BST filed its Form 1-A for a tier 2 Reg. A Offering to commercialize its patented minimally invasive treatment of obesity, metabolic syndrome and type 2 diabetes.
BST filed its Form 1-A for a tier 2 Reg. A Offering to commercialize its patented minimally invasive treatment of obesity, metabolic syndrome and type 2 diabetes.
Healthy Savings. Medical Technology and the Economic Burden of DiseaseRevital (Tali) Hirsch
As America ages and sedentary lifestyles and unhealthy diets become more common, experts agree the nation is suffering a sharp rise in the prevalence of chronic disease. As the 21st century unfolds, technology – in the form of advanced diagnostic and therapeutic devices -- can meet the need for early detection and more effective management of illness. Some researchers, however, have questioned whether the overall benefit of technical advances outweighs the costs -- a question this report definitively answers.
Accordingly, researchers at the Milken Institute undertook a comprehensive, quantitative documentation of medical technology's impact on the economic burden of disease. The study also projects how future innovation in this sector would affect the health care system and the larger economy -- a positive benefit of more than $23 billion a year for the United States.
The study takes a systematic approach to documenting the full costs and broader economic benefits of health care investments by examining innovations pertaining to four prevalent causes of disability and death: heart disease, diabetes, colorectal cancer, and musculoskeletal disease. The report considers therapeutics and diagnostic devices that are widely used and have substantially affected the lives of patients as well as the overall U.S. economy. Among the 10 devices or device-based procedures studied are pacemakers, insulin infusion pumps, colonoscopies, and joint replacement surgery.
The data demonstrate that the use of medical technology brings considerable economic benefits. These are seen in both aggregate savings in treatment expenditures and prevention as well as the reduction of "indirect impact" through larger contributions to the economy.
UBTech CySure
Declarations
1
This insurance policy includes this Policy Declarations Page, Cyber Coverage Forms and Endorsements.
The Insuring Agreements included in the coverage forms are provided on a Claims-Made basis, and
coverage will only apply to Claims first made during the Policy Period, or optional extended reporting
period.
The insurer (UBTech CySure) has the duty to defend Claims.
Policy Limits: All coverages provided by this policy are within the Aggregate Limit indicated below. The
Aggregate Limit will be reduced by claim expenses, and may be completely exhausted.
Carrier Type: This insurer is non-admitted and provides coverage in accordance with applicable laws and
regulations.
If the “Limit” next to any coverage listed in the Declarations page is blank, that coverage is not included.
Coverages may be sublimited below the policy aggregate limit and all sublimits will be listed in the limits
section of this policy Declarations.
Insurer UBTech CySure (Please use this instead of Travelers)
Named Insured ABC Consultants
Principal Address 123 Main Street, Baltimore, MD 21010
Policy Period Inception Date: October 20, 2022 (12:01 Local Time at Principal Address)
Expiration Date: October 20, 2023 (12:01 Local Time at Principal Address)
Retroactive Date Full Prior Acts
Policy Premium $20,000
Taxes $1,000
Policy Fee $250
Total: $21,250
Claims All claims should be reported to [email protected]
Claims may also be reported by phone at 1-800-###-####
Insurance Producer
(Agent or Broker)
Main Street Brokers
321 Court Street, Baltimore, MD 21210
UBTech CySure
Declarations
2
UBTech CySure Policy Aggregate Limit: $2,000,000
The limit listed here is shared by the coverages listed below. All claims are within this Policy Aggregate
Limit
Liability Coverages Limit Retention/Deductible
Privacy & Security $2,000,000 $10,000
PCI Fines & Penalties - -
Media Liability $2,000,000 $10,000
Regulatory Proceedings $2,000,000 $10,000
Regulatory Fines & Penalties $2,000,000 $10,000
Breach Response Coverages Limit Retention/Deductible
Privacy Breach Notification $2,000,000 $10,000
Computer & Legal Experts $2,000,000 $10,000
Betterment $25,000 $10,000
Cyber Extortion $1,000,000 $10,000
Data Restoration $2,000,000 $10,000
Public Relations $2,000,000 $10,000
Business Loss Coverages Limit Waiting Period Period of Restoration
Business Interruption $2,000,000 12 Hours 180 Days
Dependent Business Interruption $1,000,000 12 Hours 180 Days
Reputational Harm - - -
Cybercrime Coverages Limit Retention/Deductible
Computer Fraud $100,000 $10,000
Funds Transfer Fraud $100,000 $10,000
Social Engineering Fraud $50,000 $10,000
Telecommunication Fraud $100,000 $10,000
Endorsements
Endorsement # Endorsement Name Form #
1 OFAC Due Diligence CYSURE-.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Similar to BioSculpture Investor Presentation Highlights (8 1-17, public)
Healthy Savings. Medical Technology and the Economic Burden of DiseaseRevital (Tali) Hirsch
As America ages and sedentary lifestyles and unhealthy diets become more common, experts agree the nation is suffering a sharp rise in the prevalence of chronic disease. As the 21st century unfolds, technology – in the form of advanced diagnostic and therapeutic devices -- can meet the need for early detection and more effective management of illness. Some researchers, however, have questioned whether the overall benefit of technical advances outweighs the costs -- a question this report definitively answers.
