The study analyzed weekly hospital admissions data in England from 2002-2008 to assess the short-term impact of smoke-free legislation introduced in July 2007. It found:
1) After adjusting for trends, seasonality, population size, temperature, and flu rates, emergency admissions for myocardial infarction (heart attacks) decreased by 2.4% (equivalent to 1,200 fewer admissions) following the legislation.
2) The reduction was greater in men and women aged 60 and over (3.1% for men, 3.8% for women) than in younger groups, though men under 60 also saw a significant decrease.
3) In total, the legislation was estimated to have prevented around 1,600
Tabaquismo factor de riesgo cardiovascular y disfuncion endotelial Ricardo Mora MD
Tabaquismo como factor de riesgo endotelial y disfuncion endotelial; Dr. Ricardo Mora Moreno R2C; IMSS UMAE T1; León, Guanajuato, Mexico; 09 de Noviembre del 2017
This document summarizes acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), including definitions, epidemiology, clinical presentation, predictors of poor outcome, mortality rates, and ventilator-based management strategies. It discusses the 1994 consensus definitions of ALI/ARDS, limitations of these definitions, updated recommendations, and stratification systems. It also describes mechanisms of ventilator-induced lung injury and the importance of limiting tidal volume and pressure to prevent further injury.
A 58-year-old woman was admitted with COVID-19 symptoms and developed cardiogenic and septic shock. An echocardiogram showed findings consistent with takotsubo cardiomyopathy - also known as stress cardiomyopathy - with left ventricular dysfunction. Her left ventricular function improved over the next few days, supporting the diagnosis of reversible acute stress cardiomyopathy secondary to COVID-19. This is the first reported case of takotsubo cardiomyopathy associated with COVID-19 in the United States.
The document discusses anticoagulation in COVID-19 patients. It notes that COVID-19 infection can cause a cytokine storm and increased risk of thrombosis. Studies have shown that 1/3 of hospitalized COVID-19 patients develop thrombotic complications. Several guidelines recommend prophylactic anticoagulation for hospitalized COVID-19 patients to reduce the risk of thromboembolism and lower mortality. Early initiation of prophylactic anticoagulation is associated with a 27% reduced risk of death within 30 days. The document discusses diagnostic tests for coagulopathy in COVID-19 patients and potential radiological findings of thromboembolic complications.
This document summarizes guidelines from the 2010 American Heart Association for treating cardiac arrest in special situations, including cardiac arrest associated with asthma. It provides details on the pathophysiology of severe asthma, including bronchoconstriction, airway inflammation, and mucous plugging. It recommends initial stabilization of patients with severe, life-threatening asthma with urgent administration of oxygen, bronchodilators, and steroids while closely monitoring for deterioration. Primary therapy focuses on oxygen supplementation and use of short-acting beta-agonists to provide rapid bronchodilation, with addition of ipratropium bromide and magnesium sulfate to further improve pulmonary function.
Cross talk between covid-19 and ischemic strokeafnaanqureshi1
This document discusses the relationship between COVID-19 and ischemic stroke. It notes that SARS-CoV-2 binds to ACE2 receptors, decreasing ACE2 activity and increasing angiotensin II levels, which can increase risks of hypertension, diabetes, and ischemic stroke. Studies have found elevated inflammatory cytokines and chemokines in COVID-19 patients that may damage the blood-brain barrier and increase stroke risk. There is also evidence that the neurological and pulmonary systems interact immunologically, so stroke may increase susceptibility to pulmonary infections like COVID-19. The document examines the involvement of the renin-angiotensin system and inflammatory responses in both conditions.
This document discusses the management of cardiovascular disease (CVD) during the COVID-19 pandemic. It notes that CVD patients have a higher risk of severe COVID-19 and complications. While the symptoms of CVD and COVID-19 can be similar, timely management of CVD emergencies is important. The document recommends a pharmacoinvasive strategy over primary PCI for STEMI patients when possible. It also provides guidance on managing other conditions like NSTEMI, heart failure and arrhythmias during the pandemic. Telemedicine is encouraged for stable patients to reduce hospital visits and risk of COVID-19 exposure.
Tabaquismo factor de riesgo cardiovascular y disfuncion endotelial Ricardo Mora MD
Tabaquismo como factor de riesgo endotelial y disfuncion endotelial; Dr. Ricardo Mora Moreno R2C; IMSS UMAE T1; León, Guanajuato, Mexico; 09 de Noviembre del 2017
This document summarizes acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), including definitions, epidemiology, clinical presentation, predictors of poor outcome, mortality rates, and ventilator-based management strategies. It discusses the 1994 consensus definitions of ALI/ARDS, limitations of these definitions, updated recommendations, and stratification systems. It also describes mechanisms of ventilator-induced lung injury and the importance of limiting tidal volume and pressure to prevent further injury.
A 58-year-old woman was admitted with COVID-19 symptoms and developed cardiogenic and septic shock. An echocardiogram showed findings consistent with takotsubo cardiomyopathy - also known as stress cardiomyopathy - with left ventricular dysfunction. Her left ventricular function improved over the next few days, supporting the diagnosis of reversible acute stress cardiomyopathy secondary to COVID-19. This is the first reported case of takotsubo cardiomyopathy associated with COVID-19 in the United States.
The document discusses anticoagulation in COVID-19 patients. It notes that COVID-19 infection can cause a cytokine storm and increased risk of thrombosis. Studies have shown that 1/3 of hospitalized COVID-19 patients develop thrombotic complications. Several guidelines recommend prophylactic anticoagulation for hospitalized COVID-19 patients to reduce the risk of thromboembolism and lower mortality. Early initiation of prophylactic anticoagulation is associated with a 27% reduced risk of death within 30 days. The document discusses diagnostic tests for coagulopathy in COVID-19 patients and potential radiological findings of thromboembolic complications.
This document summarizes guidelines from the 2010 American Heart Association for treating cardiac arrest in special situations, including cardiac arrest associated with asthma. It provides details on the pathophysiology of severe asthma, including bronchoconstriction, airway inflammation, and mucous plugging. It recommends initial stabilization of patients with severe, life-threatening asthma with urgent administration of oxygen, bronchodilators, and steroids while closely monitoring for deterioration. Primary therapy focuses on oxygen supplementation and use of short-acting beta-agonists to provide rapid bronchodilation, with addition of ipratropium bromide and magnesium sulfate to further improve pulmonary function.
Cross talk between covid-19 and ischemic strokeafnaanqureshi1
This document discusses the relationship between COVID-19 and ischemic stroke. It notes that SARS-CoV-2 binds to ACE2 receptors, decreasing ACE2 activity and increasing angiotensin II levels, which can increase risks of hypertension, diabetes, and ischemic stroke. Studies have found elevated inflammatory cytokines and chemokines in COVID-19 patients that may damage the blood-brain barrier and increase stroke risk. There is also evidence that the neurological and pulmonary systems interact immunologically, so stroke may increase susceptibility to pulmonary infections like COVID-19. The document examines the involvement of the renin-angiotensin system and inflammatory responses in both conditions.
This document discusses the management of cardiovascular disease (CVD) during the COVID-19 pandemic. It notes that CVD patients have a higher risk of severe COVID-19 and complications. While the symptoms of CVD and COVID-19 can be similar, timely management of CVD emergencies is important. The document recommends a pharmacoinvasive strategy over primary PCI for STEMI patients when possible. It also provides guidance on managing other conditions like NSTEMI, heart failure and arrhythmias during the pandemic. Telemedicine is encouraged for stable patients to reduce hospital visits and risk of COVID-19 exposure.
This document discusses burn injuries and their management. It covers the types and causes of burns, assessment of burn severity, fluid shifts that occur after burns, phases of burn injury including emergent, acute and rehabilitative, wound care including dressing changes and skin grafts, and nursing considerations such as monitoring for infection and maintaining nutrition and mobility. Burn injuries can lead to complications affecting many body systems and require careful ongoing assessment and treatment.
COVID-19 can cause cardiac injury through several mechanisms. It can cause acute heart failure, myocarditis, and exacerbate existing hypertension. Patients with COVID-19 should receive standard thromboprophylaxis and be monitored for potential pulmonary embolism. Drug interactions between antiviral treatments and other medications need to be considered, especially those that may prolong the QT interval. General advice for cardiac patients during the pandemic includes following social distancing measures and seeking medical care if new symptoms develop.
This document provides an overview of Acute Lung Injury (ALI), including:
1. The definition, history, epidemiology, and pathogenesis of ALI. It results from direct or indirect lung injury and involves endothelial and epithelial injury, neutrophil infiltration, and cytokine release.
