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Back up Hipoalbuminemia.pptx
- 4. Factors influencing albumin synthesis: Chen, C.B., Hammo, B., Barry, J. et al. Overview of Albumin Physiology and its Role in Pediatric Diseases. Curr Gastroenterol Rep 23, 11 (2021). https://doi.org/10.1007/s11894-021-00813-6 Chien, SC., Chen, CY., Lin, CF. et al. Critical appraisal of the role of serum albumin in cardiovascular disease. Biomark Res 5, 31 (2017). https://doi.org/10.1186/s40364-017-0111-x
- 6. Albumin is synthesized by hepatocytes released into intravascular space (30%-40%) The remaining native albumin goes to the interstitial space trough the capillary (transcapillary escape rate) Albumin returns back to systemic circulation by way of the lymphatic system it is taken up by many cell types by endocytosis such as endothelial cells Albumin can either be catabolized through lysosomal degradation or released to the extracellular space. Albumin Synthesis, Distribution, and Metabolism
- 7. Chen, C.B., Hammo, B., Barry, J. et al. Overview of Albumin Physiology and its Role in Pediatric Diseases. Curr Gastroenterol Rep 23, 11 (2021). https://doi.org/10.1007/s11894-021-00813-6
Editor's Notes
- Albumin synthesis, distribution, and metabolism. Albumin is synthesized exclusively in the liver by hepatocytes and released into the intravascular space. From the whole-body albumin pool 30%-40% stays in the vascular compartment. The remaining native albumin goes to the interstitial space trough the capillary (transcapillary escape rate). Depending on the tissue involved, the mechanism to escape from circulation may be different: by way of sinusoids (liver, bone marrow), fenestrated endothelia (pancreas, adrenal gland), or via transcitosis. Albumin returns back to systemic circulation by way of the lymphatic system. Although albumin is known as an extracellular molecule, it is taken up by many cell types by endocytosis such as endothelial cells. After endocytosis, albumin can either be catabolized through lysosomal degradation or released to the extracellular space.1
- Albumin synthesis begins in the nucleus, where genes are transcribed into messenger ribonucleic acid (mRNA). The mRNA is secreted into the cytoplasm, where it is bound to ribosomes, forming polysomes that synthesize preproalbumin. Preproalbumin is an albumin molecule with a 24 amino acid extension at the N terminus.