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Mix&Go

TM

– A Universal “Glue”

For Clinical Diagnostics, Life Sciences and Beyond
Australian Microcap Investment Conference
Melbourne, October 23, 2013
Dr. Geoff Cumming, CEO
Anteo Diagnostics Ltd (ASX:ADO)
Forward Looking Statement
The purpose of the presentation is to provide an update of the business of Anteo Diagnostics
(ASX:ADO). These slides have been prepared as a presentation aid only and the information they
contain may require further explanation and/or clarification. Accordingly, these slides and the
information they contain should be read in conjunction with past and future announcements made by
Anteo and should not be relied upon as an independent source of information. Please contact Anteo
and/or refer to the Company's website for further information.
The views expressed in this presentation contain information derived from publicly available
sources that have not been independently verified. No representation or warranty is made as to the
accuracy, completeness or reliability of the information.
Any forward looking statements in this presentation have been prepared on the basis of a
number of assumptions which may prove incorrect and the current intentions, plans, expectations
and beliefs about future events are subject to risks, uncertainties and other factors, many of which
are outside Anteo Diagnostics Ltd’s control. Important factors that could cause actual results to
differ materially from assumptions or expectations expressed or implied in this presentation include
known and unknown risks. Because actual results could differ materially to assumptions made and
Anteo’s current intentions, plans, expectations and beliefs about the future, you are urged to view all
forward looking statements contained in this presentation with caution.
This presentation should not be relied on as a recommendation or forecast by Anteo
Diagnostics Limited. Nothing in this presentation should be construed as either an offer to sell or a
solicitation of an offer to buy or sell shares in any jurisdiction.
Anteo Diagnostics Overview
A Biotech company with

highly experienced Board and Management team

D evelops, manufactures and commercialises proprietary surface coatings for healthcare industry
O ur Mix&GoTM is a novel “glue” with a ubiquitous array of applications
Diagnostics (IVD) and Life Sciences (LS) – here and now
• Launch of commercial Mix&Go products in 2010
• Enables strong yet flexible binding of biomolecules to a broad variety of synthetic
surfaces without causing damage to their structure or activity
• Improves the outcome of pathology tests, such as blood tests
• Commercial agreements with several companies: Bangs, Merck, Affymetrix, One
World Lab, Gennova etc.
• Extensive patents protect technology and applications
• Cash flow positive through 2014
Bioseparations – the next opportunity
• Unique market opportunity to provide cost-effective solution
• Focus on rapidly growing therapeutics market
• Mix&Go makes it practical to replace current cumbersome methods with
magnetic separation – a desirable but so far uneconomical solution
Anteo – Corporate Overview

Business Model

Revenues from product sales
Royalties from license agreements
Paid R&D collaborations with IVD & LS companies

Proven Technology Platform

Proprietary technology licensed to major
international healthcare companies with additional
deals anticipated

Patented Technology

Significant and growing patent portfolio

Clear Development Path

Mix&Go development is progressing from
diagnostics to next market sector: bioseparations
Significant additional opportunities exist

Robust Deal Portfolio

Over 80 companies are actively assessing Mix&Go
in-house or through collaborative work

Sound Commercialisation
Strategy

Combination of licensing, collaborations and product
sale provide diversified portfolio of revenue streams
with clear path to profitability
Recent Highlights
Commercial agreements
02/13
02/13

05/13
06/13
08/13

Partnership agreement with U.S. based One World Lab
Commenced paid feasibility study with global leader in lateral flow
POC test manufacture
Sales partnership agreement with Spanish based Gennova Scientific
for Europe & Latin America
Feasibility agreement with major global healthcare company for
development of a POC device
Commenced further paid studies with lateral flow POC company

Patents
06/13
08/13

Granted European patent
Filed 2 new patent applications

Government Grants
07/13

Received 2-year $1.7m grant from Commercialisation Australia
Company Snapshot
Corporate Snapshot

Board

ASX

ADO

Cash

$3.10M

Market Cap.