2. The clinical presentation and stages of ALI from the acute/exudative stage with hyaline membrane formation to the proliferative/organizing stage and resolving/fibrotic stage.
3. Investigations for ALI including clinical criteria based on oxygenation and chest imaging findings typically showing bilateral infiltrates. Histopathology often reveals diffuse alveolar damage.
Copd systemic inflammation or systemic manifestationsWaheed Shouman
COPD is associated with systemic inflammation that can lead to several extra-pulmonary effects and comorbidities. Low-grade systemic inflammation in COPD patients is characterized by elevated levels of pro-inflammatory cytokines and acute phase proteins. This systemic inflammation may originate from pulmonary inflammation spilling over into the systemic circulation, or from other sources like smoking, hypoxia, or bacterial products during exacerbations. Systemic inflammation in COPD has been implicated in several systemic effects and comorbidities including weight loss, muscle dysfunction, cardiovascular diseases, osteoporosis, and depression. Treatments like pulmonary rehabilitation, smoking cessation, and some medications can help reduce systemic inflammation and its associated manifestations in COPD.
Addison’s Disease (AD) or primary adrenal insuffi ciency has been thought a rare disease for a long time, but recent epidemiological studies have reported a rising prevalence in developed countries. Among the causes of apparently idiopathic forms, autoimmunity plays a relevant role. This review will be focused on several aspects of autoimmune AD, which may manifest either as an isolated disorder or associated with other autoimmune diseases among the autoimmune polyglandular syndromes. HLA plays a key role in determining. T cell responses to antigens, and various HLA alleles have been shown to be associated with many T cell-mediated autoimmune
disorders, but the mechanism by which the adrenal cortex is destroyed in AD is still discussed. Cytotoxic T lymphocytes are thought. to be the most important effector cells in mediating the autoimmune tissue destruction, because Adrenal Cortex Autoantibodies (ACA) and/or autoantibodies against 21 idroxylase (21-OHAb) do not seem to be directly involved in the pathogenesis, being considered only good marker of the disease both in clinical and in preclinical stage. In fact, subclinical autoimmune AD can evolve trough 5 functional
stages from stage 0 (only presence of autoantibodies) to stage 4 (clinically overt disease). All the fi ve stages are characterized by the presence of these antibodies but only when they are present at high titre in subclinical stages are associated with the progression towards clinically overt autoimmune AD, whereas a spontaneous remission of subclinical adrenal dysfunction with their disappearance may occur when they are present at low titres. Treatment of AD is based on the use of hydrocortisone or cortisone for symptomatic patients; fl udrocortisone should be used as substitute for mineral-corticosteroids. In some cases, an early replacement therapy has been shown to be helpful to interrupt the progression towards the clinical stage with disappearance of these autoantibodies and recovery of adrenal
function. In addition, a life-threatening adrenal crisis in patients with chronic adrenal insuffi ciency under established replacement therapy. may occur. Clinical medicine must pay attention to these situations because an untreated Addisonian crisis is a medical emergency that requires hospitalization, and if not caught early can be fatal.
Risk factors of Acute Coronary Syndrome at Prince Ali Bin Alhussein hospitalMinistry of Health
Objective:The aim of this survey to identify the relationship between ACS and its risk factors and the association between the risks factors themselves. Method: A retrospective study depends on the registered files of the admitted patients to Prince Ali Bin Alhussein hospital with ACS since April 2013 till October of 2013 included 174 patients. Result:The above mentioned data and results show a strong relationship between ACS and the mentioned risk factors. Conclusion: There is a strong relationship between risks factors themselves as D.M and hypertension, and between hypertension with the sex and smoking.There's an association between D.M and the patient's gender
Thermal Imaging for the Diagnosis of Early Vascular Dysfunctions: A Case Reportasclepiuspdfs
Diseases of blood vessels (referred in this article as vascular dysfunction) cause more morbidity and mortality, than combined impact of any other major non-communicable disease including cancer. We strongly feel that the development of a therapy system based on the management of disease of the vessel than management of the risk factors will yield better results and provide greater opportunity for individualized therapy. Detection of early vascular changes before clinical manifestations of endothelial dysfunction, hardening of the arteries, increased intima-media thickness, is of great importance for early identification of individuals with increased risk of accelerated atherosclerosis.
This document provides information on burn injuries and their management. It discusses the causes and types of burns, assessment of burn depth and severity, fluid shifts that occur after burns, and the emergent, acute, and rehabilitative phases of burn injury and treatment. Key aspects of burn management include wound care, infection prevention, fluid resuscitation based on burn size, nutritional support, and rehabilitation of mobility and body image.
A 67-year-old woman presented with respiratory symptoms and was diagnosed with COVID-19. One week later, she presented with worsening symptoms and was found to have a large hemorrhagic pericardial effusion causing cardiac tamponade. She underwent pericardiocentesis, draining 800ml of fluid. After the procedure, she developed signs of takotsubo cardiomyopathy. The case report discusses the rare presentation of cardiac tamponade secondary to COVID-19 infection and the subsequent development of takotsubo cardiomyopathy.
This study compared the 7-year risk of heart attack in people with and without type 2 diabetes. It found:
1) The risk of heart attack over 7 years was much higher in people with prior heart attack (18.8% without diabetes, 45% with diabetes) compared to those without (3.5% without diabetes, 20.2% with diabetes).
2) People with diabetes but no prior heart attack had a similar risk of death from heart disease as people without diabetes but with a prior heart attack.
3) These findings suggest that people with diabetes should be treated as aggressively for cardiovascular risk factors as nondiabetic people with established heart disease.
all details explain about corona virus
corona virus slide
covid19 pandemic
epidemiology
pathogenesis
oral pathology
medicine
history
introduction
outbreak
prevent
drugs
test
steps taken by govt
This document discusses comorbidities and systemic effects of chronic obstructive pulmonary disease (COPD). It begins by defining COPD and comorbidity, noting that COPD is considered a multicomponent disease. Smoking is identified as the main risk factor for COPD and is linked to several other diseases. The document then reviews the prevalence of various comorbidities in COPD patients, including cardiovascular, bone, and smoking-related conditions. It also discusses muscle wasting specifically, including its prevalence in COPD patients and factors involved in its pathogenesis.
This document discusses the high burden of cardiovascular disease (CVD) in India and the link between air pollution and increased risk of CVD. It provides the following key points:
1. CVD is the leading cause of death in India, with rates higher than global averages. Major CVDs include IHD, cerebrovascular disease, and hypertension.
2. Risk factors for CVD like hypertension and diabetes are rising dramatically in India and projected to affect hundreds of millions by 2030.
3. Existing evidence suggests air pollution likely increases the risk of CVD and its risk factors through mechanisms like endothelial dysfunction, inflammation, and increased blood pressure.
4. Research aims to better characterize the associations between long-term air
This document analyzes the impact of sepsis on conditions targeted by the Hospital Readmissions Reduction Program (HRRP). It finds that sepsis increases risks for several HRRP conditions like acute myocardial infarction (AMI), congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and pneumonia. Patients with sepsis and AMI have high mortality (28%) and case mix index (3.4). Sepsis combined with COPD or pneumonia poses the greatest risks, including higher odds of other HRRP conditions. The document recommends focus on less severe sepsis cases to prevent progression.
Evaluation of Cardiac Complications in Pateint Undergoing COVID 19 Treatment:...DrHeena tiwari
This study evaluated cardiac complications in 45 COVID-19 patients admitted to the intensive care unit. Electrocardiography and Holter monitoring found various arrhythmias in patients, with atrial fibrillation, premature ventricular contraction, and tachycardia being most common. The mortality rate of arrhythmias in COVID-19 patients was 17.77%. Although arrhythmias are not very frequent in COVID-19, they can be fatal and have a high mortality rate. Early detection of arrhythmias can help prevent deaths.
Chronic obstructive pulmonary disease (COPD) is defined by several medical organizations and involves persistent airflow limitation that is usually progressive. Key indicators for considering COPD include dyspnea, chronic cough, sputum production, exposure to risk factors like smoking, and family history. COPD is assessed based on symptoms, degree of airflow limitation via spirometry, risk of exacerbations, and comorbidities. Exacerbations, which involve worsening of respiratory symptoms, are usually caused by infections and can be mild, moderate, or severe requiring hospitalization. COPD is a major cause of death and disability worldwide.
