The document covers the autonomic nervous system, detailing the differences between the sympathetic (adrenergic) and parasympathetic (cholinergic) systems, as well as the functions of various adrenergic and anti-adrenergic drugs. It explains the role of the nervous system in regulating bodily functions and the synthesis of neurotransmitters like adrenaline from tyrosine. Additionally, it discusses several adrenergic drugs and their applications in medical treatments such as hypertension and erectile dysfunction.

1. NAME : Ashish Rambhau Gadage
(F Y M Pharm Cology)
Topic Name:- AUTONOMIC NERVOUS SYSTEM

2. AUTONOMIC NERVOUS SYSTEM
(Adrenergic & Anti Adrenergic drug)
CONTENT :-
Introduction of Nervous system
Basic of Nerve
Difference of Sympathetic(Adrenergic) & Parasympathetic System(Cholinergic)
Adrenergic system (How make Adrenaline & Non Adrenaline in Axon)
Adrenergic Receptor with their Location
Sympathomimetic drug ( Adrenergic drug )
Sympatholytic drug (Anti Adrenergic drug)

3. Introduction of Nervous system

4. Basic of Nerve
Spinal Nerve :-
Originated from the Spinal Cord & Connect to the Periphery known as Spinal
Nerve.
There are 31 pairs are present in PNS
Cervical -8 pairs
Thoracic - 12 pairs
Lumber - 05 pairs
Sacral - 05 Pairs
Cocayx - 01 pairs

5. Cranial Nerve:-
Originated from
the Brain & Connect
to the Periphery
known as Cranial
Nerve.
There are 12 pairs
are present in PNS

6. DRUGS ACTING ON AUTONOMIC NERVOUS
• Nervous system is your body's command center.
• Originating from your brain, it controls your movements, thoughts and
automatic responses to the world around you.
• Autonomic nervous system (ANS) regulates physiologic processes, such
as bloodpressure, heart rate, body temperature, digestion, metabolism,
fluid and electrolyte balance, sweating, urination, defecation, sexual
response and other processes.

7. • Autonomic nervous system (ANS) is involuntary in
nature and the activity of this system is maintained
automatically.
• In parasympathetic preganglionic fibers are very long
and postganglionic fibers are very short ,
• In sympathetic system, the preganglionic fibers are
short and postganglionic fibers are very long.

8. DIFFERENCE SITES & ACTION
SYMPATHETIC & PARASYMPATHETIC
SYSTEM

9. NEUROTRANSMETER IN ANS
ANS Preganglionic Postganglionic
Sympathatic Acetylcholine Epinephrine
Para Sympathatic Acetylcholine Acetylcholine

10. Adrenergic system
(How make Adrenaline & Non Adrenaline in Axon)
• Process :-
 Tyrosine is converted into DOPA in the presence of Tyrosine Hydroxylase (rate
limiting step in synthesis of Noradrenaline
 Catecholamine's are derived from amino acid tyrosine, which is derived from
dietary sources as well as synthesis from phenylalanine.
 Adrenaline are DOC in Anaphylactic shock.
Dopamine - DOC in Cardiogenic shock
Adrenergic receptors are membrane bound G-protein coupled receptors.

12. Adrenergic Receptor with their Location

13. IMPORTANCE ACTION
IMPORTANCE ACTION OF Adr, NA & ISOPRENALINE
ADRENALINE @1,@2,B1,B2,And Weak B3 action
NON ADRENALINE @1,@2,B1,B3,but no B2 action
ISOPRENALINE B1,B2,B3,but no @2action

14. Adrenergic Drug (Sympathomimetic drug )

16. ANTIADRENERGIC SYSTEM
( SYMPATHOLYTIC DRUG )
• Antiadrenergic drug which antagonize the receptor action of
adrenaline and related drugs.
• These drugs act by blocking a and/or ẞ-adrenergic receptors.
• Phentolamine is treatment of erectile dysfunction, withdrawal
hypertension with clonidine and methyldopa, cheese reaction.

17. • Tolazoline is vasodilation used in angiography of peripheral blood
vessel.
• Phenoxybenzamine is used for treatment of hypertension episode
seen with pheochromocytoma.
• Prazosin, terazosin and doxazocin DOC for hypertension
associated with dyslipidemia and hypertension associated with
BPH

19. Classification Of B Blocker