Exposure to air pollution near a steel plant was associated with reduced heart rate variability according to a randomized crossover study. Sixty participants spent time at either a location near a steel plant (Bayview site) or a college campus farther from the plant (College site). Compared to the College site, several measures of heart rate variability were significantly lower at the Bayview site, including a 13% reduction in one time domain measure and a 15% reduction in one frequency domain measure. Air pollution levels were also slightly but significantly higher at the Bayview site. Increases in individual air pollutants, including carbon monoxide, nitrogen oxides, sulfur dioxide, and particulate matter, were associated with reductions in various heart rate variability measures.
Airborne Particulate Matter And Human Health:Perspective And Case Study-Garg ...ECRD IN
This document summarizes research on the health effects of airborne particulate matter. It discusses epidemiological studies that have found associations between particulate exposure and increased mortality and morbidity. Specifically, exposures to PM10 and PM2.5 have been linked to increased hospital admissions and decreased lung function. The document also reviews the gaps in understanding these health impacts in India, noting that more research is needed that focuses specifically on PM10 and PM2.5, as most Indian data so far has examined total suspended particulates only. It calls for efforts to better understand the epidemiology, toxicology and exposure levels related to particulate air pollution in India.
This is basically a protocol upon the basis of P.G Public Health presentation on behalf of the Health effects due to environmental pollution on population.
A presentation made at the 2015 NC BREATHE Conference by Jason West, PhD of University of North Carolina - Chapel Hill. Sponsored by Clean Air Carolina and partners, the 2015 NC BREATHE Conference was held on March 27, 2015 in Raleigh, NC to bring together air quality researchers, medical and public health professionals, and policymakers to share the latest research on the health impacts of air pollution, the positive health outcomes related to clean air policy-making, and the resulting economic benefits.
Ambient air pollution_and_population_hea (1)cpinchel
The document summarizes research presented at a 2003 conference on air pollution and human health. It discusses studies on:
1) Exposure assessment that examined variations in particle concentrations and compositions across locations and time periods. Studies found higher ultrafine particle levels in winter and near traffic.
2) Toxicology research demonstrating adverse health effects from air pollution exposure, including increased biomarkers of lung and heart damage. Studies also found evidence of genotoxic and mutagenic effects.
3) Epidemiology research further supporting associations between air pollution exposure and negative health impacts like hospitalizations. Studies improved methods for estimating exposures near traffic sources.
1) Dead space refers to the volume of each breath that is inhaled but does not participate in gas exchange. There are different types of dead space including anatomic, alveolar, physiologic, and equipment dead space.
2) The term dead space is used inconsistently in clinical settings and literature due to different measurement methods and factors like intubation and ventilation methods.
3) Standardized terminology under existing standards organizations is suggested to reduce confusion and improve interpretation of dead space values reported in literature.
This study analyzed Medicare hospital admission records in Cook County, Illinois between 1985-1994 to examine whether preexisting medical conditions increase a person's risk of adverse health effects from airborne particulate matter (PM10). The researchers found:
1) Hospital admissions for cardiovascular diseases increased almost doubled in subjects with concurrent respiratory infections when PM10 levels rose.
2) Risk of PM10-associated admissions for chronic obstructive pulmonary disease (COPD) and pneumonia increased for those with a previous admission history of conduction disorders or cardiac dysrhythmias.
3) People with asthma had twice the risk of a PM10-associated pneumonia admission and those with heart failure had twice the risk of PM10-induced COPD admissions
External Cost of Electricity Generation Systems (2)SSA KPI
AACIMP 2010 Summer School lecture by Yoshio Matsuki. "Sustainable Development" stream. "External Cost of Electricity Generation Systems" course. Part 2.
More info at http://summerschool.ssa.org.ua
Airborne Particulate Matter And Human Health:Perspective And Case Study-Garg ...ECRD IN
This document summarizes research on the health effects of airborne particulate matter. It discusses epidemiological studies that have found associations between particulate exposure and increased mortality and morbidity. Specifically, exposures to PM10 and PM2.5 have been linked to increased hospital admissions and decreased lung function. The document also reviews the gaps in understanding these health impacts in India, noting that more research is needed that focuses specifically on PM10 and PM2.5, as most Indian data so far has examined total suspended particulates only. It calls for efforts to better understand the epidemiology, toxicology and exposure levels related to particulate air pollution in India.
This is basically a protocol upon the basis of P.G Public Health presentation on behalf of the Health effects due to environmental pollution on population.
A presentation made at the 2015 NC BREATHE Conference by Jason West, PhD of University of North Carolina - Chapel Hill. Sponsored by Clean Air Carolina and partners, the 2015 NC BREATHE Conference was held on March 27, 2015 in Raleigh, NC to bring together air quality researchers, medical and public health professionals, and policymakers to share the latest research on the health impacts of air pollution, the positive health outcomes related to clean air policy-making, and the resulting economic benefits.
Ambient air pollution_and_population_hea (1)cpinchel
The document summarizes research presented at a 2003 conference on air pollution and human health. It discusses studies on:
1) Exposure assessment that examined variations in particle concentrations and compositions across locations and time periods. Studies found higher ultrafine particle levels in winter and near traffic.
2) Toxicology research demonstrating adverse health effects from air pollution exposure, including increased biomarkers of lung and heart damage. Studies also found evidence of genotoxic and mutagenic effects.
3) Epidemiology research further supporting associations between air pollution exposure and negative health impacts like hospitalizations. Studies improved methods for estimating exposures near traffic sources.
1) Dead space refers to the volume of each breath that is inhaled but does not participate in gas exchange. There are different types of dead space including anatomic, alveolar, physiologic, and equipment dead space.
2) The term dead space is used inconsistently in clinical settings and literature due to different measurement methods and factors like intubation and ventilation methods.
3) Standardized terminology under existing standards organizations is suggested to reduce confusion and improve interpretation of dead space values reported in literature.
This study analyzed Medicare hospital admission records in Cook County, Illinois between 1985-1994 to examine whether preexisting medical conditions increase a person's risk of adverse health effects from airborne particulate matter (PM10). The researchers found:
1) Hospital admissions for cardiovascular diseases increased almost doubled in subjects with concurrent respiratory infections when PM10 levels rose.
2) Risk of PM10-associated admissions for chronic obstructive pulmonary disease (COPD) and pneumonia increased for those with a previous admission history of conduction disorders or cardiac dysrhythmias.
3) People with asthma had twice the risk of a PM10-associated pneumonia admission and those with heart failure had twice the risk of PM10-induced COPD admissions
External Cost of Electricity Generation Systems (2)SSA KPI
AACIMP 2010 Summer School lecture by Yoshio Matsuki. "Sustainable Development" stream. "External Cost of Electricity Generation Systems" course. Part 2.