Accordingly, researchers at the Milken Institute undertook a comprehensive, quantitative documentation of medical technology's impact on the economic burden of disease. The study also projects how future innovation in this sector would affect the health care system and the larger economy -- a positive benefit of more than $23 billion a year for the United States.
The study takes a systematic approach to documenting the full costs and broader economic benefits of health care investments by examining innovations pertaining to four prevalent causes of disability and death: heart disease, diabetes, colorectal cancer, and musculoskeletal disease. The report considers therapeutics and diagnostic devices that are widely used and have substantially affected the lives of patients as well as the overall U.S. economy. Among the 10 devices or device-based procedures studied are pacemakers, insulin infusion pumps, colonoscopies, and joint replacement surgery.
The data demonstrate that the use of medical technology brings considerable economic benefits. These are seen in both aggregate savings in treatment expenditures and prevention as well as the reduction of "indirect impact" through larger contributions to the economy.
UBTech CySure
Declarations
1
This insurance policy includes this Policy Declarations Page, Cyber Coverage Forms and Endorsements.
The Insuring Agreements included in the coverage forms are provided on a Claims-Made basis, and
coverage will only apply to Claims first made during the Policy Period, or optional extended reporting
period.
The insurer (UBTech CySure) has the duty to defend Claims.
Policy Limits: All coverages provided by this policy are within the Aggregate Limit indicated below. The
Aggregate Limit will be reduced by claim expenses, and may be completely exhausted.
Carrier Type: This insurer is non-admitted and provides coverage in accordance with applicable laws and
regulations.
If the “Limit” next to any coverage listed in the Declarations page is blank, that coverage is not included.
Coverages may be sublimited below the policy aggregate limit and all sublimits will be listed in the limits
section of this policy Declarations.
Insurer UBTech CySure (Please use this instead of Travelers)
Named Insured ABC Consultants
Principal Address 123 Main Street, Baltimore, MD 21010
Policy Period Inception Date: October 20, 2022 (12:01 Local Time at Principal Address)
Expiration Date: October 20, 2023 (12:01 Local Time at Principal Address)
Retroactive Date Full Prior Acts
Policy Premium $20,000
Taxes $1,000
Policy Fee $250
Total: $21,250
Claims All claims should be reported to [email protected]
Claims may also be reported by phone at 1-800-###-####
Insurance Producer
(Agent or Broker)
Main Street Brokers
321 Court Street, Baltimore, MD 21210
UBTech CySure
Declarations
2
UBTech CySure Policy Aggregate Limit: $2,000,000
The limit listed here is shared by the coverages listed below. All claims are within this Policy Aggregate
Limit
Liability Coverages Limit Retention/Deductible
Privacy & Security $2,000,000 $10,000
PCI Fines & Penalties - -
Media Liability $2,000,000 $10,000
Regulatory Proceedings $2,000,000 $10,000
Regulatory Fines & Penalties $2,000,000 $10,000
Breach Response Coverages Limit Retention/Deductible
Privacy Breach Notification $2,000,000 $10,000
Computer & Legal Experts $2,000,000 $10,000
Betterment $25,000 $10,000
Cyber Extortion $1,000,000 $10,000
Data Restoration $2,000,000 $10,000
Public Relations $2,000,000 $10,000
Business Loss Coverages Limit Waiting Period Period of Restoration
Business Interruption $2,000,000 12 Hours 180 Days
Dependent Business Interruption $1,000,000 12 Hours 180 Days
Reputational Harm - - -
Cybercrime Coverages Limit Retention/Deductible
Computer Fraud $100,000 $10,000
Funds Transfer Fraud $100,000 $10,000
Social Engineering Fraud $50,000 $10,000
Telecommunication Fraud $100,000 $10,000
Endorsements
Endorsement # Endorsement Name Form #
1 OFAC Due Diligence CYSURE-.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. REGULATION A+ Allows companies to raise up to $50M from retail investors in an SEC registered offering.