Pulmonary Complications of Sickle Cell Disease. pptxSarfraz Saleemi
This document summarizes pulmonary complications of sickle cell disease (SCD), including acute chest syndrome (ACS) and pulmonary hypertension (PH). It notes that ACS and PH are the most serious complications, with high morbidity and mortality. The document reviews the definition, risk factors, pathophysiology, diagnosis, and management of ACS. It also discusses the prevalence of PH in SCD populations worldwide and in Saudi Arabia, ranging from 20-38%. The pathophysiology of SCD-related PH involves chronic hypoxemia, endothelial dysfunction, and elevated pulmonary pressures from infarcts and vaso-occlusion. Independent risk factors for PH development in SCD include low hemoglobin, cardiovascular or renal disease, and elevated
This document discusses the cardiovascular manifestations and effects of COVID-19. Some key points:
- Cardiovascular disease is a common comorbidity in patients with COVID-19, SARS, and MERS. Myocardial injury is independently associated with high mortality in COVID-19 patients.
- SARS-CoV-2 binds to ACE2 receptors, which are highly expressed in heart, blood vessels and other organs. This disrupts the balance between protective and deleterious RAAS pathways.
- COVID-19 can cause direct damage to heart through ACE2 downregulation and indirect damage from cytokine release/coagulopathy. This leads to complications like myocarditis, heart failure, arrhythmias and
1. Acute respiratory distress syndrome (ARDS) is characterized by acute onset hypoxemia, decreased lung compliance, and bilateral pulmonary infiltrates without evidence of cardiac failure.
2. ARDS is caused by direct lung injury from factors like pneumonia, aspiration, shock, sepsis, or trauma which lead to increased vascular permeability and disruption of the alveolar-capillary barrier.
3. Treatment involves identifying and treating the underlying cause, supportive care including mechanical ventilation with low tidal volumes, and preventing complications.
This document discusses burn injuries and their management. It covers the types and causes of burns, assessment of burn severity, fluid shifts that occur after burns, phases of burn injury including emergent, acute and rehabilitative, wound care including dressing changes and skin grafts, and nursing considerations such as monitoring for infection and maintaining nutrition and mobility. Burn injuries can lead to complications affecting many body systems and require careful ongoing assessment and treatment.
COVID-19 can cause cardiac injury through several mechanisms. It can cause acute heart failure, myocarditis, and exacerbate existing hypertension. Patients with COVID-19 should receive standard thromboprophylaxis and be monitored for potential pulmonary embolism. Drug interactions between antiviral treatments and other medications need to be considered, especially those that may prolong the QT interval. General advice for cardiac patients during the pandemic includes following social distancing measures and seeking medical care if new symptoms develop.
This document provides an overview of Acute Lung Injury (ALI), including:
1. The definition, history, epidemiology, and pathogenesis of ALI. It results from direct or indirect lung injury and involves endothelial and epithelial injury, neutrophil infiltration, and cytokine release.
2. The clinical presentation and stages of ALI from the acute/exudative stage with hyaline membrane formation to the proliferative/organizing stage and resolving/fibrotic stage.
3. Investigations for ALI including clinical criteria based on oxygenation and chest imaging findings typically showing bilateral infiltrates. Histopathology often reveals diffuse alveolar damage.
Copd systemic inflammation or systemic manifestationsWaheed Shouman
COPD is associated with systemic inflammation that can lead to several extra-pulmonary effects and comorbidities. Low-grade systemic inflammation in COPD patients is characterized by elevated levels of pro-inflammatory cytokines and acute phase proteins. This systemic inflammation may originate from pulmonary inflammation spilling over into the systemic circulation, or from other sources like smoking, hypoxia, or bacterial products during exacerbations. Systemic inflammation in COPD has been implicated in several systemic effects and comorbidities including weight loss, muscle dysfunction, cardiovascular diseases, osteoporosis, and depression. Treatments like pulmonary rehabilitation, smoking cessation, and some medications can help reduce systemic inflammation and its associated manifestations in COPD.
Addison’s Disease (AD) or primary adrenal insuffi ciency has been thought a rare disease for a long time, but recent epidemiological studies have reported a rising prevalence in developed countries. Among the causes of apparently idiopathic forms, autoimmunity plays a relevant role. This review will be focused on several aspects of autoimmune AD, which may manifest either as an isolated disorder or associated with other autoimmune diseases among the autoimmune polyglandular syndromes. HLA plays a key role in determining. T cell responses to antigens, and various HLA alleles have been shown to be associated with many T cell-mediated autoimmune
disorders, but the mechanism by which the adrenal cortex is destroyed in AD is still discussed. Cytotoxic T lymphocytes are thought. to be the most important effector cells in mediating the autoimmune tissue destruction, because Adrenal Cortex Autoantibodies (ACA) and/or autoantibodies against 21 idroxylase (21-OHAb) do not seem to be directly involved in the pathogenesis, being considered only good marker of the disease both in clinical and in preclinical stage. In fact, subclinical autoimmune AD can evolve trough 5 functional
stages from stage 0 (only presence of autoantibodies) to stage 4 (clinically overt disease). All the fi ve stages are characterized by the presence of these antibodies but only when they are present at high titre in subclinical stages are associated with the progression towards clinically overt autoimmune AD, whereas a spontaneous remission of subclinical adrenal dysfunction with their disappearance may occur when they are present at low titres. Treatment of AD is based on the use of hydrocortisone or cortisone for symptomatic patients; fl udrocortisone should be used as substitute for mineral-corticosteroids. In some cases, an early replacement therapy has been shown to be helpful to interrupt the progression towards the clinical stage with disappearance of these autoantibodies and recovery of adrenal
function. In addition, a life-threatening adrenal crisis in patients with chronic adrenal insuffi ciency under established replacement therapy. may occur. Clinical medicine must pay attention to these situations because an untreated Addisonian crisis is a medical emergency that requires hospitalization, and if not caught early can be fatal.
Risk factors of Acute Coronary Syndrome at Prince Ali Bin Alhussein hospitalMinistry of Health
Objective:The aim of this survey to identify the relationship between ACS and its risk factors and the association between the risks factors themselves. Method: A retrospective study depends on the registered files of the admitted patients to Prince Ali Bin Alhussein hospital with ACS since April 2013 till October of 2013 included 174 patients. Result:The above mentioned data and results show a strong relationship between ACS and the mentioned risk factors. Conclusion: There is a strong relationship between risks factors themselves as D.M and hypertension, and between hypertension with the sex and smoking.There's an association between D.M and the patient's gender
Thermal Imaging for the Diagnosis of Early Vascular Dysfunctions: A Case Reportasclepiuspdfs
Diseases of blood vessels (referred in this article as vascular dysfunction) cause more morbidity and mortality, than combined impact of any other major non-communicable disease including cancer. We strongly feel that the development of a therapy system based on the management of disease of the vessel than management of the risk factors will yield better results and provide greater opportunity for individualized therapy. Detection of early vascular changes before clinical manifestations of endothelial dysfunction, hardening of the arteries, increased intima-media thickness, is of great importance for early identification of individuals with increased risk of accelerated atherosclerosis.
This document provides information on burn injuries and their management. It discusses the causes and types of burns, assessment of burn depth and severity, fluid shifts that occur after burns, and the emergent, acute, and rehabilitative phases of burn injury and treatment. Key aspects of burn management include wound care, infection prevention, fluid resuscitation based on burn size, nutritional support, and rehabilitation of mobility and body image.
A 67-year-old woman presented with respiratory symptoms and was diagnosed with COVID-19. One week later, she presented with worsening symptoms and was found to have a large hemorrhagic pericardial effusion causing cardiac tamponade. She underwent pericardiocentesis, draining 800ml of fluid. After the procedure, she developed signs of takotsubo cardiomyopathy. The case report discusses the rare presentation of cardiac tamponade secondary to COVID-19 infection and the subsequent development of takotsubo cardiomyopathy.
This study compared the 7-year risk of heart attack in people with and without type 2 diabetes. It found:
1) The risk of heart attack over 7 years was much higher in people with prior heart attack (18.8% without diabetes, 45% with diabetes) compared to those without (3.5% without diabetes, 20.2% with diabetes).
2) People with diabetes but no prior heart attack had a similar risk of death from heart disease as people without diabetes but with a prior heart attack.
3) These findings suggest that people with diabetes should be treated as aggressively for cardiovascular risk factors as nondiabetic people with established heart disease.
all details explain about corona virus
corona virus slide
covid19 pandemic
epidemiology
pathogenesis
oral pathology
medicine
history
introduction
outbreak
prevent
drugs
test
steps taken by govt
This document discusses comorbidities and systemic effects of chronic obstructive pulmonary disease (COPD). It begins by defining COPD and comorbidity, noting that COPD is considered a multicomponent disease. Smoking is identified as the main risk factor for COPD and is linked to several other diseases. The document then reviews the prevalence of various comorbidities in COPD patients, including cardiovascular, bone, and smoking-related conditions. It also discusses muscle wasting specifically, including its prevalence in COPD patients and factors involved in its pathogenesis.