More info at http://summerschool.ssa.org.ua
Study: Perinatal Outcomes and Unconventional Natural Gas Operations in Southw...Marcellus Drilling News
This study investigated the association between proximity to unconventional natural gas operations (UGD) in Pennsylvania and perinatal outcomes using birth records from 2007-2010. Mothers were categorized into exposure groups based on the number and distance of gas wells within 10 miles of their residence. After adjusting for confounding factors, the highest exposure group had slightly lower average birth weights and a higher rate of babies born small for gestational age compared to the lowest exposure group, though clinical significance is unclear. Larger longitudinal studies are needed to better evaluate potential health impacts of UGD.
The document describes an epidermal device that can noninvasively map blood flow both macrovascularly and microvascularly in a precise and continuous manner. The device uses an array of thin thermal actuators and sensors that intimately conform to the skin to monitor subsurface blood flow. Experimental studies on humans validate that the device can accurately measure directional blood flow in large veins under various physiological conditions as well as changes in microvascular flow from actions like deep breathing. Quantitative models are used to convert the thermal measurements into estimates of blood flow rates. The low-profile, soft design allows for potential long-term monitoring during daily activities.
This service provides free independent abstracts of medical publications. The abstracts are reviewed by the IPCRG research team to ensure relevance and accuracy. The abstracts summarize the main ideas but do not constitute treatment recommendations. Feedback on the abstracts is welcome.
The document describes an ultrathin, soft, skin-conforming sensor technology that can noninvasively and precisely map both macrovascular and microvascular blood flow. The sensor consists of an array of thin metallic thermal actuators and sensors that conform intimately to the skin through van der Waals forces. Experimental studies on human subjects demonstrate the sensor's ability to sensitively and accurately measure directional blood flow in large subsurface vessels and changes in near-surface microvascular flow induced by breathing and skin stimulation. An advanced pulsed operation mode offers potential for long-term continuous monitoring by reducing drift and power consumption.
NRDC claims that power plant emissions cause 30,000 premature deaths annually from fine particulate matter and ozone. However, the paper finds these claims are implausible. Sulfate, the main component of particulate matter from power plants, is not toxic. Additionally, regulatory costs intended to reduce emissions ultimately cause harm to public health by reducing incomes and ability to invest in health and safety. The large costs of proposals like the Clean Power Act are unlikely to provide significant health benefits.
1. The study analyzed the association between air pollution (PM2.5 and O3) and mortality in Los Angeles using a cohort from the American Cancer Society and controlling for individual and neighborhood factors.
2. It found that all-cause mortality was associated with higher PM2.5 levels, with a relative risk of 1.17 for each 10 μg/m3 increase in PM2.5. Risks were higher for deaths from ischemic heart disease and lung cancer.
3. The results provide evidence that intra-city variations in air pollution exposure lead to stronger health effects than prior studies using average exposures across cities, suggesting localized pollution drives additional health impacts.
Physico-Chemical Analysis of Selected Groundwater Samples of Inkollu Mandal, ...IJERA Editor
Physico-chemical parameters of groundwater quality based on Physic-chemical parameters at Inkollu mandal, Prakasam district, Andhra Pradesh, India have been taken up to evaluate its suitability for Drinking purpose. Nine ground water samples were collected from different places of Inkollu mandal of Prakasam district. The quality analysis has been made through the pH, EC, TDS, Total Hardness, Sodium, Potassium, Calcium, Magnesium, Chloride, Sulphate, Nitrate, Fluoride and Iron. By observing the results, it was shown that the parameters from the water samples were compared with WHO (World Health Organization) and BIS (Bureau of Indian Standards), USPH (United state Public health ) for ground water .The results revealed that some parameters were in high concentration and quality of the potable water has deteriorated to a large extent at some sampling locations.
This study estimated community exposure and health risks from sulfur dioxide (SO2) emissions from three coal-fired power plants near Baltimore, Maryland. Short-term mobile and stationary air monitoring of SO2 was conducted from June to September 2013. Maximum 5-minute and 1-hour SO2 concentrations measured near the plants were below levels found to cause respiratory symptoms in clinical studies of healthy exercising asthmatics. The results suggest SO2 exposure levels near the power plants were not likely to elicit respiratory symptoms in sensitive groups.
SPATIAL DISTRIBUTION OF AIRCRAFT NOISE AROUND ABU DHABI INTERNATIONAL AIRPORT...civej
This document summarizes a study that investigated the impact of aircraft noise pollution on community and worker health near Abu Dhabi International Airport. Surveys were conducted in residential neighborhoods and workplaces within 25 km of the airport, which experience high aircraft noise, and in control areas further than 25 km from the airport. The results showed that residents in high noise areas had higher rates of noise stress, hypertension, headaches, sleep problems, and hearing issues compared to the control group. However, aircraft noise was not found to negatively impact the health of workers near the airport. The document reviews previous literature on the health effects of aircraft noise pollution and the methodologies used in the study.
Heavy Metal Contamination in Gelidium Pusillum: A Human Health Risk Assessmen...SaadAldin2
The edible red seaweed Gelidium pusillum is common in Bangladesh, offering a potentially nutritious and healthy source of selenium-rich food for the local population. However, seaweeds can bioaccumulate a range of heavy metals and we assess heavy metal (Fe, Mn, Ni, Cu, As, Zn, Se, and Hg) concentrations in these two seaweed species. Metals were measured in G. pusillum in the order (mg/kg): Fe (797±67) > Mn (69±4) > Ni (12±5) > Zn (9±4) > Cu (9 ± 4) > Se (0.1 ± 0.1) > Hg (0.1 ± 0.01). These levels of metals in the seaweeds pose no risk to human health as part of a normal diet and beneficial levels of selenium.
Effects of Air Pollution on Infant and Children Respiratory Mortality in Four...Kinza Irshad
This study examined the effects of air pollution on infant and child respiratory mortality in four large Latin American cities: Mexico City, Santiago, Chile, Sao Paulo, and Rio de Janeiro, Brazil. Daily counts of respiratory deaths among infants and children were analyzed in relation to particulate matter (PM10) and ozone (O3) levels using statistical models. The results found small increases in risk of respiratory mortality among infants and children associated with higher PM10 and O3 levels, with the strongest effects seen for lower respiratory infections among infants. The study adds to evidence that air pollution exposure can negatively impact children's respiratory health.