REGULATION D - RULE 506(c) Allows companies to raise capital from accredited investors only and market the offering.
BIOCULPTURE TECHNOLOGY, INC. (“BIOCULPTURE”) HAS LAUNCHED A TEST THE WATERS CAMPAIGN FOR
A REGULATION A+ OFFERING. WE ARE NOW ACCEPTING NON-BINDING INDICATIONS OF INTEREST
(RESERVATIONS)
NO MONEY OR OTHER CONSIDERATION IS BEING SOLICITED FOR OUR REGULATION A+ OFFERING AT THIS
TIME AND IF SENT IN TO BIOCULPTURE WILL NOT BE ACCEPTED. NO OFFER TO BUY SECURITIES IN A
REGULATION A+ OFFERING OF BIOCULPTURE CAN BE ACCEPTED AND NO PART OF THE PURCHASE PRICE
CAN BE RECEIVED UNTIL BIOCULPTURE’S OFFERING STATEMENT IS QUALIFIED. ANY SUCH OFFER TO BUY
SECURITIES MAY BE WITHDRAWN OR REVOKED, WITHOUT OBLIGATION OR COMMITMENT OF ANY KIND,
AT ANY TIME BEFORE NOTICE OF ITS ACCEPTANCE GIVEN AFTER THE QUALIFICATION DATE. ANY
INDICATIONS OF INTEREST IN BIOCULPTURE’S OFFERING INVOLVES NO OBLIGATION OR COMMITMENT OF
ANY KIND.
PRIVATE PLACEMENT RULE 506(C) OFFERING
AN INVESTMENT IN BIOCULPTURE THROUGH PRIVATE PLACEMENT IN OUR 506(C) OFFERING MAY ONLY BE
MADE BY ACCREDITED INVESTORS THROUGH THIRD PARTY VERIFICATION AND WRITTEN CONFIRMATION
FROM ONE OF THE FOLLOWING: A REGISTERED BROKER DEALER, A REGISTERED INVESTMENT ADVISOR, A
LICENSED ATTORNEY OR A CPA, THAT THEY HAVE VERIFIED ACCREDITED INVESTOR STATUS IN THE LAST
THREE MONTHS, WITH AND FOLLOWING REVIEW OF A CONFIDENTIAL PRIVATE PLACEMENT
MEMORANDUM. THIS PACKAGE OF INFORMATION IS NOT MEANT TO REPLACE OR SUPPLEMENT THE
CONFIDENTIAL PRIVATE PLACEMENT MEMORANDUM.
Disclaimer 1
3. Forward Looking Statements
Any forecasts and pro forma financial information contained herein
or which are part of the Company’s business plan, are for illustrative
purposes only and are based upon assumptions made by Management
regarding hypothetical future events.
Management believes these assumptions are reasonable and
furthermore to the best of its knowledge that all the facts contained
herein are true and there are no material errors or omissions.
There is no assurance that actual events will correspond with the
assumptions or that factors beyond the control of the Company will not
affect the assumptions and adversely affect the illustrative value and
conclusions of any forecasts.
2
4. BioSculpture Technology, Inc. Company Profile
Company Profile Key Financials
BioSculpture Technology, Inc. (“BST”) is a
commercial-stage medical device manufacturer
developing a patented minimally invasive method
and device for the endoscopic removal of visceral
or “belly” fat as a new treatment of obesity,
metabolic syndrome and type 2 diabetes mellitus.
Large IP portfolio: 3 patents on method and device
with numerous more U.S. pending.
Proven concept: first generation of successful
technology was licensed to UAM, NuMed, Byron
Medical/Mentor/Ethicon generated $150 MM in
revenues annually.