$49 M

Dr. Geoff Cumming – Chief Executive Officer

52 week high

7c

Ms. Sandra (Sam) Andersen – Non-Executive Director

52 week low

5c

Shares on issue

770.4m

Shareholders

3,385

Avg. daily volume

1,492,505

Top 20

36%

Directors/staff

17.8%

Mr. Mark Bouris – Non-Executive Chairman

Mr. Richard Martin – Executive Director
Dr. John Hurrell – Non-Executive Director

Executive Team
Dr. Geoff Cumming – Chief Executive Officer
Dr. Joe Maeji – Chief Scientific Officer

Major Shareholders
Shareholder

Ownership

First Cape Mgt Pty Ltd

10.02%

Austcorp 190 Pty Ltd

4.26%

Nimrod Finance Ltd

2.57%

Mr. Richard Martin – Chief Financial Officer

Dr. Tina Baumgartner – VP Business Development &
Marketing
Mix&Go –
A Game Changing Technology
Mix&Go - A Game Changing Technology
Surface coatings are crucial in many industries and serve many purposes, e.g.:
• Provide adhesive properties, i.e. act like a “glue”
• Confer optical properties
• Add magnetic or electrical properties
Mix&Go is a universal “glue” that is uniquely suited for applications in diagnostics
and life sciences:
• Gentle “glue” that maintains the activity of fragile biomolecules
• Improves pathology tests  earlier disease detection
• Reduces cost of test development and manufacture
• Applicable to numerous large healthcare segments:
• Pathology/diagnostic tests
• Point-of-care diagnostics
• Bioseparation
• Drug discovery and development
• Well suited to “glue” in a variety of applications and industries outside of
healthcare, e.g. Resources and Cleantech
Current Focus: Diagnostics and Life Sciences

Laboratory Diagnostics

• Global IVD: $44B (2011)
• Immunoassays: $8.8B
• Drivers: aging population =
more tests, higher Asian
demand, technology innovations

Point-of-care

• $8 B (2011)
• $38B (2017 forecast)
• Drivers: price pressure, lack of
qualified staff , need for
immediate information,
decentralisation, bedside testing

Rapid Test Products

Life Science R&D

• $3.7B in 2012
• Drivers: decentralised testing,
broadening applications, direct
to consumer marketing

• Very large and diverse
• Drivers: price pressure,
efficiency
Mix&Go – The Secret Sauce

3D structure is
damaged

Orientation is
random

Without Mix&Go
Consequences

Proprietary solution:
metal polymers

Undamaged,
oriented

With Mix&Go
Characteristics

Benefits

Vast majority of proteins are nonfunctional

Undamaged, fully functional proteins on
surface

Increased performance
Less non-specific binding
Improved protein stability

Lower sensitivity, LOD, dynamic range

Less protein and/or beads required

Reduced cost
Saves valuable, expensive proteins

More protein needed

Easy and fast to use and manufacture

Improves efficiency
Simpler test procedures
Manufacturing faster, easier, more scalable

Improved reproducibility

Improved accuracy with improved %CV
The Proof Is In The Data
Mix&Go™

Traditional

Improvement

IL4

0.05 pg/mL

0.2 pg/mL

4x

Troponin I

5 pg/mL

50 pg/mL

10x

TNF-α

5 pg/mL

> 250 pg/mL

50x

HBcAg

<10 pg/mL

150 pg/mL

15x

TSH

<0.001 uIU/mL

0.006 uIU/mL

6x

Sensitivity
Sensitivity improvement 4
to 50-fold!

