Boundary organizations like Land & Water Australia are inherently vulnerable due to tensions at the science-policy interface. LWA aimed to provide leadership in sustainable natural resource management through knowledge generation and informing debate. However, it struggled with the complex, long-term challenges of NRM issues that span disciplines and sectors. Lessons from LWA's demise include the need for boundary organizations to be agile, far-sighted brokers that can navigate the politics of science and policy.