This document discusses the high burden of cardiovascular disease (CVD) in India and the link between air pollution and increased risk of CVD. It provides the following key points:
1. CVD is the leading cause of death in India, with rates higher than global averages. Major CVDs include IHD, cerebrovascular disease, and hypertension.
2. Risk factors for CVD like hypertension and diabetes are rising dramatically in India and projected to affect hundreds of millions by 2030.
3. Existing evidence suggests air pollution likely increases the risk of CVD and its risk factors through mechanisms like endothelial dysfunction, inflammation, and increased blood pressure.
4. Research aims to better characterize the associations between long-term air
This document analyzes the impact of sepsis on conditions targeted by the Hospital Readmissions Reduction Program (HRRP). It finds that sepsis increases risks for several HRRP conditions like acute myocardial infarction (AMI), congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and pneumonia. Patients with sepsis and AMI have high mortality (28%) and case mix index (3.4). Sepsis combined with COPD or pneumonia poses the greatest risks, including higher odds of other HRRP conditions. The document recommends focus on less severe sepsis cases to prevent progression.
Evaluation of Cardiac Complications in Pateint Undergoing COVID 19 Treatment:...DrHeena tiwari
This study evaluated cardiac complications in 45 COVID-19 patients admitted to the intensive care unit. Electrocardiography and Holter monitoring found various arrhythmias in patients, with atrial fibrillation, premature ventricular contraction, and tachycardia being most common. The mortality rate of arrhythmias in COVID-19 patients was 17.77%. Although arrhythmias are not very frequent in COVID-19, they can be fatal and have a high mortality rate. Early detection of arrhythmias can help prevent deaths.
Chronic obstructive pulmonary disease (COPD) is defined by several medical organizations and involves persistent airflow limitation that is usually progressive. Key indicators for considering COPD include dyspnea, chronic cough, sputum production, exposure to risk factors like smoking, and family history. COPD is assessed based on symptoms, degree of airflow limitation via spirometry, risk of exacerbations, and comorbidities. Exacerbations, which involve worsening of respiratory symptoms, are usually caused by infections and can be mild, moderate, or severe requiring hospitalization. COPD is a major cause of death and disability worldwide.
Pulmonary Complications of Sickle Cell Disease. pptxSarfraz Saleemi
This document summarizes pulmonary complications of sickle cell disease (SCD), including acute chest syndrome (ACS) and pulmonary hypertension (PH). It notes that ACS and PH are the most serious complications, with high morbidity and mortality. The document reviews the definition, risk factors, pathophysiology, diagnosis, and management of ACS. It also discusses the prevalence of PH in SCD populations worldwide and in Saudi Arabia, ranging from 20-38%. The pathophysiology of SCD-related PH involves chronic hypoxemia, endothelial dysfunction, and elevated pulmonary pressures from infarcts and vaso-occlusion. Independent risk factors for PH development in SCD include low hemoglobin, cardiovascular or renal disease, and elevated
This document discusses the cardiovascular manifestations and effects of COVID-19. Some key points:
- Cardiovascular disease is a common comorbidity in patients with COVID-19, SARS, and MERS. Myocardial injury is independently associated with high mortality in COVID-19 patients.
- SARS-CoV-2 binds to ACE2 receptors, which are highly expressed in heart, blood vessels and other organs. This disrupts the balance between protective and deleterious RAAS pathways.
- COVID-19 can cause direct damage to heart through ACE2 downregulation and indirect damage from cytokine release/coagulopathy. This leads to complications like myocarditis, heart failure, arrhythmias and
1. Acute respiratory distress syndrome (ARDS) is characterized by acute onset hypoxemia, decreased lung compliance, and bilateral pulmonary infiltrates without evidence of cardiac failure.
2. ARDS is caused by direct lung injury from factors like pneumonia, aspiration, shock, sepsis, or trauma which lead to increased vascular permeability and disruption of the alveolar-capillary barrier.
3. Treatment involves identifying and treating the underlying cause, supportive care including mechanical ventilation with low tidal volumes, and preventing complications.
This document contains 6 abstracts from epidemiology conferences that discuss various topics related to climate change and environmental health. The abstracts report on research related to heat-related mortality and heat warning systems in the US, mortality related to temperature extremes, the impact of diurnal temperature range on cardiovascular hospital admissions, defining temperature thresholds for heat warning systems in France, the effects of heatwaves on health outcomes in Adelaide, Australia, and projecting temperature-related mortality impacts in New York City under climate change.
Health in Southampton: Assessing smoking and air pollution variation within t...Nick Kirrage
This document provides an overview of smoking and air pollution in Southampton. It discusses the literature on the social and spatial epidemiology of smoking, noting higher rates among lower socioeconomic groups and certain regions. The document then reviews air pollution literature, referencing a 1952 smog event in London that caused thousands of deaths. The document aims to examine smoking and air pollution rates and their relationships to inequalities within Southampton.
The American Heart Association has updated its scientific statement on the link between air pollution and cardiovascular disease. The evidence shows that exposure to fine particulate matter (PM2.5) can trigger heart attacks, strokes and death, especially in susceptible individuals such as the elderly and those with heart disease. Long-term exposure to elevated PM2.5 levels increases cardiovascular risk and reduces life expectancy. While reducing traditional risk factors is important, people should also limit their exposure to air pollution when possible and support policies to decrease particulate matter levels.
The document discusses the relationship between air pollution and heart disease. It notes that air pollution contributes to both acute and long-term cardiovascular issues like heart attacks, strokes, heart failure and arrhythmias. The main pollutants of concern are particulate matter and gases like ozone, nitrogen dioxide and volatile organic compounds which are emitted through combustion. Long-term exposure is associated with increased risks of coronary artery disease, heart failure, and cerebrovascular disease through mechanisms like oxidative stress, inflammation and endothelial dysfunction.
This document discusses the relationship between COVID-19 and diabetes based on clinical observations from China, Italy, and the United States. Emerging evidence shows that diabetes is a common comorbidity in patients with severe COVID-19 and may increase the risk of mortality. The document then reviews the pathogenesis and immune response to SARS-CoV-2 before discussing potential mechanisms by which diabetes could increase susceptibility to infection and severe disease. It concludes by highlighting areas for further investigation and management considerations for clinicians.
This document discusses a protocol for a systematic review that aims to synthesize evidence on the relative risk of mortality in type 2 diabetes mellitus (T2DM). It provides background on the prevalence of T2DM and discusses inconsistencies in reported mortality rates. The systematic review will explore all-cause mortality risk in T2DM expressed as hazard ratios, and examine subgroups based on age, gender, socioeconomic factors and causes of death. The review expects to pool data from large cohort studies to accurately summarize the actual mortality risk in T2DM with limited bias and help direct future research.
A national study on long-term exposure to air pollution to human health and correlation to COVID-19 mortality - pollution kills and every 1ug/m3 PM 2.5 increases the death rate from COVID by 15%.
Cardiogenic shock is defined as a state of acute circulatory failure due to impaired cardiac function where there is inadequate tissue oxygenation. The definition has evolved over time to be less focused on specific hemodynamic parameters and more on clinical signs of hypoperfusion. It can be classified clinically or based on hemodynamics. While acute coronary syndrome is a leading cause, the contribution of other causes is increasing. Mortality remains high though some studies show improvement. Recognition of evolving definitions and classifications aims to improve management of this complex syndrome.
1) The study investigated the relationship between body temperature (Tb) abnormalities and disease severity and outcomes in 624 patients with severe sepsis.
2) Patients with hypothermia (Tb ≤36.5°C) had significantly higher organ failure scores, illness severity scores, rates of disseminated intravascular coagulation, and 28-day and hospital mortality compared to patients without hypothermia (Tb >36.5°C).
3) Hypothermia was found to be an independent predictor of increased 28-day mortality in patients with severe sepsis, irrespective of whether they had septic shock.
The study examined the association between proton pump inhibitor (PPI) prescriptions and the risk of community acquired pneumonia using data from the UK's Clinical Practice Research Datalink. Three analytical methods were used: a cohort study comparing PPI users to non-users adjusted for confounders, a self-controlled case series comparing periods before and after PPI use, and a prior event rate ratio analysis comparing periods before and after the first PPI prescription. All three methods suggested that confounding factors present before PPI use, rather than PPI use itself, best explained the increased rate of community acquired pneumonia seen in PPI patients. The association between PPI use and pneumonia risk observed in previous studies is likely entirely due to
The study examined the association between proton pump inhibitor (PPI) prescriptions and the risk of community acquired pneumonia using data from the UK's Clinical Practice Research Datalink. Three methods were used: a cohort study comparing PPI users to non-users adjusted for confounders, a self-controlled case series comparing periods before and after PPI use, and examining event rates before and after the first PPI prescription. All methods suggested the observed association between PPI use and pneumonia was likely due entirely to underlying confounding factors present before PPI use, rather than being caused by PPI use itself.