Mix&Go™

Traditional

Capture antibody (CaB)
concentration

0.125 mg/mL

1.0 mg/mL

cAb Cost per Plate*

$1.10

$8.80

Plate Cost*

$0.55

Total Cost

$1.65

Cost
More than 8-fold reduction
in cost of goods sold

$4.92
$13.72

* Cost in AUD$

Stability

Freshly Coated

14 Days @ 37°C

14 Days @ 25°C
20,000

Stability even at high
temperatures - better shelf
life

15,000

10,000
5,000
200 μg/mL

50 μg/mL

10 μg/mL

0
200 μg/mL 50 μg/mL

10 μg/mL

200 μg/mL

50 μg/mL

10 μg/mL
Mix&Go – Better Tests Faster!
Mix&Go can improve all aspects of test development and manufacture so better
tests can be developed faster
Performance Is Key,
e.g. sensitivity, limit of
detection

New Test Possible
for fragile proteins

Fast Development
Increases speed to market

Ease of Manufacture
User-friendly, stable, robust

Less Raw Materials
Improved margins

Scalable
From R&D to manufacturing
without changes in procedure
Bioseparations –
A Significant Market Opportunity
Bioseparation or How to Get a Pure Protein
Bioseparation: isolating rare proteins or cells from a complex mixture without
contamination, e.g. the purification of
• Therapeutic antibodies/biologic drugs
• Vaccines for human and veterinary use
• Rare cells, e.g. stem cells or circulating tumor cells
• Proteins for R&D purposes

Anteo’s Solution: Mix&Go

• Enables preferred magnetic isolation approach which currently is too
expensive
• Easy scale-up from R&D batches to large scale manufacturing batches
• Easy to automate, a critical aspect in large scale manufacturing
Mix&Go can change the way proteins are purified, positively impacting large
industries from biological drug and vaccine manufacturing to stem cell research
Bioseparation – The Opportunity
Current Approach
Chromatography:
• Time consuming
• Expensive
• Hard to automate
• Capacity constraints

Paradigm Shift
With Mix&Go magnetic separation can
become reality
• technically superior solution
• economically advantageous

Alternative
Magnetic separation:
• Technically superior
• Currently unaffordable

Large Opportunity
• Protein and protein drug
manufacturing: $3-5B
• Vaccine manufacturing: $620M in
2015

Leverage Mix&Go in bioseparations to create
significant long-term revenue streams for Anteo
Bioseparations: Why Now?

Internal Drivers

External Drivers

• Proof of concept - Mix&Go
approaches show better
performance than conventional
methods

• Increased importance Biologics/protein drugs play an
ever more important role:7 out of
the top 10 drugs sold in 2012
were biologics

• Improvement - Mix&Go can
generate novel, versatile
approaches for bio-separation

• Patent Application Filed securing a strong IP position
• Opportunity to move up value
chain
• Global network and relationships
developed through Mix&Go that
will fast-track market penetration

• Market need - expressed desire
by users to move to magnetic
separation but unfavorable
economics currently prevent that
move
• Changing needs – an ever
increasing variety of biological
molecules requiring new
approaches
Additional Opportunities
Capitalise on
Diagnostics/POC
Life Science Research
Expand on
Diagnostics/POC
Life Science Research

Capitalise on
Bioseparations
Expand on
Cleantech,Resources
Drug screening

Develop Bioseparations

Capitalise on
Diagnostics/POC
Life Science Research

Initiate Bioseparations

Diagnostics/POC
Life Science Research

Expand on
Bioseparations
Explore
Cleantech,Resources
Drug screening
Targets and Timeline
• Agreement with top-tier
POC company
• 2-3 agreements with LS
companies

• Agreement w/ top tier IVD
• Agreement(s) w/ mid-tier IVD
• Agreement(s) w/ POC company
• Deal(s) w/ LS companies

• Agreement with top-tier
POC company
• Agreement with mid-size
IVD

• Additional deals in IVD, POC
and LS
• Agreements in bioseparations,
resources, cleantech, other
Keypoints
• Mix&Go is a proprietary platform technology with broad applicability in
diagnostics, life sciences, bioseparations and beyond
• Mix&Go is proven licensed and gaining significant traction in commercial
markets
• Mix&Go success means Anteo is becoming cash flow positive
• Focus on diagnostics and life sciences with expansion into
bioseparations provides Anteo significant revenue opportunities
• Strong leadership - Board and management team in place to drive
growth
• Global team resources and network to capitalise on growth opportunity
Anteo’s Mix&Go is an enabling technology beneficial to many industries and
applications. Mix&Go is quickly gaining traction in the diagnostic and life sciences
industries and has significant mid-term potential in bioseparations and long term in
a large number of applications in health care and other industries.
Contact Information
Thank you very much for your interest in Anteo Diagnostics
For more information please contact:

