This document describes an activity where students will construct and analyze 3D cell models of different sizes to investigate how surface area to volume ratios impact cell size limitations. Students will measure the dimensions and volume of each model, calculate the total surface area, and determine the surface area to volume ratios. Analyzing these ratios may help explain why cells cannot continue to increase in size. The goal is for students to understand that larger volumes require more surface area for exchange of materials, and that surface area cannot increase indefinitely relative to volume.