Small & medium volume
liposuction
Airbrush®
Liposculptor III
Airbrush®
Liposculptor IIE EVL®
Medium & Large volume
liposuction
Precision liposuction
Endoscopic Visceral
Lipectomy
FME 5/31/17 $1,000‘s
2017 2018 2019 2020 2021
SALES $0 $3,017 $16,222 $24,181 $33,880
EBITDA ($1,942) ($270) $1,844 $3,042 $4,547
NET INCOME($1,978,936) ($318,144) $1,796,303 $2,994,106 $3,042,199
3
5. Experienced Management Team
Name Title Background
Robert L.
Cucin, MD,
FACS
Founder,
President
& CEO
Inventor of both PAL and TCAL; board-certified plastic and reconstructive
and general surgeon.
BA (Cornell), M.D. (Cornell), JD (Fordham), MBA (Columbia).
18 patents, 5 books, 24 articles, and one ballet score.
Founded and Directs Rocin Laboratories, Inc., a biomedical Research and
Development company which licensed his first liposuction patent non-
exclusively to NuMed, UAM, Byron Medical, Mentor, and Ethicon.
Founded and directed Plastic Surgical Research to support IACUC studies
and clinical IRB’s carried out at academic centers.
Founded and Directed the American Institute of Plastic Surgery (NYC).
Licensed Securities professional: Series 4, Series 7, Series 24, Series 27, Series
63, Series 65, Series 79, Series 86/87, Series 99.
Deborah
Salerno
CFO Currently holds 7, 24, 63 and 79 Securities licenses.
Managing Director of DAS Consulting LLC.
She been active in PIPEs and provides expertise in the alternative Public
Offerings market as well as traditional banking.
Simon
Taylor, Esq.
Corporate
Counsel
Columbia University and Harvard Law School graduate with broad
experience with biotechnology and medical devices, technology and IP start-
ups and ramp-ups, and venture financing.
Former Partner of Snow Becker Krauss.
4
6. Advisory Board
Name Title Background
Peter
Ciriscioli,
BS MS PhD
Engineering
Consultant
BS and MS in Materials Science and Engineering from the University of
California and a PhD in Mechanical Engineering from Stanford University.
Director of JLTV Programs for BAE Systems, Program Manager of the
Engineering Mechanics Laboratory at General Electric Corporate Research.
Director of Research for the Fiberite Corporation where he led 30 engineers
and scientists in U.S., U.K. and Europe and was responsible for the strategy
and implementation of new technologies and products.
4 patents, two books, and more than 20 published journal articles.
Brigadier
General
Richard B.
Yules, MD
Medical
Advisor
Yale B.S. and M.D, Board-certified otolaryngologist, having completed
surgical residences at Stanford and Harvard universities, where he still
maintains a faculty position.
Air National Guard assistant to the deputy assistant secretary of defense
Pentagon, Washington, D.C.
Published over fifty manuscripts and chapters, including four books.
Sits on the Board of several public and private companies.
Thomas J.
Perkowski,
Esq.
Patent
Prosecution
B.S. E.E Clarkson College of Technology
J.D. Franklin Pierce Law Center of Concord, New Hampshire.
Former Associate of Hopgood, Calimafde, Judlow and Mondolino (NYC)
Successfully prosecuted over 650 patents
5
7. Large Growth Opportunity
Liposuction
Large Addressable Market
2/3 of the U.S. population is overweight; 1/3 is frankly obese; forecast to grow to 43% in
few years.
2.1B obese people Worldwide forecast to grow to 50% of the world’s population by 20301
Obesity related disease yearly expenditures exceed $2T worldwide.1
Nearly $14B spent on cosmetic procedures in 2015, 5% increase from 20142.
$668M spent on liposuction in 2015 (4.8%).
$3,009 average surgeon’s fee / procedure in 2015.
Traditional liposuction and all other devices are
technologically limited to small and medium
volume subcutaneous fat removal.
Disruptive technology: BST’s Twin-Cannula
Assisted Liposuction (“TCAL”) allows
liposuction to become an operation of pounds
rather than inches.
Bariatric Treatment
A safer and faster alternative to current
restrictive or bypass bariatric surgery.