This study examined the acute effects of smoking electronic cigarettes (EC) and tobacco cigarettes (TC) on sympathetic nerve activity and blood pressure in healthy male smokers. 12 male smokers underwent measurements of muscle sympathetic nerve activity, skin sympathetic nerve activity, heart rate, and blood pressure at baseline and after smoking either 2 TC cigarettes, an EC, or sham smoking. Both TC and EC smoking significantly increased blood pressure and heart rate compared to baseline. Both also significantly decreased muscle sympathetic nerve activity and increased skin sympathetic nerve activity, with similar effects between TC and EC smoking. The responses to smoking were greater than those from sham smoking. The results suggest that the acute effects of EC smoking on the autonomic nervous system and hemodynamics are similar to
11,000 premature deaths were avoided in Europe due to reduced air pollution levels resulting from decreased coal and oil consumption during coronavirus lockdowns. Nitrogen dioxide pollution levels decreased 40% on average and particulate matter levels fell 10%, leading to avoided health impacts such as fewer asthma cases and work absences. However, air pollution still contributes to worse pandemic outcomes by increasing vulnerability to the virus and exacerbating existing health conditions. The analysis demonstrates the significant public health benefits of transitioning to clean energy.
This document summarizes several studies investigating the relationship between smoking and venous thromboembolism (VTE) risk. The studies found:
1) Current smoking was associated with a higher risk of VTE compared to never smokers, with a positive dose-response relationship. Former smokers had the same risk as never smokers.
2) Heavier smokers (>20 pack-years) had higher risks of total and provoked VTE compared to never smokers. The risk of provoked VTE increased with more pack-years of smoking.
3) The modestly increased risks of VTE in current or former women smokers were attenuated after adjusting for smoking-related diseases and decreased physical activity, suggesting an indirect relationship between smoking
Teens and young adults are increasingly using electronic cigarettes, but little is known about the long-term cardiopulmonary health effects of these nicotine-delivery devices.
During this webinar, Jason Gardner, PhD, presents his latest findings using a mouse model of chronic, inhaled nicotine exposure. Post-exposure to nicotine caused mice to develop pulmonary hypertension (PH) and right ventricular (RV) remodeling, a phenomenon that is prevented using an angiotensin II type I receptor (AT1) blocker, losartan. Dr. Gardner discusses the details of this work and how the renin-angiotensin system plays a key role in PH and RV remodeling. In addition, he expands upon the current research with new, unpublished findings.
For more information or to watch the webinar, visit https://bit.ly/3guetlr
White Paper- A non-invasive blood test for diagnosing lung cancerDusty Majumdar, PhD
Lung cancer is the leading cause of cancer death worldwide. While low-dose CT screening can reduce lung cancer mortality, it has low specificity resulting in many false positives and unnecessary invasive follow-ups that increase costs. A blood-based biomarker test could potentially improve the specificity of CT screening by reducing false positives. Exact Sciences and MD Anderson are collaborating to develop a multi-marker blood test to complement CT screening for lung cancer, with the goal of a test that matches or exceeds CT's performance to make screening more effective and cost-efficient.
The document discusses the role of oral mucolytics in the prevention of lower respiratory tract infections (LRTIs) in patients with chronic obstructive pulmonary disease (COPD). It summarizes the findings of clinical trials that show mucolytics reduce exacerbations in COPD patients not treated with inhaled corticosteroids. However, the largest trial (BRONCUS) found no difference in exacerbation rates between N-acetylcysteine and placebo in COPD patients, though a subgroup analysis found fewer exacerbations in patients not on inhaled corticosteroids with N-acetylcysteine. Given most COPD patients are now treated with inhaled corticosteroids, the role of mucolytics in
MICAS is a brief questionnaire which clients can fill out. As a result, the fidelity of their coach/HCP in the delivery of motivational interviewing will be reliably measured, within the framework of physical activity stimulation.
Addiction and Motivation; what works?
Presentation at the 2012 Europad conference in Barcelona.
Three main points:
- Evidence base for Motivational Interviewing
- Practitioner competency
- Implementation issues
1) Motivational interviewing (MI) arose from research on therapist empathy that found empathy strongly predicted client drinking outcomes.
2) MI was then developed as a clinical method focused on differentially responding to client speech to evoke and strengthen their own motivations for change.
3) Research found that MI alone or added to other treatments significantly increased client abstinence and retention in treatment programs for substance use issues. However, outcomes have varied across populations and studies.
Motivational Interviewing is an approach that uses a guiding style to engage patients and elicit their own motivations for behavior change. It has been shown to be effective across healthcare settings. Key aspects include practicing an engaging rather than directing style, developing strategies to understand patient motivations, and refining listening skills to encourage change talk. The approach aims to promote patient autonomy and work with their strengths to find solutions, rather than just focusing on problems.
This document introduces the inaugural issue of the journal Motivational Interviewing: Training, Research, Implementation, Practice. It provides a brief history of publications related to motivational interviewing, from the original Motivational Interviewing Newsletter for Trainers to the current journal. It explains that the journal aims to provide an outlet for the worldwide MI community and allow communication among members. The introduction welcomes readers and contributors to share in the open and creative spirit that characterizes both MI and its community.
This document discusses supporting smoking cessation in healthcare. It explores gaps in understanding tobacco addiction and challenges in managing smoking cessation. The authors conducted a literature review and expert assessment to formulate recommendations. They found that smoking is not widely viewed as an addiction and few smokers seek help quitting from healthcare professionals. While professionals recognize advising patients to quit, barriers exist to doing so. Overall, more must be done to convince professionals that smoking is an addiction requiring treatment like other addictions.
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share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
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Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
1. RESEARCH
Short term impact of smoke-free legislation in England:
retrospective analysis of hospital admissions for myocardial
infarction
Michelle Sims, research officer,1,2 Roy Maxwell, senior analyst ,3 Linda Bauld, professor of social policy,2,4 Anna
Gilmore, clinical reader in public health,1,2 clinical senior lecturer5
1
School for Health, University of ABSTRACT smoker as a proxy for exposure underestimated
Bath, Bath BA2 7AY Objective To measure the short term impact on hospital exposure.5 Recent evidence, based on more accurate
2
UK Centre for Tobacco Control admissions for myocardial infarction of the introduction biological markers of exposure, suggests the risk could
Studies, University of Bath, Bath
3
South West Public Health
of smoke-free legislation in England on 1 July 2007. be increased by as much as 60%, similar to that
Observatory, Bristol BS8 2RA Design An interrupted time series design with routinely observed in light active smokers.8 Although this risk
4
Department of Social and Policy collected hospital episode statistics data. Analysis of might seem disproportionate, it is consistent with sub-
Sciences, University of Bath, Bath admissions from July 2002 to September 2008 (providing stantial epidemiological and laboratory evidence that
5
London School of Hygiene and five years’ data from before the legislation and 15 months’ the risk of coronary heart disease increases rapidly at
Tropical Medicine, London
WC1E 7HT data from after) using segmented Poisson regression. low levels of exposure to tobacco smoke.9 10 Even small
Correspondence to: A Gilmore, Setting England. exposures have been shown to rapidly increase platelet
School for Health, University of Population All patients aged 18 or older living in England aggregation and alter endothelial function (with such
Bath, Bath BA2 7AY
a.gilmore@bath.ac.uk with an emergency admission coded with a primary changes observed within 30 minutes of exposure) and
diagnosis of myocardial infarction. cause other arterial and haemodynamic changes that
Cite this as: BMJ 2010;340:c2161 Main outcome measures Weekly number of completed can increase the risk of coronary heart disease and trig-
doi:10.1136/bmj.c2161
hospital admissions. ger acute coronary events.7 9 11-13 Measures that reduce
Results After adjustment for secular and seasonal trends exposure to secondhand smoke, such as smoke-free
and variation in population size, there was a small but legislation, are therefore likely to reduce the incidence
significant reduction in the number of emergency of acute coronary events, including myocardial infarc-
admissions for myocardial infarction after the tion, with almost immediate effect.12
implementation of smoke-free legislation (−2.4%, 95% Smoke-free legislation has now been introduced in
confidence interval −4.06% to −0.66%, P=0.007). This several jurisdictions, and a growing body of evidence
equates to 1200 fewer emergency admissions for links the introduction of this legislation with a reduc-
myocardial infarction (1600 including readmissions) in tion in hospital admissions for myocardial infarction
the first year after legislation. The reduction in admissions and other acute coronary events.14-17 The largest
was significant in men (3.1%, P=0.001) and women impacts have been reported in smaller studies in the
(3.8%, P=0.007) aged 60 and over, and men (3.5%, United States,18-20 with reported reductions in the
P<0.01) but not women (2.5% P=0.38) aged under 60. range of 27-40%, while larger studies have reported
Conclusion This study adds to a growing body of evidence more modest reductions: 8% in the state of New
that smoke-free legislation leads to reductions in York,21 13% in four Italian regions,22 and 17% in
myocardial infarctions. It builds on previous work by Scotland.23 Only two studies in New Zealand24 and
showing that such declines are observed even when Piedmont, Italy,25 found no reduction in overall admis-
underlying reductions in admissions and potential sions for myocardial infarction, although the Italian
confounders are controlled for. The considerably smaller study found an 11% decline in those aged under 60.