2013 A miniature fiber optic blood pressure sensor and its application in in-...Marco Hernandez
A miniature fiber optic sensor was used to measure blood pressure in a swine model. The sensor was inserted into the coronary artery of a swine via a guiding catheter. It measured blood pressure signals in the aortic arch and right coronary artery, with a standard invasive manometry method as a reference. A balloon was inflated in the catheter to simulate a stenosis, and the fiber optic sensor recorded the resulting blood pressure drop. The experiment demonstrated the fiber optic sensor's ability to measure blood pressure in vivo and potential for use in fractional flow reserve techniques to evaluate coronary artery stenosis.
Evaluation of Plasma Creatine Kinase Activity and Inorganic Phosphate among S...IOSRJPBS
Background: CK and phosphorus are helpful biomarker for detection of early renal abnormality particularly CK which has been shown to be abetter predicator of acute renal failure. Objectives: This is a descriptive cross-sectional study. Conducted in Khartoum and White Nile state from March to June 2016.The aim of this study to assess serum creatine kinase (CK) activity and inorganic phosphate concentrations in Sudanese patients with sickle cell anemia. 80 subjects were enrolled in this study they were classified into 40 with sickle cell disease (SCD) as casegroup and 40 healthy apparently as control group. CK activity and phosphorus level was measured by using Spectrophotometry method. Results: The results showed significantly higher Ck activity in patients with SCD when compared with control group with (P = 0.021), and not significant differences in mean of serum phosphorus concentration in case when compared with control with (P = 0.547). Also show serum CK activity in patients used hydroxyurea when compare with the mean of patients not used hydroxyurea it is significantly decrease with (P= 0.006). Conclusion: The studies conclude that Sickle cell disease is a predictor for high serum CK activity and low serum concentration of inorganic phosphate
The document summarizes various health risks associated with living in close proximity to highways. It finds that living within 500 feet of a highway is associated with exacerbation of asthma, impaired lung function, increased risk of heart disease, and adverse birth outcomes. It reviews studies from the Health Effects Institute and others that have empirically linked traffic-related air pollution to increased risks of lung cancer, cardiovascular mortality, COPD, atherosclerosis, pre-term birth, and low birth weight. The document advocates testing for and remediating lead in the soil at the proposed housing development site due to its location within 500 feet of a major highway.
This study investigated the effects of reducing indoor air particle levels through air filtration on microvascular function and biomarkers in elderly adults. The researchers conducted a randomized crossover study where 21 elderly couples were exposed to either filtered or nonfiltered indoor air in their homes for 48 hours. Microvascular function was assessed by measuring digital artery tone after induced ischemia and was significantly improved by 8.1% after indoor air filtration, suggesting short-term particle exposure reduction can benefit cardiovascular health in the elderly. Secondary biomarkers were not significantly changed after correction for multiple comparisons. The study provides evidence that indoor air particles negatively impact endothelial function and reducing exposure may help reduce cardiovascular disease risk.
- 60 apoE-/- mice were exposed to either clean filtered air, concentrated ambient particles (CAPs), 200 ppb ozone (O3), or both CAPs and O3 for 5 hours/day, 4 days/week for 8 weeks.
- Mice exposed to CAPs and CAPs with O3 showed the greatest increases in systolic and diastolic blood pressure compared to the air control group. The blood pressure increase appeared to be driven by PM exposure rather than the combined exposure to O3.
- Exposure to CAPs significantly raised blood pressure in the atherosclerosis-susceptible mice, while O3 exposure alone had a lesser effect. This highlights the importance of PM exposure in
Air Pollution and Exercise: Cardiovascular Implicationnihal Ashraf
This document discusses the effects of air pollution on cardiovascular health and exercise capacity. It finds that exposure to elevated levels of air pollutants is associated with increased blood pressure and heart rate as well as decreased pulmonary function and physical exercise capacity. Specific pollutants like particulate matter and carbon monoxide are shown to reduce measures of exercise performance like work output and maximal oxygen consumption. The mechanisms through which air pollution impacts the cardiovascular system and exercise include airway inflammation, effects on blood flow and oxygen transport, and increased oxidative stress.
Many studies have shown that the increased atmospheric concentration of pollutants has an intensified health risk on lung-, heart- and cardiovascular disease sufferers, as well as the increasing willingness of morbidity and mortality. Therefore, the monitoring of the air pollutants is particularly important. The goal of the recent study was to show a complex picture about Veszprém county’s air quality situation and to discover the relationships between the selected air pollutants (PM10, CO, NO2, SO2, O3) concentration and the picked health diseases (cardiovascular diseases, respiratory diseases, gastrointestinal disorders, ischemic heart disease, cerebrovascular disease, and chronic lower respiratory diseases). Ambient air pollution and hospital admission data for the research were obtained for 2005–2013. According to the calculations; it was found that there was a moderate relation between the air pollutants concentrations and the health diseases.
The document discusses the relationship between air pollution and heart disease. It notes that air pollution contributes to both acute and long-term cardiovascular issues like heart attacks, strokes, heart failure and arrhythmias. The main pollutants of concern are particulate matter and gases like ozone, nitrogen dioxide and volatile organic compounds which are emitted through combustion. Long-term exposure is associated with increased risks of coronary artery disease, heart failure, and cerebrovascular disease through mechanisms like oxidative stress, inflammation and endothelial dysfunction.
A national study on long-term exposure to air pollution to human health and correlation to COVID-19 mortality - pollution kills and every 1ug/m3 PM 2.5 increases the death rate from COVID by 15%.
Evaluation of Haematological, Hepatic and Renal Function of Auto Drivers in T...IOSRJPBS
Background: Episodes of severe air pollution in Asia have been reported in the scientific literature of recent times. The WHO 2005 report Health effects of transport-related air pollution provides the first comprehensive assessment of air pollution related to road transport and of the risks it presents to human health. Environmental pollution has many facets, and the resultant health risks include diseases in almost all organ systems. In this respect, auto rickshaw drivers are at risk, since they are continuously exposed to emissions from vehicles, due to the nature of their job. In view of this, this study is undertaken. Aim And Objectives: The aim of the study is to evaluate the haematological, renal and liver functions of auto drivers in Tirunelveli city and compare it with age and socio demographically matched controls. Materials And Methods: Following inclusion and exclusion criteria, twenty five auto drivers and twenty five controls were investigated for haematological, renal and liver functions. Results: Red blood cell count, haemoglobin level, and Haematocrit level were significantly lower in auto drivers than the control group. Liver enzymes and renal functions showed statistically non significant difference between both groups except for alanine aminotransferase (ALT) which was significantly higher in auto drivers. Conclusion: Work exposure to petroleum products inhalation has health implications as seen by the haematological, and liver function changes. Such group of workers need to be sensitized about the hazards of exposure, appropriate preventive strategies and periodic medical examination.
