This document discusses the differences between meditation and Total Stress Management (TSM). It provides instructions for different meditation techniques but warns that people are often selling and buying meditation for petty reasons like stress management. TSM involves understanding the root causes of stress, treating them holistically through intellectual efforts rather than temporary emotional relief from activities like meditation. TSM also aims for the welfare of all through sound solutions, not just individuals. It promotes harmony through perspective, intelligence and global welfare.
My series on the piano and piano music continues with the second part of the slideshow on Beethoven.
Sixth of ten presentations on the piano and classical composers.
He didn't write piano music but I had to do a slideshow on the Waltz King and his Beautiful Blue Danube Waltz.
Tenth of ten presentations on the piano and classical musicians. And more to come!
My series on the piano and piano music continues with the second part of the slideshow on Beethoven.
Sixth of ten presentations on the piano and classical composers.
He didn't write piano music but I had to do a slideshow on the Waltz King and his Beautiful Blue Danube Waltz.
Tenth of ten presentations on the piano and classical musicians. And more to come!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. “Lie down in the open on your terrace.
Focus your mind on the blue and clear
sky. Gradually the sky would enter in
you. You would have transcended mind.”
“Sit in lotus position. Let the atmosphere
in your room be free of insects, free of
dust, free of noise and free of other
distractions. You may light an incense
stick. You can have a photo or painting of
your Guru or a deity who elevates your
mood or inspires you. Then begin by
breathing slowly and observe your
breathing.”
“Sit in a lotus posture. Breathe slowly.
Focus your mind on a spot at your navel”
4. “Observe a round spot on a plane
background of the wall. Sit quietly. Let
the thoughts flow.”
The instructions vary according to the
different traditions! What is this all
about? The readers would have easily
gathered that these are the instructions
for different
‘meditation’ techniques. Everyone is
selling and buying so called ‘meditation’
in the petty and vain hope of stress
management! Hence; Beware of
“Meditation!”
What is the difference between
“meditation” and TSM? Why are
“mediation” or relaxation techniques in
great demand than TSM?
5. 1] TSM (Total Stress Management)
constitutes understanding the concept of
STRESS, going to its root causes and then
treating them in a holistic manner, as
completely as possible! This requires
active intellectual efforts by the
participants. Active intellectual
participation makes it more
difficult and less popular as compared to
relaxation programs in some form of
meditation,
pranayama, devotion, some arbitrary tips
in the management books etc. where
temporary emotional solace comes easily.
2] TSM constitutes efforts towards
simultaneous welfare of one and all and
not merely individual welfare. This
requires broadening of perspective. We
6. can call this paradigm shift. This also
makes it more difficult and less popular
because everyone is already preoccupied
and hard pressed with personal problems
of one kind or the other. Coming out of
one’s own “individual and
petty universe” is a burden for most of us,
because we fail to understand how
welfare of others would contribute to our
welfare!
3] Most of us are not aware of the concept
of STRESS. The STRESS is equated with
tension, anxiety, worry, sleeplessness,
irritability, depression, frustration etc.
Actually this is only a small and conscious
part of STRESS. STRESS is universal.
Every living being has STRESS. STRESS
is actually conscious and also
unconscious. Unconscious STRESS forms
7. a major part and is not perceived! This
leaves most of us to falsely believe that we
do not have STRESS!
4]TSM teaches that perspective, policies,
planning, execution of sound intellectual
solutions to personal and social problems
can not be substituted by un-intellectual
emotional games such as so called
meditation and so called devotion and so
called charity. It teaches that
real meditation, real devotion and real
charity are impossible in absence of
intellectual
efforts to rectify social homeostasis!
Most of us feel that it is impossible to
solve social problems and hence fail to do
our own bit in this direction.
8. Most of us have yet to appreciate that;
giving parties, donations, gifts and doing
charity in other forms though not
objectionable, can at best satisfy our ego.
Even though, there is nothing wrong in
such emotional gratification, it can not
help you to manage stress effectively!
Acquiring and spreading wisdom; so as
to solve individual and social problems;
is unique in satisfying your conscience,
i.e. your true self, but it is not easy!
5] The concept of TSM is relatively new.
The people from media, politics, religion
and other fields are not aware of TSM. It
is also true that due to the frenzy of
material success; they do not feel the
thirst of their innate self [soul] and hence
9. may not care to learn about TSM. It is
strange but true that people in scarcity
[due to frustration] and people in
abundance [due to delirious
obliviousness] are not able to quickly
grasp TSM and practice it.
6] TSM aims at harmony between
perspective, intelligence, emotions,
instincts and body; and aims at best
efforts of global welfare through laws,
rules, conventions and so on.
7] TSM firmly upholds individual
freedom to achieve total well being and
suggests us to acquire and practice such
freedom!
8] The conceptualization of TSM was
indeed a slow process. It was quite some
10. time before sufficient conviction was
developed in the accuracy and
appropriateness of TSM. This was
because TSM was not a part of already
existing tradition. It did not receive
practical support from any atheist [non-
believers] or theist [God-believers]
tradition. The
conviction had to result from one’s own
understanding and experiences.
9] The process of developing conviction
was delayed partly because of
demoralization
resulting from non acceptance by the
traditions and also their opponents!
10] Relative delay in acceptance and
publication of books due to various other
reasons! The delay in the work was
11. sometimes [though erroneously]
interpreted as God’s wish!
11] Sometimes there was apprehension
[whether justified or otherwise] of the
possibility
of being misunderstood and sabotaged.
12] Sometimes there was dominance of
asceticism and to some extent frustration
that led to inaction or non-assertion.
Sometimes this led to escapism of one sort
or the other.
13] There was many times a feeling of
uncertainty of life leading to sense of
urgency of TSM and SUPERLIVING
mission. This urgency was subjective and
obviously not shared in action; by most
12. individuals and hence the delay in the
work was further enhanced.
14] Dictatorial attitude and nurturing of
vested interests was scrupulously avoided.
It is known that most of the times the
work gets going faster because of fear or
because of
vested interest. Since both of these lacked,
mission superliving and TSM was further
delayed.
15] Lack of apparent glamour and glitter
of superficiality and pettiness. The
excitement associated with glamour and
glitter is missing in mission superliving
and TSM for an immature individual.
Hence it did not pick the fancy of even
talented individuals.
13. 16] Some of the books on TSM are
comparatively less lucid and little more
tedious. This is so because the emphasis is
given on accuracy rather than literary
qualities.
17] Everything has its own time. When
the social psyche gets ready for digesting
certain concepts (oneness of spiritualism
and materialism); they spread like wild
fire and become vogue of the day.
18] It is also possible that there are still
some inaccuracies and or deficiencies left
in TSM, which is why it is not as popular
as one would have liked it to be.
19] The personal deficiencies of the
propounder may also account for
14. inadequate spread and influence of the
TSM.
20] Inertia of the sympathizers resulting
from various reasons on the one hand and
lack of finesse and irritability of those
involved; due to urgency and impatience
on the other; probably made the progress
tardy and checkered.
21] Most importantly, the
NAMASMARAN i.e. being connected
with God has somewhere been deficient!
Let us all try to study, refine and enrich,
practice (making use of all possible
modalities; and most importantly
NAMASMARAN) and share TSM (Total
Stress Management), superliving, holistic
health; SUPERJOYOUSLY; as a
15. SUPER-TRANSACTION, in a non-
mercenary, non-commercial and non-
charity manner!
Dr. Shriniwas
Kashalikar