decline in admissions observed in England compared There is some uncertainty around the extent to
with many other jurisdictions probably reflects aspects of which some of these studies have effectively accounted
the study design and the relatively low levels of exposure for other factors that might influence patterns of admis-
to secondhand smoke in England before the legislation. sions for myocardial infarction. Firstly, admissions for
coronary heart disease have been declining across
INTRODUCTION Europe,26-30 the US,31 and Canada,32 and failure to
Numerous studies, including six meta-analyses,1-6 have account for this might lead to an overestimation of
shown that passive smoking increases the risk of cor- impacts. Secondly, other factors such as season, flu,
onary heart disease.7 Early studies estimated the and temperature have all been shown to influence the
increased risk at about 30%, but use of marriage to a incidence of myocardial infarction with, for example,
BMJ | ONLINE FIRST | bmj.com page 1 of 8
2. RESEARCH
peak admission rates in winter, in spring, and over the for myocardial infarction after the legislation, was
Christmas break, and seen in association with high flu assessed by including a binary predictor variable in
rates and low temperatures.33-36 Most studies the model with a value of 1 assigned to myocardial
accounted for seasonal differences when estimating infarction events occurring from week 27 of that year
impacts of smoke-free legislation on coronary heart (that is, from 2 July 2007 onwards) and 0 before.
disease, either by comparing the same months in a An initial exploration of the form of the long term
before-after study design20 23 25 37 38 or including a pre- time trend suggested that a linear assumption was
dictor for time of year in a regression model.18 21 24 appropriate, so we used a linear predictor for time to
Few studies, however, fully accounted for underlying quantify the underlying downwards trend in admis-
trends in admissions.21 22 24 39 This is important as trends sions. We used 1 July 2002 as the start date, providing
seem to differ by age group,40 41 and only one study five years of pre-legislative data. Various additional
comprehensively adjusted for other risk factors, predictors were then included in the model to account
including temperature and flu rates.39 for variation in admissions for myocardial infarction
We addressed all these issues by examining the attributable to factors other than the implementation
impact of legislation on hospital admissions for myo- of smoke-free legislation.33-36 To model the temporal
cardial infarction in England, where all enclosed work- fluctuations, we used temperature, flu, week of year,
places and public places, with a few exceptions, and an indicator variable for the Christmas holidays
became smoke-free on 1 July 2007. (1 if it is the first or last week in the year and 0 other-
wise). Weekly temperatures were the mean of the daily
METHODS mean surface air temperatures obtained from the Cen-
Evaluating impacts of smoke-free England tral England Temperature data series.45 46 As prelimin-
Data ary exploration of the data suggested that the effects of
Hospital episode statistics (HES) data provide routi- temperature might be delayed,47 we considered two
nely collected information on all patients who receive predictors: temperature in the same week as the admis-
care from the National Health Service (NHS) in sion and temperature in the previous week. Weekly flu
England.42 Each completed record comprises a “fin- rates for England and Wales were obtained from the
ished consultant episode,” a period of time a patient Royal College of General Practitioners’ research and
spends under the care of one NHS consultant. We surveillance centre, which collects data on consulta-
extracted data for all finished emergency admission tions for flu-like illnesses from about 100 general prac-
episodes in those aged 18 and over living in England, tice surgeries, and log transformed before analysis.
with an admission date between 1 July 2002 (five years Temperature and flu rates were considered as linear
before the legislation) and 30 September 2008 terms in the model while week of year was included
(15 months after the legislation) and a primary diagno- as a cyclic cubic spline to capture any additional seaso-
sis of ICD-10 (international classification of disease, nal patterns that might be non-linear.
10th revision) code I21 (myocardial infarction).43 We The population estimate for England was included
retained only the first episode (known as the admission as an offset variable—namely, a predictor variable with
episode) of a patient’s stay in hospital because these a regression coefficient fixed at 1. This ensures there is
were more likely to reflect myocardial infarction a one to one relation between the population size and
events that had occurred outside of hospital rather the number of admissions. Weekly population esti-
than those occurring as complications of hospital treat- mates were obtained by linearly interpolating mid-
ment. In line with the ICD-10 code I21 definition of year population estimates for 2002 to 2007 and popu-
“myocardial infarction specified as acute or with a sta- lation projections for 2008 and 2009 provided by the
ted duration of 4 weeks (28 days) or less from onset”43 UK’s Office for National Statistics.
and to avoid duplicate admissions for the same event, Models were fitted in R.8.1 using the gam and gamm
we excluded any repeat admissions within a 28 day functions from the library mgcv.48 After adjustment for
period. Records missing data on age or sex were smoke-free legislation, number of days, and popula-
excluded from the analysis (less than 0.1% of records). tion size, we considered the other predictor variables
in a backwards selection procedure to identify the best
Statistical analyses model using the mgcv library’s unbiased risk estimator
Using an interrupted time series design, we developed (UBRE), an approximation to Akaikes Information
a segmented Poisson regression model44 to test the Criterion,49 to compare candidate models. Models
hypothesis that there was a change in the number of with a lower unbiased risk estimator are preferred.48
emergency admissions for myocardial infarction The suitability of the selected statistical model was
immediately after the introduction of smoke-free legis- assessed with plots of residuals, including an assess-
lation (that is, from Monday 2 July 2007 onwards). The ment of any remaining serial correlation in the resi-
response variable was the weekly number of admis- duals using autocorrelation plots. When necessary,
sions, with variation in week length (week 52 was presence of short term autocorrelation was modelled
eight days in a non-leap year and nine in a leap year) by applying a first order autoregressive AR(1) struc-
accounted for by including log number of days as a ture to the residuals.
predictor in the model. The impact of smoke-free leg- To assess differences in the impact of smoke-free leg-
islation, defined as a change in the rate of admissions islation among population subgroups, we stratified the
page 2 of 8 BMJ | ONLINE FIRST | bmj.com
3. RESEARCH
data by age (<60, ≥60) and sex and performed separate prevented over a 12 month period. Given that an initial
analyses on each group. We also examined whether myocardial infarction might result in several subse-
there was an increase or decrease in the slope of the quent emergency admissions to hospital, this equates
trend after the legislation, compared with pre-legisla- to around 1600 fewer emergency admissions. The sub-
tive trends, by adding an interaction term between the group analyses indicated that the legislation had an
binary predictor for smoke-free legislation and the lin- impact in men and women aged 60 and over, with a
ear predictor for time to the models. To provide further reduction of 3.07% (P=0.001) and 3.82% (P=0.007),
support for the findings we refitted the final models respectively. Men aged under 60 also showed a signifi-
using 16 false dates for smoke-free legislation ranging
from January 2005 to January 2007.