This document summarizes a study on the economic impact of automobile air pollution-linked diseases in Rewa, India. The study surveyed two areas, Sirmour Chauk and a bus stand, and found higher rates of respiratory, cardiovascular, gastrointestinal and skin diseases at the bus stand, which had higher traffic pollution. The annual health cost was also higher at the bus stand, with total expenditures of 572,244 rupees compared to 509,537 rupees at Sirmour Chauk. The study concludes that traffic from vehicles is a major source of air pollution in Rewa and causes significant health problems and economic costs.
Study: Perinatal Outcomes and Unconventional Natural Gas Operations in Southw...Marcellus Drilling News
This study investigated the association between proximity to unconventional natural gas operations (UGD) in Pennsylvania and perinatal outcomes using birth records from 2007-2010. Mothers were categorized into exposure groups based on the number and distance of gas wells within 10 miles of their residence. After adjusting for confounding factors, the highest exposure group had slightly lower average birth weights and a higher rate of babies born small for gestational age compared to the lowest exposure group, though clinical significance is unclear. Larger longitudinal studies are needed to better evaluate potential health impacts of UGD.
The document describes an epidermal device that can noninvasively map blood flow both macrovascularly and microvascularly in a precise and continuous manner. The device uses an array of thin thermal actuators and sensors that intimately conform to the skin to monitor subsurface blood flow. Experimental studies on humans validate that the device can accurately measure directional blood flow in large veins under various physiological conditions as well as changes in microvascular flow from actions like deep breathing. Quantitative models are used to convert the thermal measurements into estimates of blood flow rates. The low-profile, soft design allows for potential long-term monitoring during daily activities.
This service provides free independent abstracts of medical publications. The abstracts are reviewed by the IPCRG research team to ensure relevance and accuracy. The abstracts summarize the main ideas but do not constitute treatment recommendations. Feedback on the abstracts is welcome.
The document describes an ultrathin, soft, skin-conforming sensor technology that can noninvasively and precisely map both macrovascular and microvascular blood flow. The sensor consists of an array of thin metallic thermal actuators and sensors that conform intimately to the skin through van der Waals forces. Experimental studies on human subjects demonstrate the sensor's ability to sensitively and accurately measure directional blood flow in large subsurface vessels and changes in near-surface microvascular flow induced by breathing and skin stimulation. An advanced pulsed operation mode offers potential for long-term continuous monitoring by reducing drift and power consumption.
NRDC claims that power plant emissions cause 30,000 premature deaths annually from fine particulate matter and ozone. However, the paper finds these claims are implausible. Sulfate, the main component of particulate matter from power plants, is not toxic. Additionally, regulatory costs intended to reduce emissions ultimately cause harm to public health by reducing incomes and ability to invest in health and safety. The large costs of proposals like the Clean Power Act are unlikely to provide significant health benefits.
1. The study analyzed the association between air pollution (PM2.5 and O3) and mortality in Los Angeles using a cohort from the American Cancer Society and controlling for individual and neighborhood factors.
2. It found that all-cause mortality was associated with higher PM2.5 levels, with a relative risk of 1.17 for each 10 μg/m3 increase in PM2.5. Risks were higher for deaths from ischemic heart disease and lung cancer.
3. The results provide evidence that intra-city variations in air pollution exposure lead to stronger health effects than prior studies using average exposures across cities, suggesting localized pollution drives additional health impacts.
Physico-Chemical Analysis of Selected Groundwater Samples of Inkollu Mandal, ...IJERA Editor
Physico-chemical parameters of groundwater quality based on Physic-chemical parameters at Inkollu mandal, Prakasam district, Andhra Pradesh, India have been taken up to evaluate its suitability for Drinking purpose. Nine ground water samples were collected from different places of Inkollu mandal of Prakasam district. The quality analysis has been made through the pH, EC, TDS, Total Hardness, Sodium, Potassium, Calcium, Magnesium, Chloride, Sulphate, Nitrate, Fluoride and Iron. By observing the results, it was shown that the parameters from the water samples were compared with WHO (World Health Organization) and BIS (Bureau of Indian Standards), USPH (United state Public health ) for ground water .The results revealed that some parameters were in high concentration and quality of the potable water has deteriorated to a large extent at some sampling locations.
This study estimated community exposure and health risks from sulfur dioxide (SO2) emissions from three coal-fired power plants near Baltimore, Maryland. Short-term mobile and stationary air monitoring of SO2 was conducted from June to September 2013. Maximum 5-minute and 1-hour SO2 concentrations measured near the plants were below levels found to cause respiratory symptoms in clinical studies of healthy exercising asthmatics. The results suggest SO2 exposure levels near the power plants were not likely to elicit respiratory symptoms in sensitive groups.
SPATIAL DISTRIBUTION OF AIRCRAFT NOISE AROUND ABU DHABI INTERNATIONAL AIRPORT...civej
This document summarizes a study that investigated the impact of aircraft noise pollution on community and worker health near Abu Dhabi International Airport. Surveys were conducted in residential neighborhoods and workplaces within 25 km of the airport, which experience high aircraft noise, and in control areas further than 25 km from the airport. The results showed that residents in high noise areas had higher rates of noise stress, hypertension, headaches, sleep problems, and hearing issues compared to the control group. However, aircraft noise was not found to negatively impact the health of workers near the airport. The document reviews previous literature on the health effects of aircraft noise pollution and the methodologies used in the study.
Heavy Metal Contamination in Gelidium Pusillum: A Human Health Risk Assessmen...SaadAldin2
The edible red seaweed Gelidium pusillum is common in Bangladesh, offering a potentially nutritious and healthy source of selenium-rich food for the local population. However, seaweeds can bioaccumulate a range of heavy metals and we assess heavy metal (Fe, Mn, Ni, Cu, As, Zn, Se, and Hg) concentrations in these two seaweed species. Metals were measured in G. pusillum in the order (mg/kg): Fe (797±67) > Mn (69±4) > Ni (12±5) > Zn (9±4) > Cu (9 ± 4) > Se (0.1 ± 0.1) > Hg (0.1 ± 0.01). These levels of metals in the seaweeds pose no risk to human health as part of a normal diet and beneficial levels of selenium.
Effects of Air Pollution on Infant and Children Respiratory Mortality in Four...Kinza Irshad
This study examined the effects of air pollution on infant and child respiratory mortality in four large Latin American cities: Mexico City, Santiago, Chile, Sao Paulo, and Rio de Janeiro, Brazil. Daily counts of respiratory deaths among infants and children were analyzed in relation to particulate matter (PM10) and ozone (O3) levels using statistical models. The results found small increases in risk of respiratory mortality among infants and children associated with higher PM10 and O3 levels, with the strongest effects seen for lower respiratory infections among infants. The study adds to evidence that air pollution exposure can negatively impact children's respiratory health.