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Anteo Diagnostics Microcap Presentation October 2013

  • 1. Mix&Go TM – A Universal “Glue” For Clinical Diagnostics, Life Sciences and Beyond Australian Microcap Investment Conference Melbourne, October 23, 2013 Dr. Geoff Cumming, CEO Anteo Diagnostics Ltd (ASX:ADO)
  • 2. Forward Looking Statement The purpose of the presentation is to provide an update of the business of Anteo Diagnostics (ASX:ADO). These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or clarification. Accordingly, these slides and the information they contain should be read in conjunction with past and future announcements made by Anteo and should not be relied upon as an independent source of information. Please contact Anteo and/or refer to the Company's website for further information. The views expressed in this presentation contain information derived from publicly available sources that have not been independently verified. No representation or warranty is made as to the accuracy, completeness or reliability of the information. Any forward looking statements in this presentation have been prepared on the basis of a number of assumptions which may prove incorrect and the current intentions, plans, expectations and beliefs about future events are subject to risks, uncertainties and other factors, many of which are outside Anteo Diagnostics Ltd’s control. Important factors that could cause actual results to differ materially from assumptions or expectations expressed or implied in this presentation include known and unknown risks. Because actual results could differ materially to assumptions made and Anteo’s current intentions, plans, expectations and beliefs about the future, you are urged to view all forward looking statements contained in this presentation with caution. This presentation should not be relied on as a recommendation or forecast by Anteo Diagnostics Limited. Nothing in this presentation should be construed as either an offer to sell or a solicitation of an offer to buy or sell shares in any jurisdiction.
  • 3. Anteo Diagnostics Overview A Biotech company with highly experienced Board and Management team D evelops, manufactures and commercialises proprietary surface coatings for healthcare industry O ur Mix&GoTM is a novel “glue” with a ubiquitous array of applications Diagnostics (IVD) and Life Sciences (LS) – here and now • Launch of commercial Mix&Go products in 2010 • Enables strong yet flexible binding of biomolecules to a broad variety of synthetic surfaces without causing damage to their structure or activity • Improves the outcome of pathology tests, such as blood tests • Commercial agreements with several companies: Bangs, Merck, Affymetrix, One World Lab, Gennova etc. • Extensive patents protect technology and applications • Cash flow positive through 2014 Bioseparations – the next opportunity • Unique market opportunity to provide cost-effective solution • Focus on rapidly growing therapeutics market • Mix&Go makes it practical to replace current cumbersome methods with magnetic separation – a desirable but so far uneconomical solution
  • 4. Anteo – Corporate Overview Business Model Revenues from product sales Royalties from license agreements Paid R&D collaborations with IVD & LS companies Proven Technology Platform Proprietary technology licensed to major international healthcare companies with additional deals anticipated Patented Technology Significant and growing patent portfolio Clear Development Path Mix&Go development is progressing from diagnostics to next market sector: bioseparations Significant additional opportunities exist Robust Deal Portfolio Over 80 companies are actively assessing Mix&Go in-house or through collaborative work Sound Commercialisation Strategy Combination of licensing, collaborations and product sale provide diversified portfolio of revenue streams with clear path to profitability