Implementation of smoke-free legislation
Predicting the number of events prevented Data used in analysis
We used the final Poisson regression model to predict Men aged <60
Mean No of daily admissions
40
the number of emergency admissions for myocardial
infarction that were prevented as a result of smoke-free
legislation in the first year of implementation. To esti- 35
mate the number of averted events Ne we subtracted the
regression based prediction of the number of events 30
from 1 July 2007 to 30 June 2008 (Nw) from the pre-
dicted number of events without the influence of the 25
legislation (Now). If β is the estimated regression coeffi-
cient for the smoke-free legislation predictor from the 20
final Poisson regression model, Now is equivalent to Nw/
exp(β). The total number of emergency admissions Women aged <60
Mean No of daily admissions
12
averted will be slightly higher than Ne because some
of the events result in multiple emergency readmis-
10
sions to hospital within 28 days, and we excluded
these readmissions from the main analysis. Therefore,
to predict the total number of emergency admissions 8
prevented we repeated the statistical analysis on a data-
set that included readmissions. 6
RESULTS 4
Between 2000 and 2008 there was a notable decrease in Men aged ≥60
the number of emergency admissions for myocardial
Mean No of daily admissions
90
infarction, a decrease that seems to have accelerated
from around 2002 and was greater in older than 80
younger age groups (figs 1 and 2). The seasonal pattern
observed was consistent with that reported
70
elsewhere, 33-36 with a peak in admissions over Christ-
mas and early spring, higher rates of admission over
60
winter, and lower rates in summer (fig 3). Indeed the
decline each summer was of a similar order of magni-
tude to the secular decline seen over the six year period 50
studied. Most admissions occurred in men and those Women aged ≥60
Mean No of daily admissions
70
aged over 60 with relatively few events in women aged
under 60 (table 1).
Of the predictor variables entered in the initial mod- 60
els, only flu, which was highly correlated with tempera-
ture, was dropped from all models. Temperature was 50
dropped from the models for those aged under 60 and
Christmas holidays from the model for men aged 40
under 60 (table 2). We added first order autoregressive
AR(1) terms to the final models for all people and for
30
women aged 60 and over to allow for short term auto- Jan Jul Sep
2000 2002 2008
correlation.
After the implementation of smoke-free legislation, Time
there was a significant drop of 2.4% (P=0.007) in the Fig 1 | Trends in weekly number of emergency admissions for
number of emergency admissions for myocardial myocardial infarction (average daily count) from January 2000
infarction (table 2). This implies that just over 1200 to September 2008 by age and sex. Note different ranges on y
emergency admissions for myocardial infarction were axis
BMJ | ONLINE FIRST | bmj.com page 3 of 8
4. RESEARCH
Table 1 | Number of emergency admissions* for myocardial infarction in England overall and by age group
Men Women
Year beginning 1 July All events <60 ≥60 <60 ≥60
2002 61 498 11 704 26 701 2746 20 347
2003 60 680 11 676 25 841 2718 20 445
2004 58 803 11 448 24 996 2635 19 724
2005 55 752 10 952 23 679 2627 18 494
2006 53 964 11 075 22 781 2636 17 472
2007 51 664 10 457 21 824 2536 16 847
*Only admissions that met study’s inclusion criteria.
cant drop in admissions of 3.46% (P<0.01), but the Secondly, our study methods differed, with potentially
regression analysis gave no indication of a decline in better control of confounding.
younger women (2.46%, P=0.38). There was no evi-
dence of a change in the slope of the trend line after Exposure before legislation
the legislation. Smoke-free legislation in England was introduced at a
By refitting the model with false dates for smoke-free time when many public places and workplaces were
legislation, we found that none of the false dates led to a already smoke-free. In the year before implementa-
significant impact in the population as a whole or in tion, a nationally representative survey (ONS Omni-
men of any age. In women aged over 60, however, bus Survey) indicated that 55% of employed adults in
modelling with all but one of the false dates from the England already worked in a smoke-free environment.
end of 2005 to 2007 yielded significant results. In addition, some bars and restaurants, the venues
most affected by the legislation, went smoke-free
DISCUSSION before 1 July. Therefore, despite high compliance
Hospital admissions for myocardial infarction with the legislation,51 the decline in smoke exposure
dropped significantly after the introduction of smoke- and the resulting health benefits of smoke-free legisla-
free legislation in England. After adjustment for the tion that occurred immediately after the implementa-
pre-existing decline in admissions, trends in popula- tion of legislation are likely to have been less marked
tion size, and seasonal variation in admissions, we than those observed elsewhere, making them harder to
found a 2.4% drop in the number of emergency admis- detect in a study such as this. A similar issue was noted
sions for myocardial infarction after the legislation. in New York, where various pre-existing smoking
This equates to 1200 fewer emergency admissions for restrictions were in place.21
myocardial infarction in the first year after the law Levels of exposure to secondhand smoke were
came into effect (1600 including readmissions). around 50% lower in England than in Scotland just
We identified a smaller reduction than other studies. before implementation of legislation in each country,
We believe there are two main explanations for this. whether measured by concentrations of particulate
Firstly, exposure to secondhand smoke immediately matter in bars50 or cotinine concentrations (a biochem-
before legislation was substantially lower in England ical marker of smoke exposure) in non-smoking bar
than in other jurisdictions because of marked declines workers50 and the general public.52 53 While this might
in population exposure in advance of the legislation.50 be partly explained by the introduction of legislation in
England in summer and in Scotland in winter, the fact
Implementation of smoke-free legislation that the collection periods for the population data over-
Data used in analysis lap in the two jurisdictions and that greater absolute
declines in exposure were seen in Scotland suggest
Mean No of daily admissions
200
this cannot be the whole explanation.
180 Data on cotinine concentrations from population
surveys indicates that population exposure to second-
160 hand smoke in England has declined markedly since
the mid-1990s. From 1993 to 2003 cotinine concentra-
tions almost halved in non-smoking adults living with
140
non-smoking partners and declined by a third in those
living with smoking partners.54 In children, for whom
120
Jan Jul Sep more recent data on cotinine are available, there has
2000 2002 2008 been a 59% decline in exposure between 1996 and
Time 2006, with the largest annual decline in the year imme-
Fig 2 | Trends in overall weekly number of emergency
diately before smoke-free legislation.55 If levels of
admissions for myocardial infarction (average daily count) exposure in adults have continued to decline, in line
from January 2000 to September 2008. Note, weekly numbers with those of children, some of the underlying decline
of admissions are sum of four graphs in figure 1 in admissions to hospital for myocardial infarction
page 4 of 8 BMJ | ONLINE FIRST | bmj.com
5. RESEARCH
Table 2 | Results of Poisson regression analyses to detect association between smoke-free legislation in England and emergency admissions for myocardial
infarction
Men Women
Final models* All events <60 ≥60 <60 ≥60
% change after smoke-free legislation† (95% CI) −2.37‡ (−4.06 to −0.66) −3.46‡ (−5.99 to −0.85) −3.07‡ (−4.86 to −1.25) −2.46 (−7.62 to 3.00) −3.82‡ (−6.48 to −1.09)
Other predictors kept in analysis:
Time (long term trend) Yes Yes Yes Yes Yes
Temperature§ Yes No Yes No Yes
Flu No No No No No
Christmas holidays Yes No Yes Yes Yes
Week of year Yes Yes Yes Yes Yes
Residuals:
AR(1) model Yes No No No Yes
*All regression models were adjusted for population size, number of days, and smoke-free legislation.
†Calculated by exponentiating estimated regression coefficient for smoke-free legislation predictor.
‡P<0.01.
§In previous week.
before July 2007 is probably due to reductions in popu- of coronary heart disease might have contributed to
lation exposure to secondhand smoke. Moreover, the changes observed. By accounting for the underly-
given that some of the decline in exposure is probably ing decline in emergency admissions for myocardial
attributable to smoke-free legislation either indirectly infarction, seasonal patterns, and other risk factors
(for example, through changes in behaviour triggered (which few other studies have controlled for)39 we will
by growing public debates over secondhand smoke) or produce a more conservative assessment of the contri-
directly (public venues going smoke-free in advance of bution of smoke-free public places to reducing the
1 July), studies such as this, designed to detect changes number of emergency admissions. Although this
immediately after implementation, will underestimate might more accurately reflect the immediate impact
impacts. of the implementation of the smoke-free law in Eng-
land, for the reasons identified above, our estimate
Differences in methods will miss the contribution of the legislation to the pre-
The second explanation for the more modest decline legislative declines in exposure to secondhand smoke
found in our study relates to differences in methods. and will thus underestimate its full impact.
Several of the earlier studies used a “before and after”
study design, and, although some used geographical Validity and age, sex differences
controls, they might have been unable to fully account Although our reported impacts were significant
for underlying trends in admissions for myocardial (P<0.01 in all but women aged under 60), the confi-
infarction. Given the marked decline observed in dence intervals were close to the null effect. There is,
admissions from 2002 onwards in our data, consistent however, substantial reason for believing the decline in
with similar declines observed elsewhere,26-32 this admissions is valid. It is biologically plausible, as out-
might account for the greater reductions seen in such lined above, and robust to the “false dates” analysis in
studies. Moreover, even if the before and after periods all but older women (discussed below). Moreover,
of these studies spanned the same months, bias from when we imputed smoking prevalence and self
unseasonal weather patterns and fluctuations in the reported data on exposure from the Health Survey for
prevalence of other factors known to influence rates England56 into a mathematical model developed by
Richiardi et al57 to predict the impact of smoke-free
legislation on admissions for myocardial infarction,
Mean No of daily admissions
180
the predicted reductions in admissions were between
3.6% and 10.9% in men and 2.4% and 7.2% in women.