2013 A miniature fiber optic blood pressure sensor and its application in in-...Marco Hernandez
A miniature fiber optic sensor was used to measure blood pressure in a swine model. The sensor was inserted into the coronary artery of a swine via a guiding catheter. It measured blood pressure signals in the aortic arch and right coronary artery, with a standard invasive manometry method as a reference. A balloon was inflated in the catheter to simulate a stenosis, and the fiber optic sensor recorded the resulting blood pressure drop. The experiment demonstrated the fiber optic sensor's ability to measure blood pressure in vivo and potential for use in fractional flow reserve techniques to evaluate coronary artery stenosis.
Evaluation of Plasma Creatine Kinase Activity and Inorganic Phosphate among S...IOSRJPBS
Background: CK and phosphorus are helpful biomarker for detection of early renal abnormality particularly CK which has been shown to be abetter predicator of acute renal failure. Objectives: This is a descriptive cross-sectional study. Conducted in Khartoum and White Nile state from March to June 2016.The aim of this study to assess serum creatine kinase (CK) activity and inorganic phosphate concentrations in Sudanese patients with sickle cell anemia. 80 subjects were enrolled in this study they were classified into 40 with sickle cell disease (SCD) as casegroup and 40 healthy apparently as control group. CK activity and phosphorus level was measured by using Spectrophotometry method. Results: The results showed significantly higher Ck activity in patients with SCD when compared with control group with (P = 0.021), and not significant differences in mean of serum phosphorus concentration in case when compared with control with (P = 0.547). Also show serum CK activity in patients used hydroxyurea when compare with the mean of patients not used hydroxyurea it is significantly decrease with (P= 0.006). Conclusion: The studies conclude that Sickle cell disease is a predictor for high serum CK activity and low serum concentration of inorganic phosphate
The document summarizes various health risks associated with living in close proximity to highways. It finds that living within 500 feet of a highway is associated with exacerbation of asthma, impaired lung function, increased risk of heart disease, and adverse birth outcomes. It reviews studies from the Health Effects Institute and others that have empirically linked traffic-related air pollution to increased risks of lung cancer, cardiovascular mortality, COPD, atherosclerosis, pre-term birth, and low birth weight. The document advocates testing for and remediating lead in the soil at the proposed housing development site due to its location within 500 feet of a major highway.
This study investigated the effects of reducing indoor air particle levels through air filtration on microvascular function and biomarkers in elderly adults. The researchers conducted a randomized crossover study where 21 elderly couples were exposed to either filtered or nonfiltered indoor air in their homes for 48 hours. Microvascular function was assessed by measuring digital artery tone after induced ischemia and was significantly improved by 8.1% after indoor air filtration, suggesting short-term particle exposure reduction can benefit cardiovascular health in the elderly. Secondary biomarkers were not significantly changed after correction for multiple comparisons. The study provides evidence that indoor air particles negatively impact endothelial function and reducing exposure may help reduce cardiovascular disease risk.
- 60 apoE-/- mice were exposed to either clean filtered air, concentrated ambient particles (CAPs), 200 ppb ozone (O3), or both CAPs and O3 for 5 hours/day, 4 days/week for 8 weeks.
- Mice exposed to CAPs and CAPs with O3 showed the greatest increases in systolic and diastolic blood pressure compared to the air control group. The blood pressure increase appeared to be driven by PM exposure rather than the combined exposure to O3.
- Exposure to CAPs significantly raised blood pressure in the atherosclerosis-susceptible mice, while O3 exposure alone had a lesser effect. This highlights the importance of PM exposure in
Air Pollution and Exercise: Cardiovascular Implicationnihal Ashraf
This document discusses the effects of air pollution on cardiovascular health and exercise capacity. It finds that exposure to elevated levels of air pollutants is associated with increased blood pressure and heart rate as well as decreased pulmonary function and physical exercise capacity. Specific pollutants like particulate matter and carbon monoxide are shown to reduce measures of exercise performance like work output and maximal oxygen consumption. The mechanisms through which air pollution impacts the cardiovascular system and exercise include airway inflammation, effects on blood flow and oxygen transport, and increased oxidative stress.
Many studies have shown that the increased atmospheric concentration of pollutants has an intensified health risk on lung-, heart- and cardiovascular disease sufferers, as well as the increasing willingness of morbidity and mortality. Therefore, the monitoring of the air pollutants is particularly important. The goal of the recent study was to show a complex picture about Veszprém county’s air quality situation and to discover the relationships between the selected air pollutants (PM10, CO, NO2, SO2, O3) concentration and the picked health diseases (cardiovascular diseases, respiratory diseases, gastrointestinal disorders, ischemic heart disease, cerebrovascular disease, and chronic lower respiratory diseases). Ambient air pollution and hospital admission data for the research were obtained for 2005–2013. According to the calculations; it was found that there was a moderate relation between the air pollutants concentrations and the health diseases.
The document discusses the relationship between air pollution and heart disease. It notes that air pollution contributes to both acute and long-term cardiovascular issues like heart attacks, strokes, heart failure and arrhythmias. The main pollutants of concern are particulate matter and gases like ozone, nitrogen dioxide and volatile organic compounds which are emitted through combustion. Long-term exposure is associated with increased risks of coronary artery disease, heart failure, and cerebrovascular disease through mechanisms like oxidative stress, inflammation and endothelial dysfunction.
A national study on long-term exposure to air pollution to human health and correlation to COVID-19 mortality - pollution kills and every 1ug/m3 PM 2.5 increases the death rate from COVID by 15%.
Evaluation of Haematological, Hepatic and Renal Function of Auto Drivers in T...IOSRJPBS
Background: Episodes of severe air pollution in Asia have been reported in the scientific literature of recent times. The WHO 2005 report Health effects of transport-related air pollution provides the first comprehensive assessment of air pollution related to road transport and of the risks it presents to human health. Environmental pollution has many facets, and the resultant health risks include diseases in almost all organ systems. In this respect, auto rickshaw drivers are at risk, since they are continuously exposed to emissions from vehicles, due to the nature of their job. In view of this, this study is undertaken. Aim And Objectives: The aim of the study is to evaluate the haematological, renal and liver functions of auto drivers in Tirunelveli city and compare it with age and socio demographically matched controls. Materials And Methods: Following inclusion and exclusion criteria, twenty five auto drivers and twenty five controls were investigated for haematological, renal and liver functions. Results: Red blood cell count, haemoglobin level, and Haematocrit level were significantly lower in auto drivers than the control group. Liver enzymes and renal functions showed statistically non significant difference between both groups except for alanine aminotransferase (ALT) which was significantly higher in auto drivers. Conclusion: Work exposure to petroleum products inhalation has health implications as seen by the haematological, and liver function changes. Such group of workers need to be sensitized about the hazards of exposure, appropriate preventive strategies and periodic medical examination.