No cutting into the stomach, bowel or
rearranging alimentary plumbing.
Less invasive with no foreign body to erode
esophagus or skin, or cause malabsorption
syndromes and diarrhea (no quality of life
compromise).
Bariatric surgeries reached 220,000 in 2008.
Bariatric surgery spending $1.5B in 2016.
1. McKinsey Global Institute report released 11/20/14.
2. American Society of Plastic Surgeons report released 3/9/16.
6
8. Bazzocchi, A Diano, D Battista G How Fat is Fat? Lancet 380:e1 (2012)
Visceral fat removal Subcutaneous fat removal
Different Fat Requires Different Treatments
Endoscopic Visceral Lipectomy with EVL® Liposuction with Airbrush® Liposculptor IIE
Accumulation of subcutaneous and visceral types of fat has different consequences for
human body and EVL® and Airbrush® Liposculptor IIE provide viable and economic
solutions for effective removal of both types of fat
7
9. Product Overview
Airbrush®
Liposculptor III
Airbrush®
Liposculptor IIE EVL®
Application
Cosmetic & liposuction Cosmetic & liposuction Treatment & Visceral lipectomy
Obese patients, overweight patients
with elevated waist-to-hips ratios,
(~2B people, 43% of population)
$1,700 per procedure, 84% margin
Small and medium volume
liposuction (1/3 the population)
$ 100 per procedure, 80% margin
Medium and large volume
liposuction (1/3 population)
$100 per procedure, 80% margin
Insurance
No, out-of-pocket, discretionary
procedure
No, out-of-pocket, discretionary
procedure
Yes, reimbursed, indicated
procedure as well as still
discretionary (or proactive)
procedure
Purchaser
Dermatologists, plastic surgeons
and general surgeons performing
liposuction
Plastic surgeons, gynecologists &
general surgeons performing
liposuction
General and bariatric surgeons who
do endoscopic procedures
Market Size $500M device, up to $1B surgical fees can be targeted with single use
per-procedure consumables
$1.4B/yr. and expandable up to the
$2T/yr. obesity-related disease
expenditures
Patent & Method Protected Products
8
10. Adjustable reciprocation stroke (1.3 -2”).
Eliminates surgeon’s need to stroke the
cannula, saving labor and time while
improving consistency and control.
No vibration since outer cannula is
stationary.
Gentler on surgeon and patient as inner
cannula doesn’t traumatize patient since
it is ensheathed in stationary outer one
Intellimotion® control with feedback
closed loop DSP control and magnetic
coupling safe guards.
× Only vibrates (1/4”).
× Surgeon must still manually reciprocate
the cannula to aspirate fat.
× Vibration annoying to surgeon and can
cause carpal tunnel syndrome and tennis
elbow.
× Patient sustains trauma from 10’s of
1,000’s of advancing cannula impacts.
× We also invented this technology but
developed and adopted labor saving
tube-within-a-tube designs.
Airbrush® Advantage
Single Cannula Power Assisted Liposuction Twin Cannula Assisted Liposuction
Vibrates externally
9
11. Competitive Positioning of Liposuction Products
Airbrush® II & IIE
(TCAL)
Airbrush® III
PAL (Power
Assisted
Liposuction)
UAL (Ultrasound
Assisted
Liposuction)
LAL (LASER
Assisted
Liposuction)
Stroke Power-assisted Power assisted Manual Manual Manual
Action Twin Cannula,
adjustable long Stroke
II: 2” eliminates
surgeon’s manual
stroke; electric
Single cannula, short
stroke: 3/8” option of
rotation; twin cannulas
possible; assists
surgeon’s manual
stroke, electric
Single cannula vibrates
(~1/8”) at 4KHz; gas
and electric
Single cannula vibrates
<1/10” at 40KHz to
melt fat
Fiber directs laser light
source to melt fat
Vibration Vibration minimized
by tube-within-tube
design both in front,
also in rear IIE
Vibration minimized
by stationary barb
Heavy vibration; tubing
moves with cannula,
repetitive stress injury
not common
No aspiration: must
remove fat manually
after strokes
No aspiration; must
remove fat manually
after strokes
Risk of Burns None None None Significant if surgeon
moves hot tip too
slowly
Significant if surgeon
moves hot tip too
slowly
Tissue
Trauma
Gentler twin-cannula
design minimizes
tissue trauma
Single cannula designs
minimize tissue trauma
and twin-cannula
version possible to
minimize it further.