170
Our results are therefore consistent with the lower esti-
mates obtained from the Richiardi model.57
160
Impacts were observed in men regardless of age,
while in women we found a significant impact only
150 among those aged 60 or over in whom some of the
“false dates” also led to significant findings, indicating
140 uncertainty around the impacts in this group. Although
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
many studies do not examine impacts by sex,18-21 37 the
Month absence of an impact in women was also seen in
Fig 3 | Trends in overall weekly number of emergency Rome39 and in four other Italian regions.22 Three issues
admissions for myocardial infarction (average daily count) are worth considering here. Firstly, given that it was
averaged across years only the false dates during the 18 months before the
BMJ | ONLINE FIRST | bmj.com page 5 of 8
6. RESEARCH
legislation that were significant, this could suggest, in control population with similar demographics was
line with the issues raised above, that exposure to sec- not feasible. But even if a control population had
ondhand smoke was already declining in women and been available, confounding would not have been
the false positives might therefore reflect a real, albeit completely removed if an unusual event had occurred
gradual, reduction in myocardial infarction attributa- in only one population.
ble to gradual declines in exposure. Secondly, both Aggregating individual admissions data to the
pre-legislative levels of, and reductions in, self reported national level meant we could consider only national
exposure to secondhand smoke were lower in women level covariates. This prevented us from including
than men.56 Thirdly, as a result of their low numbers of local level covariates, such as temperature and air pol-
admissions, there was insufficient power in the analysis lution, in the model.61 62 Although this is unlikely to be
of women aged under 60 to detect the small impacts a key concern for temperature given the high correla-
observed in men. Power calculations show that drops tion documented between the Central England Tem-
between 2-3% can be detected with high power (80%) perature data series and the temperature at individual
in all other population subgroups, but in women aged weather stations,63 it illustrates that residual confound-
under 60, only reductions greater than 7.5% could be ing from unknown factors might remain. Finally, we
detected with comparable power. As such, we can be were able to explore only the short term impact of
confident only that there was no reduction greater than the legislation, and it is possible that the impact on
7.5% in this subgroup. Whatever the reasons, the admissions for myocardial infarctions might vary
results in women must clearly be treated with caution. over time, with two recent reviews suggesting that
impacts could increase over time.14 15
Limitations
The main weakness of our study, common to most Strengths
other studies on this topic,18-22 24 25 37-39 was that we Despite these concerns, we believe our study has sev-
relied on routine hospital data. Such data do not eral strengths and advantages over existing studies.
include the smoking status of patients, and we were With a population of 49 million (2001 census), England
therefore unable to determine how much of the decline is the largest jurisdiction yet to go smoke-free. By using
after the legislation was attributable to reduced expo- a comprehensive national dataset we were therefore
sure to secondhand smoke and how much to reduc- able to provide a study population considerably larger
tions in active smoking. This is something we are than those of previous studies, which range from 19
currently investigating through analysis of another million (New York State),21 through 2-5 million (New
dataset. Zealand,24 parts of Italy,22 25 39 and Scotland23), to less
Furthermore, definitions of and thresholds for diag- than 200 000 (jurisdictions in US18-20 38 and Canada37)
nosing myocardial infarction have changed over and thus to offer greater statistical power to detect an
time,58 but the impact of this on routine records of hos-
impact in such a short time scale. We estimate that the
pital admissions is not fully understood.59 A redefini-
smallest reduction detectable with a power of 0.8, often
tion of myocardial infarction occurred in 2000,
considered the desirable level of power, is almost 2%.
wherein greater emphasis was placed on the use of spe-
This is important because other jurisdictions that, like
cific biochemical markers (notably troponin).60 This
England, have partial smoke-free restrictions in place
was predicted to lead to an increase in the number of
before comprehensive legislation might be unable to
diagnosed myocardial infarctions, albeit on a gradual
detect changes this small because of their smaller popu-
basis as the availability of troponin assays gradually
lations and thus sample sizes. Furthermore, the robust
increased.59 Although we observed no marked
segmented Poisson regression analysis, to a greater
increase in admissions between 2000 and 2002 nor
extent than most previous studies, was able to mini-
from 1997 to 2000 (data not shown), we chose to exam-
mise confounding by accounting for underlying trends
ine data from 2002 onwards to allow for any change in
in population size and admissions for myocardial
diagnostic threshold to take effect. In this way, and by
infarction and potential confounders such as season,
including a linear predictor for time in our model, we
temperature, flu, and holidays.
hoped to capture any gradual change that might have
occurred as best we could. We therefore conclude that the implementation of
Reductions in hospital admissions for myocardial smoke-free public places is associated with significant
infarction might also be explained by increases in reductions in hospital admissions for myocardial
deaths from myocardial infarction outside hospital. infarction even in jurisdictions with pre-existing smok-
Studies in Europe that have examined this issue, how- ing restrictions. Given the large number of myocardial
ever, found a reduction in out of hospital deaths for infarction events per year, even the relatively small
coronary events accompanying the corresponding reduction seen in England has important public health
decline in admissions,23 39 and this is therefore unlikely benefits.
to be a concern. We are grateful to the Association of Public Health Observatories, in
Given that England was the last part of the UK to particular Bobbie Jacobson, Paul Brown, and Davidson Ho for their
support, and to the Health Protection Agency for providing the flu data.
implement national smoke-free legislation (Scotland The HES data were made available by the NHS Health and Social Care
in March 2006, Wales and Northern Ireland in April Information Centre. We also thank Alan Kelly and Stephen Babb for their
2007), an assessment of the impact compared with a comments on early drafts of this paper.
page 6 of 8 BMJ | ONLINE FIRST | bmj.com
7. RESEARCH
10 Pope CA 3rd, Burnett RT, Krewski D, Jerrett M, Shi Y, Calle EE, et al.
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Secondhand smoke increases the risk of acute myocardial infarction relationship. Circulation 2009;120:941-8.
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attacks. Prev Med 2007;45:9-11.
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Contributors: AG developed the research proposal and is the principal infarction associated with a citywide smoking ordinance. Circulation
investigator. AG and MS planned the analysis, drafted and edited the 2006;114:1490-6.
paper, and are guarantors. MS undertook the analysis. RM contributed to 19 Khuder SA, Milz S, Jordan T, Price J, Silvestri K, Butler P. The impact of
a smoking ban on hospital admissions for coronary heart disease.
data preparation, study design, and editing of the paper. LB contributed
Prev Med 2007;45:3-8.
to the funding proposal, drafting, and editing of the paper. 20 Sargent RP, Shepard RM, Glantz SA. Reduced incidence of
Funding: This work was undertaken by the University of Bath, which admissions for myocardial infarction associated with public smoking
received funding from the Department of Health’s Policy Research ban: before and after study. BMJ 2004;328:977-80.
Programme. The views expressed in the publication are those of the 21 Juster HR, Loomis BR, Hinman TM, Farrelly MC, Hyland A, Bauer UE,
authors and not necessarily those of the Department of Health. AG is et al. Declines in hospital admissions for acute myocardial infarction
supported by a Health Foundation Clinician Scientist Fellowship. MS, LB, in New York State after implementation of a comprehensive smoking
and AG are members of the UK Centre for Tobacco Control, a UKCRC ban. Am J Public Health 2007;97:2035-9.
Public Health Research: Centre of Excellence. Funding from the British 22 Vasselli SPP, Gaelone D, Spizzichion L, De Campora E, Gnavt R,
Saitto C, et al. Reduction incidence of myocardial infarction
Heart Foundation, Cancer Research UK, Economic and Social Research
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Council, Medical Research Council and the Department of Health, under Cardioangiol 2008;56:197-203.
the auspices of the UK Clinical Research Collaboration is gratefully 23 Pell JP, Haw S, Cobbe S, Newby DE, Pell ACH, Fischbacher C, et al.
acknowledged. The funders played no role in the study design, analysis, Smoke-free legislation and hospitalizations for acute coronary
and interpretation of data nor in the writing of the report or the decision to syndrome. N Engl J Med 2008;359:482-91.
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Competing interests: All authors have completed the Unified Competing et al. After the smoke has cleared: evaluation of the impact of a new
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Financial support for the submitted work as detailed above; (2) No Italian smoking regulation on rates of hospital admission for acute
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interest in the submitted work; (3) No spouses, partners, or children with et al. Decline in incidence of hospitalisation for acute myocardial
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