This document summarizes a study on the economic impact of automobile air pollution-linked diseases in Rewa, India. The study surveyed two areas, Sirmour Chauk and a bus stand, and found higher rates of respiratory, cardiovascular, gastrointestinal and skin diseases at the bus stand, which had higher traffic pollution. The annual health cost was also higher at the bus stand, with total expenditures of 572,244 rupees compared to 509,537 rupees at Sirmour Chauk. The study concludes that traffic from vehicles is a major source of air pollution in Rewa and causes significant health problems and economic costs.
This document discusses the high burden of cardiovascular disease (CVD) in India and the link between air pollution and increased risk of CVD. It provides the following key points:
1. CVD is the leading cause of death in India, with rates higher than global averages. Major CVDs include IHD, cerebrovascular disease, and hypertension.
2. Risk factors for CVD like hypertension and diabetes are rising dramatically in India and projected to affect hundreds of millions by 2030.
3. Existing evidence suggests air pollution likely increases the risk of CVD and its risk factors through mechanisms like endothelial dysfunction, inflammation, and increased blood pressure.
4. Research aims to better characterize the associations between long-term air
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2. Background
Elevated exposure to ambient outdoor air pollution (AP)
has been shown to contribute to acute and chronic
health effects in the Canadian population [1, 2], and glo-
bally as well [3–6]. Specifically, chronic exposure to ele-
vated ambient AP has been linked to increased risk of
all-cause mortality [6], as well as cardiovascular and pul-
monary morbidity and mortality [3, 4]. More recent
studies have linked ambient AP to acute effects on hu-
man health [2, 4, 7], and more specifically cardiovascular
morbidity and mortality, including increased risks of car-
diac rhythm disturbance [2]. Data suggest that both
acute and chronic effects of AP are related to oxidative
stress and activation of stress pathways, including the
autonomic nervous system [4].
Heart rate (HR), and variations in HR at the beat-to-
beat level are dependent on the activity of the intrinsic
cardiac pacemaker, the sino-atrial node [8]. Sino-atrial
nodal function and discharge rate are influenced by
autonomic inputs, which can be subdivided into the ex-
citatory sympathetic and inhibitory parasympathetic ner-
vous system effects. One approach to look at the balance
of sympathetic and parasympathetic function is the
study of Heart Rate Variability (HRV) [8, 9]. HRV is de-
termined by autonomic nervous system and circulating
hormonal inputs at the sino-atrial node [4, 9, 10]; and is
measured by comparing the variations in time between
R-waves (ventricular depolarization) from a continuous
electrocardiogram [9, 10]. Only normal (sino-atrial
nodal) beats are counted, therefore the time between
beats is referred to as the normal to normal, or N-N,
interval [9, 10]. Reduced HRV has been linked to in-
creased risk of cardiovascular mortality and morbidity in
vulnerable populations, including the elderly [11], dia-
betics and heart failure patients [12], and has been
shown to be predictive of all-cause mortality risk in
healthy populations [12].
Exposure to single air pollutants, pollution mixtures
and/or concentrated particulate matter has been shown
to influence HRV. In controlled exposure studies HRV
has been shown to be responsive to individual pollutants
and pollutant mixtures; specifically ultrafine particulate
matter (UFP) [13], concentrated ambient particulate
matter, and ozone [14]. In panel and crossover studies of
the effects of ambient air pollution on health, significant
changes in HRV also have been reported. Significant de-
creases in high frequency (HF) power of HRV were seen
when cyclists cycled in high traffic areas, compared to
when they cycled in low traffic or indoors [15]. Nyhan et
al. [16] found that particulate matter dose (concentra-
tion*respiration rate) was significantly inversely associ-
ated with the time domain of HRV in a group of
commuters using bus, train, bike or foot transport [16].
Many studies of acute effects of AP exposure on
autonomic function through HRV analyses have focused
on exposures to traffic-related ambient AP [14–17]; how-
ever, few studies have examined the acute effects of expos-
ure to ambient AP from industrial sources.
In the summer of 2010 we conducted a novel ambient
AP exposure crossover study. The study compared
physiological and biological responses in healthy volun-
teers who had spent time outdoors either at a location in
a neighbourhood, called Bayview, adjacent to a steel mill,
or at a college campus several kilometers from the steel
mill. Previous reports of the results from this study have
focussed on pulmonary function [18] and cardiovascular
function [19], as well as the role of metals composition in
the effects of particulate matter on pulmonary and cardio-
vascular function [20]. The current report focuses on as-
sociations between proximity to a steel plant and acute
(same day) changes in HRV. We hypothesised that (1)
HRV would be significantly different at the Bayview site
when compared with the College site; (2) AP exposure be-
tween the two sites would differ significantly; and (3) that
changes in levels of single pollutants would be associated
with changes in HRV.
Methods
Study design and AP exposure assessment
The study was approved by the Health Canada Re-
search Ethics Board (reference number 2009-0044)
and the ethics board at Algoma University. Study de-
sign and detailed methods of the study protocol have
been reported previously [18–20]. Briefly, eligible
study participants were recruited through postings at
local university and college campuses. The partici-
pants were non-smokers aged 18–55 years, permanent
or seasonal residents of Sault Ste. Marie Ontario, who
did not work or live near the steel plant. All partici-
pants completed an ethics board approved informed
consent process. Participants had no history of car-
diovascular, respiratory or metabolic disorders and did
not use medications that could influence inflamma-
tory processes or cardio-respiratory function. Partici-
pants were randomized into two different crossover
arms for the study. Participants spent five consecutive
eight hour days outdoors at one of two study sites; at
the Bayview neighborhood near the steel plant prop-
erty or at a college campus approximately five km
from the plant site. Participants had a minimum of
nine days of washout away from the study sites be-
fore being assigned to the other exposure scenario.
Ambient hourly pollutant levels (CO, NO, NO2, NOx,
O3, SO2 & PM2.5) temperature, humidity and rainfall
were determined at each study site using fixed site
monitors (Air Pointer, recordum Messtechnik GmbH,
Modling, Austria). Ultrafine particles (UFP) were mea-
sured using the TSI Model 3007 UFP counter. Daily AP
Shutt et al. Environmental Health (2017) 16:4 Page 2 of 10
3. exposures were assigned to study participants based on
the mean levels of each pollutant during the time the par-
ticipant was on site, up to and including the time point at
which HRV parameters were measured.
