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Bleeding disorders
- 1. Good morning
- 3. • • • • • • Idiopathic thrombocytopenic purpura Hemophilia Vitamin k deficiency Neonatal alloimmune thrombocytopenia Disseminated intravascular coagulation Henoch- Schonlein Purpura
- 10. Fanconi anemia
- 12. EXAMINATION
- 13. LAB DIAGNOSIS
- 14. MANAGEMENT
- 15. C/C ITP
- 17. HEMOPHILIA
- 20. PROPHYLAXIS
- 24. DIAGNOSIS
- 28. MANAGEMENT
- 31. PATHOPHSIOLOGY
- 33. • • • • • Wide spread deposition of fibrin Ischemia Microangiopathic hemolytic anemia Consumption Activation of plasminogen
- 34. • Cleaves fibrin • Digest V and VIII • FDP inhibit platelet aggregation,fibrin polymerisation,thrombin • Bleeding diathesis
- 35. Causes
- 36. Medical • • • • • • • • • • Septicemia Fulminant hepatic failure Heat stroke,burns Malignancy Reye syndrome Hereditary protein c deficiency Snake bite HUS Kawasaki disease Collagen Vascular disease •Solid tumour •Bacterial •Liver cirrhosis •Viral •Kasabach Meritt Syndrome •Parasitic •Mycotic •rickettsial
- 37. Surgical • Severe renal graft •Vascular tumour rejection •Aortic aneurysm • Severe trauma • Multiple fracture • Major operations • Brain injury
- 39. meningococcemia
- 43. TREATMENT
- 45. Henoch- Schonlein Purpura • Common vasculitides • Non thrombocytopenic purpura, transient arthralgia, abdominal symptoms
- 46. Manifestations • Macular rash on lower extremities and buttocks • Isolated hematuria, hypertension, nephritic/nephrotic syndrome • Intermittent colicky, periumbilical abdominal pain • Vomiting
- 47. • • • • Clinical diagnosis Skin biopsy Indirect immunofluorescence USG abdomen
- 48. Treatment • Hydration and pain relief • Prednisolone Indications: Life Threatening Intestinal Hemorrhage, Obstruction, Perforation, Intussusceptions
Editor's Notes
- Thrombin generation extrinsic pathway-tissue factors accumulate in activated platelets-thrombin generationThrombin amplifies inflammation and clotting-platelets, V, VIII,fibrinogen,VIII,activablefibrinolysis inhibitorSupression of fibrinolysis-increase plasma level of PAI 1
- Diffuse abdominal pain,biopsy IgA deposition,arthritis or arthralgia,renal involvement