  • 5. Recent Highlights Commercial agreements 02/13 02/13 05/13 06/13 08/13 Partnership agreement with U.S. based One World Lab Commenced paid feasibility study with global leader in lateral flow POC test manufacture Sales partnership agreement with Spanish based Gennova Scientific for Europe & Latin America Feasibility agreement with major global healthcare company for development of a POC device Commenced further paid studies with lateral flow POC company Patents 06/13 08/13 Granted European patent Filed 2 new patent applications Government Grants 07/13 Received 2-year $1.7m grant from Commercialisation Australia
  • 6. Company Snapshot Corporate Snapshot Board ASX ADO Cash $3.10M Market Cap. $49 M Dr. Geoff Cumming – Chief Executive Officer 52 week high 7c Ms. Sandra (Sam) Andersen – Non-Executive Director 52 week low 5c Shares on issue 770.4m Shareholders 3,385 Avg. daily volume 1,492,505 Top 20 36% Directors/staff 17.8% Mr. Mark Bouris – Non-Executive Chairman Mr. Richard Martin – Executive Director Dr. John Hurrell – Non-Executive Director Executive Team Dr. Geoff Cumming – Chief Executive Officer Dr. Joe Maeji – Chief Scientific Officer Major Shareholders Shareholder Ownership First Cape Mgt Pty Ltd 10.02% Austcorp 190 Pty Ltd 4.26% Nimrod Finance Ltd 2.57% Mr. Richard Martin – Chief Financial Officer Dr. Tina Baumgartner – VP Business Development & Marketing
  • 7. Mix&Go – A Game Changing Technology
  • 8. Mix&Go - A Game Changing Technology Surface coatings are crucial in many industries and serve many purposes, e.g.: • Provide adhesive properties, i.e. act like a “glue” • Confer optical properties • Add magnetic or electrical properties Mix&Go is a universal “glue” that is uniquely suited for applications in diagnostics and life sciences: • Gentle “glue” that maintains the activity of fragile biomolecules • Improves pathology tests  earlier disease detection • Reduces cost of test development and manufacture • Applicable to numerous large healthcare segments: • Pathology/diagnostic tests • Point-of-care diagnostics • Bioseparation • Drug discovery and development • Well suited to “glue” in a variety of applications and industries outside of healthcare, e.g. Resources and Cleantech
  • 9. Current Focus: Diagnostics and Life Sciences Laboratory Diagnostics • Global IVD: $44B (2011) • Immunoassays: $8.8B • Drivers: aging population = more tests, higher Asian demand, technology innovations Point-of-care • $8 B (2011) • $38B (2017 forecast) • Drivers: price pressure, lack of qualified staff , need for immediate information, decentralisation, bedside testing Rapid Test Products Life Science R&D • $3.7B in 2012 • Drivers: decentralised testing, broadening applications, direct to consumer marketing • Very large and diverse • Drivers: price pressure, efficiency
  • 10. Mix&Go – The Secret Sauce 3D structure is damaged Orientation is random Without Mix&Go Consequences Proprietary solution: metal polymers Undamaged, oriented With Mix&Go Characteristics Benefits Vast majority of proteins are nonfunctional Undamaged, fully functional proteins on surface Increased performance Less non-specific binding Improved protein stability Lower sensitivity, LOD, dynamic range Less protein and/or beads required Reduced cost Saves valuable, expensive proteins More protein needed Easy and fast to use and manufacture Improves efficiency Simpler test procedures Manufacturing faster, easier, more scalable Improved reproducibility Improved accuracy with improved %CV
  • 11. The Proof Is In The Data Mix&Go™ Traditional Improvement IL4 0.05 pg/mL 0.2 pg/mL 4x Troponin I 5 pg/mL 50 pg/mL 10x TNF-α 5 pg/mL > 250 pg/mL 50x HBcAg <10 pg/mL 150 pg/mL 15x TSH <0.001 uIU/mL 0.006 uIU/mL 6x Sensitivity Sensitivity improvement 4 to 50-fold! Mix&Go™ Traditional Capture antibody (CaB) concentration 0.125 mg/mL 1.0 mg/mL cAb Cost per Plate* $1.10 $8.80 Plate Cost* $0.55 Total Cost $1.65 Cost More than 8-fold reduction in cost of goods sold $4.92 $13.72 * Cost in AUD$ Stability Freshly Coated 14 Days @ 37°C 14 Days @ 25°C 20,000 Stability even at high temperatures - better shelf life 15,000 10,000 5,000 200 μg/mL 50 μg/mL 10 μg/mL 0 200 μg/mL 50 μg/mL 10 μg/mL 200 μg/mL 50 μg/mL 10 μg/mL