Measurement of HRV parameters
For measurement of HRV, participants were hooked up to
a 12-lead ambulatory ECG monitor (Mortara H12+ Holter
Monitor, Mortara Instrument Inc. Milwaukee, WI, USA)
by trained technicians following standard procedures [21].
The H12+ system was selected for the high sampling fre-
quency (10 000 samples/sec/channel), as is recommended
for research purposes. Data were screened using the
Mortara H-scribe workstation, and then transferred to
Nevrokard aHRV software (Nevrokard Kiauta, d.o.o.,
Slovenia) for additional analysis. Data screening was
performed by trained ECG technicians to confirm
automatically identified ectopic beats, identify and exclude
areas of low recording quality on some channels, and to
select five minute periods for HRV analysis. Wherever
possible the five minute analysis periods were selected at
the end of a minimum 15 min sedentary rest period. For
the purposes of this paper all data presented are from a
25 min rest period near the end (sixth hour) of the eight
hour on-site day. HRV analysis of the listed parameters
was completed using the Mortara and Nevrokard soft-
ware, and following the HRV Measurement Standards
established in the 1996 European Society of Cardiology
and The North American Society of Pacing and Electro-
physiology guidelines [9, 10]:
Time Domain: SDNN - Standard Deviation of the N to
N intervals, in ms.
RMSSD - Root mean square of the sucessive
differences in ms.
pNN50 - The percentage of pairs of adjacent N to N
intervals that differ by more than 50 ms.
Frequency Domain: Analysis of the frequency domain
was completed using non-parametric, Fast Fourier
transformation methods.
LF Power – Power in the low frequency range
(0.04–0.15 Hz), in ms2
.
HF Power – Power in the high frequency range
(0.15–0.4 Hz), in ms2
.
Additionally, heart rate (Normal beats per minute) was
calculated for the HRV analysis period for use as a co-
variate in HRV analysis, and the ratio of LF power to HF
power (LF/HF) was calculated for inclusion in the Fre-
quency Domain data analysis [9, 10].
Statistical analyses
Statistical analysis methods were similar to those de-
scribed in Dales et al. [18], however only acute (same day)
associations were considered.
Analysis of site and HRV
Associations between study site and HRV parameters
were measured with mixed effects linear regression
models, matched for study participant and day of the
week. Covariates in the analyses included HR, age, sex,
body mass index, temperature and relative humidity.
Demographic, HRV and exposure databases were merged
and statistical analyses were completed with SAS EG, v4.2
(Cary, NC, USA).
Analysis of site differences in AP levels
The levels of exposure to pollution for participants at
the Bayview site were compared to their exposure levels
at the College site with student’s t-tests.
Analysis of individual pollutants and HRV
Associations between individual daily average pollutant
exposure concentrations and daily changes in HRV for
the two sites combined were determined. Individual
daily pollutant exposures were determined based on the
mean exposure levels for the specific participant’s time
at the study site up to and including the hour of the
HRV time point. The associations between concentrations
of individual pollutants and HRV parameters measured
on the same day were examined using mixed effects linear
regression models. Covariates in this analysis included
HR, age, sex, BMI, temperature and relative humidity with
the addition of study site. Sample size was inadequate to
complete subgroup analyses. The final model contained
the selected variables and covariates if they were signifi-
cant at p <0.05 or if they confounded the exposure-
outcome relationship (i.e. a change of 10% in the coeffi-
cient for exposure).
Results
Sixty participants completed at least part of each of the
5-day exposure scenarios (Bayview and College sites)
and were included in the statistical analyses presented
here. Descriptive statistics for the cohort are presented
in Table 1. We compared afternoon HR and HRV pa-
rameters at the Bayview site with HR and HRV at the
College site to test our first hypothesis, that cardiac
autonomic balance, as described by HRV, would be al-
tered at the Bayview site. HR was slightly (2.8%) but sig-
nificantly elevated at the Bayview site, when compared
to the College site (Fig. 1). Components of the time do-
main of HRV decreased significantly at Bayview when
compared to College (Fig. 1). SDNN and pNN50 were
significantly reduced at the Bayview site when compared
Shutt et al. Environmental Health (2017) 16:4 Page 3 of 10
4. to the College site. SDNN was reduced by nearly 13%,
while pNN50 showed an 8.2% reduction (Mean and con-
fidence intervals are reported in Fig. 1). The frequency
domain of HRV also was affected by site (Fig. 2). There
was a significant reduction (8.4%) in LF power at the
Bayview site (Fig. 2) when compared to the College site;
however there was no effect of site on either the HF
power or the LF/HF ratio.
Our second hypothesis was that, given the proximity
of the Bayview site to the steel plant, AP exposure would
differ significantly between the Bayview and College
sites. In order to examine this hypothesis we first looked
at the participant specific ambient AP exposures, by site
(Table 2). AP exposure differed significantly between
sites; mean levels of CO, NO, NO2, NOx, SO2, PM2.5 and
UFP all were significantly elevated at the Bayview site,
adjacent to the steel plant. Ozone was significantly lower
at the Bayview site, but only represented an 8% difference
in O3 levels when compared to the College site.
Once it was determined that the AP exposures at the
two sites differed, we tested our third hypothesis; that
changes in levels of individual pollutants would be asso-
ciated with changes in HRV, regardless of site. For this
analysis participant specific AP exposures were deter-
mined to investigate the effects of interquartile range
(IQR) changes in individual pollutant exposures on HRV
(Table 3 shows IQR for each pollutant, exposures at both
sites were combined). The models predicted small but
significant increases in HR for IQR (see Table 3) changes
in CO, NO, NO2, NOx, SO2 and UFP. The time domain
of HRV, including SDNN, RMSSD and pNN50, was sig-
nificantly associated with IQR increases in pollutant
levels (Table 3). Associations between the time domain
of HRV and IQR changes in pollutant levels were consist-
ently inverse (increasing levels of pollutants associated
with decreasing HRV). IQR changes in all pollutants but
ozone were significantly associated with small (1–10%)
but significant reductions in SDNN. IQR changes in NO,
PM2.5 and UFP were associated with consistent (~5%) re-
ductions in pNN50. Significant inverse associations be-
tween individual pollutant levels and RMSSD were seen
with NO2, NOx, SO2 and PM2.5 (Table 3). No significant
positive associations between any of the reported pollut-
ants and the Time Domain of HRV were found (Table 3).
We also saw significant associations between changes
in levels of individual pollutants and the Frequency Do-
main of HRV (Table 3). IQR increases in CO, NO, SO2,
PM2.5 and UFP all were significantly inversely associated
with LF power. It should be noted that these associa-
tions, while statistically significant, represent small
changes in LF Power (0.1–0.2% reductions) when com-
pared with those associated with the College vs Bayview
sites. The patterns of associations, while generally in-
verse, between IQR range changes in AP and HF power
and the ratio of HF to LF power were less clearly de-
fined, and few reached statistical significance. Small but
significant inverse associations were found between HF
power and O3 and PM2.5, as well as a significant inverse
association between O3 and HF/LF. No significant posi-
tive associations or trends towards positive associations
were seen in the Frequency Domain of HRV (Table 3).
