ...Santam Chakraborty
Small Presentation where the benefit of addition of induction / neoadjuvant chemotherapy to concurrent chemoradiation in head neck cancers is explored.
At Taste Of Middle East, we believe that food is not just about satisfying hunger, it's about experiencing different cultures and traditions. Our restaurant concept is based on selecting famous dishes from Iran, Turkey, Afghanistan, and other Arabic countries to give our customers an authentic taste of the Middle East
Key Features of The Italian Restaurants.pdfmenafilo317
Filomena, a renowned Italian restaurant, is renowned for its authentic cuisine, warm environment, and exceptional service. Recognized for its homemade pasta, traditional dishes, and extensive wine selection, we provide a true taste of Italy. Its commitment to quality ingredients and classic recipes has made it a adored dining destination for Italian food enthusiasts.
Piccola Cucina is regarded as the best restaurant in Brooklyn and as the best Italian restaurant in NYC. We offer authentic Italian cuisine with a Sicilian touch that elevates the entire fine dining experience. We’re the first result when someone searches for where to eat in Brooklyn or the best restaurant near me.
Ang Chong Yi Navigating Singaporean Flavors: A Journey from Cultural Heritage...Ang Chong Yi
In the heart of Singapore, where tradition meets modernity, He embarks on a culinary adventure that transcends borders. His mission? Ang Chong Yi Exploring the Cultural Heritage and Identity in Singaporean Cuisine. To explore the rich tapestry of flavours that define Singaporean cuisine while embracing innovative plant-based approaches. Join us as we follow his footsteps through bustling markets, hidden hawker stalls, and vibrant street corners.
Roti Bank Hyderabad: A Beacon of Hope and NourishmentRoti Bank
One of the top cities of India, Hyderabad is the capital of Telangana and home to some of the biggest companies. But the other aspect of the city is a huge chunk of population that is even deprived of the food and shelter. There are many people in Hyderabad that are not having access to
2. I: 12.1 por cada 100 000 hab
M: 8.9 por cada 100 000 hab
EPIDEMIOLOGÍA
INCIDENCIA: 5to lugar
MORTALIDAD: 2da causa
•> incidencia: Este de Asia, Sudamérica, Europa Oriental
•< Incidencia: EUA, Europa occidental.
6. 17 trials (3838 patients), median follow-up > 7 years
OS was 4.9 years in CX / 7.8 years in ADY QT
5 years CX ALONE 49.6%/ ADY QT 55.3%
10 years CX ALONE 37,5%/ ADY QT 44.9%
Absolute benefits were 5.8%
SG & SLE (HR 0.82)
18% reduction of risk of death with ADY QT
DFS The absolute benefit at 5 years was 5.3%, from 48.7% to 54.0%
JAMA, May 5, 2010—Vol 303, No. 17
7. Estimated 3-year DFS ADY CHEMO was 75%
DFS OBSERV was 60%
Estimated 5-year DFS ADY CHEMO was 68%
DFS OBSERV was 53%
Estimated 5-year SG ADY CHEMO was 78%
SG OBSERV was 69%
.
Lancet Oncol 2014; 15: 1389–96
ADY QT; DFS (HR 0.58)
ADY QT; SG (HR 0.66)
A randomised Phase III Trial
1035 patients, EC II, IIIA – IIIB, ECOG O – 2
D2 resection within 6 w before randomisation
END POINT: SLE a los 3 años, SG
Absolute benefits 15%
Absolute benefits 9%
34% reduction of risk of death
42% reduction of risk of recurrence disease
8. A randomised Phase III Trial
556 patients
ECOG O - 2
Histologically: Adenocarcinoma
R0 – D0 – D1 – D2 (10%)
EC: IB through IVM0
T 1–4
NODES 0, 1–3, >3
END POINT: SG, SLR
CHEMO (5FU 425 mg/m2/d and leucovorin, 20 mg/m2/d for 5
days): Days 1 - 5 after 28 days: CT_RT x 25 days
CHEMO-RT: 4500 cGy of radiation at 180 cGy/d 5 days/week for
5 weeks + 5FU 400 mg/m2/d and leucovorin, 20 mg/m2/d: Days
1 – 4 and 26 – 28 of RT
1 m after the completion of RT, 2 cycles of 5-day of 5FU (425
mg/m2/d) and leucovorin (20 mg/m2/d)
MacDonaldJS, et al. N EnglJ Med2001;345:725–730
CT+ CT-RT + CT
NO TREATMENT
SURGERY
SURGICAL PROCEDURES
54 (10%): D2 dissection.
199 (36%): D1 dissection
299 (54%): D0 dissection.
SLR 3y 48% VS 31%
SG 3y 50% VS 41%
THE ROLE OF RADIATION IN THE POSTOPERATIVE
SETTING: ADJUVANT
Absolute benefits 17% y 9%
12. PROGNOSTIC VALUE OF THE METASTATIC LYMPH NODE (N) RATIO IN THE ADJUVANT CHEMORADIOTHERAPY IN
STOMACH TUMORS (ARTIST) PHASE III TRIAL
The proportion between metastatic and examined
lymph nodes (N ratio): independent prognostic
factor in gastric cancer (GC) patients.
Methods: We retrospectively reviewed the data of
458 ARTIST patients who underwent D2 gastrectomy
followed by adjuvant chemotherapy with
capecitabine plus cisplatin (XP, n = 228) or
chemoradiotherapy (XPRT, n = 230).
Four N ratio categories (0% v 1-9% v 10-25% v >
25%) were employed, and statistical analysis was
performed using adjusted Cox regression and
stratified survival analysis.
Soonil Lee, Se Hoon Park, Jeeyun Lee, Won Ki Kang; Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, South Korea; Samsung Medical
Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Samsung Medical Center, Seoul, Korea, The Republic of; Division of Hematology-Oncology, Department of Medicine, Samsung
Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
ASCO, 2016 (suppl; abstr 4038)
Results:
At multivariate analysis, N ratio was retained as an
independent prognostic factor for DFS: HR for N ratio 0%, 1; N
ratio 1-9%, 1.061; N ratio 10-25%, 1.202; and N ratio > 25%,
3.571.
In patients with N ratio > 25%, the 5-year DFS was 55% v 28%
for XPRT and XP arms, respectively (HR, 0.527; 95% CI, 0.307
to 0.904; P = 0.020).
13. PHASE III trial,
788 patients, GASTRIC CA IB – III, ECOG 0, 1
D1 + lymph node dissection
END POINT: SG, SLE, toxicity profile and quality of life
Control arm: ECC x 3
Experimental arm: QT-RT x 5 weeks.
Capecitabine: 575 mg/m2 bid from Mon to Frid
Cisplatin 20 mg/m2 intravenously weekly.
Epirubicin 50 mg/m2 day 1
Cisplatin 60 mg/m2 day 1
Capecitabine 1000 mg/m2 bid for 14 d
every 3 weeks
Dikken et al. BMC Cancer 2011, 11:329
14. CONCLUSIONES
PACIENTES CANDIDATOS A QUIMIOTERAPIA
- RADIOTERAPIA CONCURRENTE
Cirugías insuficientes: D1
Ratio ganglionar: > 25%
Según clasificación de Lauren: Adenocarcinomas de
Tipo intestinal
Grupo Molecular: CIN.
¿ PORQUE ELIGIRÍA ADYUVANCIA COMO OPCION TERAPEUTICA ?
STATUS PERFORMANCE INADECUADO PARA NEOADYUVANCIA
PACIENTES CANDIDATOS A
QUIMIOTERAPIA SISTEMICA
Cirugías D2, R0