  • 12. Mix&Go – Better Tests Faster! Mix&Go can improve all aspects of test development and manufacture so better tests can be developed faster Performance Is Key, e.g. sensitivity, limit of detection New Test Possible for fragile proteins Fast Development Increases speed to market Ease of Manufacture User-friendly, stable, robust Less Raw Materials Improved margins Scalable From R&D to manufacturing without changes in procedure
  • 13. Bioseparations – A Significant Market Opportunity
  • 14. Bioseparation or How to Get a Pure Protein Bioseparation: isolating rare proteins or cells from a complex mixture without contamination, e.g. the purification of • Therapeutic antibodies/biologic drugs • Vaccines for human and veterinary use • Rare cells, e.g. stem cells or circulating tumor cells • Proteins for R&D purposes Anteo’s Solution: Mix&Go • Enables preferred magnetic isolation approach which currently is too expensive • Easy scale-up from R&D batches to large scale manufacturing batches • Easy to automate, a critical aspect in large scale manufacturing Mix&Go can change the way proteins are purified, positively impacting large industries from biological drug and vaccine manufacturing to stem cell research
  • 15. Bioseparation – The Opportunity Current Approach Chromatography: • Time consuming • Expensive • Hard to automate • Capacity constraints Paradigm Shift With Mix&Go magnetic separation can become reality • technically superior solution • economically advantageous Alternative Magnetic separation: • Technically superior • Currently unaffordable Large Opportunity • Protein and protein drug manufacturing: $3-5B • Vaccine manufacturing: $620M in 2015 Leverage Mix&Go in bioseparations to create significant long-term revenue streams for Anteo
  • 16. Bioseparations: Why Now? Internal Drivers External Drivers • Proof of concept - Mix&Go approaches show better performance than conventional methods • Increased importance Biologics/protein drugs play an ever more important role:7 out of the top 10 drugs sold in 2012 were biologics • Improvement - Mix&Go can generate novel, versatile approaches for bio-separation • Patent Application Filed securing a strong IP position • Opportunity to move up value chain • Global network and relationships developed through Mix&Go that will fast-track market penetration • Market need - expressed desire by users to move to magnetic separation but unfavorable economics currently prevent that move • Changing needs – an ever increasing variety of biological molecules requiring new approaches
  • 17. Additional Opportunities Capitalise on Diagnostics/POC Life Science Research Expand on Diagnostics/POC Life Science Research Capitalise on Bioseparations Expand on Cleantech,Resources Drug screening Develop Bioseparations Capitalise on Diagnostics/POC Life Science Research Initiate Bioseparations Diagnostics/POC Life Science Research Expand on Bioseparations Explore Cleantech,Resources Drug screening
  • 18. Targets and Timeline • Agreement with top-tier POC company • 2-3 agreements with LS companies • Agreement w/ top tier IVD • Agreement(s) w/ mid-tier IVD • Agreement(s) w/ POC company • Deal(s) w/ LS companies • Agreement with top-tier POC company • Agreement with mid-size IVD • Additional deals in IVD, POC and LS • Agreements in bioseparations, resources, cleantech, other
  • 19. Keypoints • Mix&Go is a proprietary platform technology with broad applicability in diagnostics, life sciences, bioseparations and beyond • Mix&Go is proven licensed and gaining significant traction in commercial markets • Mix&Go success means Anteo is becoming cash flow positive • Focus on diagnostics and life sciences with expansion into bioseparations provides Anteo significant revenue opportunities • Strong leadership - Board and management team in place to drive growth • Global team resources and network to capitalise on growth opportunity Anteo’s Mix&Go is an enabling technology beneficial to many industries and applications. Mix&Go is quickly gaining traction in the diagnostic and life sciences industries and has significant mid-term potential in bioseparations and long term in a large number of applications in health care and other industries.
  • 20. Contact Information Thank you very much for your interest in Anteo Diagnostics For more information please contact: