1. Stage 0: Tis N o M o
Tis = carcinoma in situ
N o= no reginal lymph
node metastasis
M o= no distant metastasis
2. Stage 1: T1 N o M o
T 1 = tumor 2cm or less
in greatest dimension
3. Stage 2a:
To N1 Mo N1= metastasis
to ipsilateral
ax. Nodes
T1 N1 Mo mobile
T2 N o Mo T2= tumor>2cm
but <5cm in
greatest
dimention
4. Stage 2b:
T2 N1 Mo
T3 N o Mo T3= tumor size
> 5cm in
greatest
dimention
5. Stage 3a N2a =met to ipsilat axillary
node , fixed or matted
N2b= met to ipsilat int mammary
node in absence of ax. node
T o N2 M o
T1 N2 Mo
T2 N2 Mo
T3 N1 Mo
T3 N2 Mo
6. Stage 3b T4a= extension
to chest wall
T4b=
edema(Peaud’
Orange),
T4c= both T4a
& T4b
T4d=
inflammatory
carcinoma
T4 No Mo
T4 N1 Mo
T4 N2 Mo
T4 N2 Mo
7. Stage 3 c N3a= met to
ipsilat
infraclavicular LN
N3b= ipsilat
Internal mammary
& axillary LN
N3c= ipsilat
supraclavicular
LN
Any T
N3
Mo
8. Stage 4 : Any T any N + M1
M1= distant metastasis
9. C M F regimen
C – cyclophosphamide
M – methotrexate
F – 5 flurouracil
FAC regimen
F – 5 flurouracil
A – adriamycin(doxorubicin)
C – cyclophosphamide
AC regimen
A – adriamycin
C - cyclophosphamide
10. Trastuzumab : is a humanized murine
(Herceptin) monoclonal antibody raised
against erb B2, HER 2
surface receptor
Laptinib : a dual inhibitor of both
- EGFR
- HER 2
