This document outlines the staging system for breast cancer. Stage 0 is carcinoma in situ with no lymph node or distant metastasis. Stages 1-3 classify tumors based on size and extent of local and regional lymph node involvement. Stage 4 is any tumor with distant metastasis. Common chemotherapy regimens for breast cancer are listed, including CMF, FAC, and AC. Trastuzumab and Laptinib are targeted therapies for HER2 positive breast cancer.

1.  Stage 0: Tis N o M o
 Tis = carcinoma in situ
 N o= no reginal lymph
node metastasis

 M o= no distant metastasis

2.  Stage 1: T1 N o M o
 T 1 = tumor 2cm or less
in greatest dimension

3.  Stage 2a:
 To N1 Mo N1= metastasis
to ipsilateral
ax. Nodes
 T1 N1 Mo mobile
 T2 N o Mo T2= tumor>2cm
 but <5cm in
 greatest
 dimention

4.  Stage 2b:
 T2 N1 Mo
 T3 N o Mo T3= tumor size
> 5cm in
greatest
dimention

5. Stage 3a N2a =met to ipsilat axillary
node , fixed or matted
N2b= met to ipsilat int mammary
node in absence of ax. node
T o N2 M o
T1 N2 Mo
T2 N2 Mo
T3 N1 Mo
T3 N2 Mo

6. Stage 3b T4a= extension
to chest wall
T4b=
edema(Peaud’
Orange),
T4c= both T4a
& T4b
T4d=
inflammatory
carcinoma
T4 No Mo
T4 N1 Mo
T4 N2 Mo
T4 N2 Mo

7. Stage 3 c N3a= met to
ipsilat
infraclavicular LN
N3b= ipsilat
Internal mammary
& axillary LN
N3c= ipsilat
supraclavicular
LN
Any T
N3
Mo

8.  Stage 4 : Any T any N + M1
 M1= distant metastasis

9.  C M F regimen
 C – cyclophosphamide
 M – methotrexate
 F – 5 flurouracil
 FAC regimen
 F – 5 flurouracil
 A – adriamycin(doxorubicin)
 C – cyclophosphamide
 AC regimen
 A – adriamycin
 C - cyclophosphamide

10.  Trastuzumab : is a humanized murine
(Herceptin) monoclonal antibody raised
against erb B2, HER 2
surface receptor
 Laptinib : a dual inhibitor of both
- EGFR
- HER 2