Vibrating tip
traumatizes tissue
Hot tip causes cellular
injury
Hot tip causes cellular
injury
Curved
Cannulas
Possible, prototyped
and ready for roll out
Possible on twin
cannula version
Impossible Impossible Impossible
Price $50,000 $9,000 $14,000 $40,000 $60,000
10
12. Autoimmune diseases
Cancers
Strokes
Heart attacks
Angina
Low energy
Hunger
Kidney failure
Blindness
Obesity Morbidity: Visceral Fat is a Noxious Cytokine Factory
The Marker for Visceral Fat is a Bulging
Waistline
An Elevated Waist to Hips Circumference
Ratio Signals Metabolic Syndrome (WHR)
• Visceral fat is responsible for all the morbidities associated with obesity.
13. EVL® Device Enables a Safer Bariatric Surgical Alternative
Existing Surgical Options
Surgical risks of cutting into the stomach or
bowel, rearranging the body’s alimentary
plumbing or leaving behind a foreign body.
Adverse nutritional consequences and
untoward sequelae compromise life
outcomes.
Patients eventually encounter a weight loss
plateau and gain back lost weight.
Patients require indefinite surgical follow-
up and regular lab testing.
Invasive and expensive.
Endoscopic Visceral Lipectomy (EVL)
Provides the benefits of existing options
with fewer possible surgical complications
and with no lifestyle compromises.
No cutting into the stomach, bowel or
rearranging the alimentary plumbing, or
leaving behind a foreign body.
No adverse nutritional effects or untoward
sequelae
Results expected to be permanent
Procedure may be repeated until ideal
weight is obtained.
Minimally invasive and cost effective.
14. EVL® Directly Removes The Noxious Cytokine Factory
https://youtu.be/5xC8pvNmMeI• If embedded video above fails to play, click on icon or link:
13
15. Projected Development Timeline
QUARTERS FROM COMPLETION OF FUNDING
Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8
Airbrush® II Sell
inventory
Use up direct
materials for final
run
Sell last units
Airbrush® IIE Tweak Beta
Prototype
510(k) Start Production Commence
Sales
Get CE
Airbrush® III Tweak Beta
Prototype
510(k) Start
Production
Commence
Sales
Get CE
Airbrush®
Collectors
Tweak Beta
Prototypes
510(k) Start
Production
Commence
Sales
Get CE
EVL® Tweak Beta
Prototype
Add cautery
510 (K)
without
cautery
Start Production
Tweak Cautery
Commence
Sales Supplemental
510(k) with
cautery
Commence
Sales
Clinicals
abroad
Supplemental
or modified
510(k) for
additional
indication
Promote as
Lap-Band®
Alternative
Get CE
14
16. Sales and Marketing
Management has extensive personal connection with major research hospitals and
surgery centers, respected doctors and Key Opinion Leaders (“KOL’s”).
Placement with podium doctors
Direct marketing to hospitals and doctor training.
White papers and peer-reviewed articles from medical centers.
Promotional budget set at 20% of sales.
Direct trade “rifle barrel” advertising with and internet rich media.
Cooperative advertising with promotional incentives to multiply the effect of
the advertising budget, establish our brand brand and create patient flow
(“pull”).
Domestic: combination of salaried representatives in key cities (LA and NYC)
and independent representatives elsewhere fed leads from trade shows and
advertising.
International: use of distributors.
License and refer patients to branded treatment centers cross-selling bariatric
surgery, liposuction, and adipocyte-derived stem cell autografts.
EVL®
15
17. Key Financial Summary
Prices: Airbrush® II: $50,000, Airbrush® IIE: $50,000, EVL® : $50,000, Airbrush® III: $9,000.
Consumables: Airbrush® II, IIE and III: $100, EVL® liposuction pack: $300, visceral lipectomy pack: $1,700.
Average product margin: 20%, 17%, and 83% respectively.
Product Launch and sales begin in Q4 2018 (Oct. 2018).
2018 unit sales: Airbrush® IIE: 21 domestic, 11 international; Airbrush® III: 25 domestic, 13 international;
EVL®: 6 domestic and 3 international.
