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Waiting area at Chula Vista dentist Estrella Dental
Waiting area at Chula Vista dentist Estrella Dental
Signage on the wall near entrance at Chula Vista dentist Estrella Dental
Signage on the wall near entrance at Chula Vista dentist Estrella DentalEstrella Dental Implant & Cosmetic Center
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Logo on the entrance door at Chula Vista Estrella Dental
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Consultation room at Chula Vista dentist Estrella Dental
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Cleanliness comes first in the operatory at Chula Vista dentist Estrella DentalEstrella Dental Implant & Cosmetic Center
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Waiting area at Chula Vista dentist Estrella Dental
Waiting area at Chula Vista dentist Estrella Dental
Signage on the wall near entrance at Chula Vista dentist Estrella Dental
Signage on the wall near entrance at Chula Vista dentist Estrella DentalEstrella Dental Implant & Cosmetic Center
Signage on the wall near entrance at Chula Vista dentist Estrella DentalLogo on the entrance door at Chula Vista Estrella Dental
Logo on the entrance door at Chula Vista Estrella Dental
Consultation room at Chula Vista dentist Estrella Dental
Consultation room at Chula Vista dentist Estrella Dental
Comfy waiting area at Chula Vista dentist Estrella Dental
Comfy waiting area at Chula Vista dentist Estrella Dental
Cleanliness comes first in the operatory at Chula Vista dentist Estrella Dental
Cleanliness comes first in the operatory at Chula Vista dentist Estrella DentalEstrella Dental Implant & Cosmetic Center
Cleanliness comes first in the operatory at Chula Vista dentist Estrella DentalCleanliness and hygiene comes first at Chula Vista dentist Estrella dental
Cleanliness and hygiene comes first at Chula Vista dentist Estrella dentalEstrella Dental Implant & Cosmetic Center
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Chula Vista dentist Estrella Dental always ready to cope up with emergenciesEstrella Dental Implant & Cosmetic Center
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Advanced equipment at Chula Vista dentist Estrella DentaltalEstrella Dental Implant & Cosmetic Center
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Waiting area at Chula Vista dentist Estrella Dental
Treatment plan room at Chula Vista dentist Estrella Dental
Treatment plan room at Chula Vista dentist Estrella Dental
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3. Discuss the significance of dead space
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4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
How to Give Better Lectures: Some Tips for Doctors
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CDSCO and Phamacovigilance {Regulatory body in India}
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
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Olfactory Mucosa:
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Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
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Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
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From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
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