EVL® sold initially as an endoscopic subcutaneous lipoaspiration device only until additional indication of
visceral fat removal obtained, forecast for 2018.
Buy/Try conversion ratio: 31%.
International/Domestic unit sales: 50% (2016) growing to 100% (2021).
Annual unit sale growth: 20% with exception of EVL® upon obtaining specific “visceral lipectomy”
modified 510(k) indication at end of 2018 (i.e. between 2018-2019, 30%) and upon obtaining insurance
reimbursement end of 2018 after short term efficacy studies, i.e. 2019-2020, 30%)
Liposuctions or bariatric surgeries/year/surgeon: 24; Consumables/liposuction or EV L®: 1.
Sales commission: 15% and Promotional Incentives (e.g. Cinch It™): 5%; Product Liability: 5%.
“Bottom Up” Conservative Projections FME 5/31/17 1,000‘s
16
2017 2018 2019 2020 2021
SALES $0 $3,017 $16,222 $24,181 $33,880
EBITDA ($1,942) ($270) $1,844 $3,042 $4,547
NET INCOME ($1,978,936) ($318,144) $1,796,303 $2,994,106 $3,042,199
18. Market Size Estimate of Potential Growth (“Top Down”)
Estimated for treating only the obese patients with metabolic syndrome’s most severe
manifestation, diagnosed type 2 diabetes mellitus in the U.S.
U.S. Diabetes Prevalence1
In 2012, 29.1 million Americans, or 9.3% of the population, had diabetes.
Approximately 1.25 million American children and adults have type 1 diabetes.
Undiagnosed: 8.1 million were undiagnosed
19.75M diagnosed, type 2 Diabetics in the U.S.
• Potential Market Size and Net Income
• $1,700 per single procedure consumable x 19.75M diagnosed type 2 U.S Diabetics x 31%
Net Profit = $10.41B Net Income
• 1% Market Penetration = $104M Net Income
• Market Growth1
• 1.4 million Americans are diagnosed with diabetes every year
• 1.4 Million new cases x $1,700 x 31% = $744M yearly target market growth
• Endocrinologists2 are recommending surgical intervention more frequently and earlier
• Surgery is more effective than diet and exercise for long term weight reduction.
1. American Diabetes Association:
http://www.diabetes.org/diabetes-basics/statistics/#sthash.FZsSxxWX.dpuf
2. Endocrine Society: http://www.news-medical.net/news/20140624/Weight-loss-surgery-more-effective-than-
diet-exercise.aspx
17
19. Investment Highlights
Large &
Growing
Market
Persistence Market Research estimates the global bariatric surgery device
(bands, staples, clips, balloons, etc.) market size at $1.4B in 2014 with an
expected CAGR of 9.6% to reach $2.5B by 2020.
McKinsey Global Institute reported world wide expenditures for Obesity-
Related Disease Diseases (diabetes, hypertension, sleep apnea, etc.)
reached $2T in 2014.
Strong
Management
Team
Extensive experience and solid track record of successful execution.
Sound vision and strategy for growth: management has extensive.
connections with key hospitals, industry doctors and opinion makers.
Depth of professional, regulatory and licensing experience.
Sound Growth
Strategy
Subscription revenue base model with add-on products or procedures.
Large potential for branded centers opening: usage of extracted fat as
filler in various plastic procedures and cross selling opportunities.
Worldwide expansion.
Viable Business
Model
Proven concept and strong barriers to entry: third-generation device with
large IP Protection: 3 patents on method and device and numerous more
US pending.
Short time to market: Estimated 12 months to create and test, large OEM
medical device company agreed to develop prototype and manufacture.
Disruptive technology in both applications.
18
20. Contact
BioSculpture Technology, Inc.
Robert L. Cucin M.D., J.D., M.B.A.
CEO
Administrative Office
1701 South Flagler Drive
Suite 607
West Palm Beach, FL 33401
Tel (561) 651-7816
Tel: (212) 977-5400
Fax: (561) 651-7808
rlcucin2
ceo@biosculpturetechology.com
Research & Development Office
Okeechobee Plaza
1550-4 Latham Road
West Palm Beach, FL 33409
Tel: (212) 300-0060
Fax: (212) 400-4234
www.biosculpturetechnology.com www.evl.technology
19