We also tested to determine if individual pollutant
levels were correlated with one another. We pooled the
pollutant exposure data, irrespective of site, and exam-
ined the Pearson Product Moment Correlations between
pollutants (Additional file 1: Table S1). Levels of both
NO and NO2 were very strongly correlated with NOX
levels. NO and NO2 were strongly correlated. NO2 and
NOX also showed strong correlations with levels of SO2.
Levels of NO2 were moderately correlated with levels of
Table 1 Participant demographics
Mean SD
Age (years) 24.2 5.8
Height (cm) 173.1 9.9
Weight (kg) 78.7 20.2
BMI 26.1 5.8
Percentage N
Sex, Male 46.0 28
More detailed descriptions of the participant population can be found in Dales
et al., 2013. Age in years, height in centimetres, weight in kilograms and Body
Mass Index (BMI) are presented as the mean for the 60 participants included
in the analysis, with the standard deviation in the second column. 28
participants (46%) were male
Fig. 1 Heart Rate and Time Domain of Heart Rate Variability differed
significantly at the Plant site when compared to the College site. Data
are expressed as the mean of responses measured from the afternoon
ambulatory ECG recording time point. Error bars represent the 5 and
95% confidence limits. Mixed effects linear regressions showed that
the increase in heart rate at the Plant Site, when compared to the
College Site was significant (* = p < 0.05). The decreases in SDNN and
pNN50 at the Plant Site, when compared to the College Site also
were significant
Shutt et al. Environmental Health (2017) 16:4 Page 4 of 10
5. particulates (both fine and ultrafine). NOX levels were
moderately correlated with the concentration of ultrafine
particles. SO2 was strongly correlated with levels of both
NO2 and NOx, and was weakly correlated with NO. SO2
also was very strongly correlated with concentrations of
UFP and moderately correlated with fine particulate
concentrations. O3 was moderately inversely correlated
with NO. Otherwise, only weak correlations between
levels of O3 the other pollutants measured were seen,
and most of those correlations were inverse correlations,
rather than the positive correlations between the other
pollutants (Additional file 1: Table S1).
Discussion
In this study we investigated the effects of acute expos-
ure to ambient AP from an industrial source on cardiac
autonomic function, as described by changes in HRV.
We found small but statistically significant associations
between exposure to ambient AP at a site near a steel
plant and reductions in both time and frequency domain
components of HRV. The associations between exposure
sites and HRV appear to be related to the statistically
significant pollutant exposure contrast between the two
sites, as similar associations were seen in models of the
effects of individual pollutant exposures on HRV. Asso-
ciations between increasing levels of AP and the time
domain showed a consistent inverse relationship, HRV
decreasing as pollutant levels increased. A similar pattern
of associations between AP and the frequency domain was
seen although this may be more challenging to interpret.
An initial report of the effects of ambient AP near the
steel plant on cardiovascular outcomes showed that
pulse rate (PR) was slightly but significantly elevated (ap-
proximately 1.5 bpm) at the plant site [19]. Liu et al.
[19] described significant elevations in PR in response to
IQR increases in SO2 (IQR = 2.9 ppb), NO2 (IQR =
5.0 ppb) and CO (IQR = 0.2 ppb). In the current investi-
gation of the effects of ambient AP near the steel plant
on autonomic function, we also showed a small but sig-
nificant elevation in HR at the Bayview site, when com-
pared to the College site (approximately 2 bpm; Fig. 1)
and small but consistently significant associations be-
tween individual pollutants and HR (Table 3). While we
saw no association between IQR changes in O3 and HR,
Liu et al. [19] did report a significant inverse association.
The difference in this finding, as well as the additional
finding of significant associations between HR and IQR
Fig. 2 Low Frequency Power was significantly reduced at the Plant site. Data are expressed as the mean of responses measured from the
afternoon ambulatory ECG recording time point. Error bars represent the 5 and 95% confidence limits. Mixed effects linear regression
determined that LF power was significantly reduced (* = p < 0.05) at the college site when compared to the plant site, while HF power
and the LF/HF ratio did not differ significantly
Table 2 Comparison of ambient AP levels measured at the
college and Bayview Sites
College site Bayview site
Pollutant Mean (SD) IQR Mean(SD) IQR
CO (ppm) 0.42 (0.11) 0.20 1.24 (1.63)* 0.60
NO (ppb) 1.69 (1.2) 1.30 7.02 (4.16)* 4.90
NO2 (ppb) 4.6 (2.8) 2.90 6.89 (3.64)* 4.60
NOx (ppb) 6.29 (3.66) 2.95 13.74 (6.97)* 8.70
O3 (ppb) 32.44 (7.62) 8.90 29.66 (6.53)* 9.90
SO2 (ppb) 1.78 (2.56) 1.60 8.05 (10.58)* 14.20
PM2.5 (μg/m3
) 11.67 (6.61) 8.20 13.01 (6.87)* 9.90
UFP (particles/cm3
) 6960 (4261) 5560 14654 (13664)* 19648
Mean values are the mean for the participant specific exposure averaged over
the hours of the five days that each individual participant spent breathing
ambient air at the specified site. Pollutant levels were significantly different
between the College and Bayview sites (* = p < 0.05)
Mean temperature at College 23.4 °C (SD 4.1 °C); mean relative humidity
56.0% (SD 15.1%)
Mean temperature at Bayview 23.4 °C (SD 4.1 °C); mean relative humidity
55.9% (SD 14.3%)
Shutt et al. Environmental Health (2017) 16:4 Page 5 of 10
6. changes in NO, NOx and UFP concentrations in this
study may be related to the difference in the sensitivity
and recording duration for HR. In the Liu et al. [19] re-
port, PR was derived from the PR recorded during pulse
oximetry at a different time point than the HR in the
current analysis, which was determined from an ambula-
tory electrocardiogram. In addition, participant specific
AP exposure estimates were based on slightly different
exposure times than those used by Liu and colleagues
[19]. Finally, we might expect some small differences in
results due to the subtle differences in the mixed effects
models used for data analysis, and the number of partici-
pant records available for analysis for each variable and
at each time point. In our analysis IQR increases of most
of the measured pollutants (excluding O3) were signifi-
cantly positively associated with HR and significantly
negatively associated with the time domain of HRV. In-
creased HR and decreased HRV are hallmarks of in-
creased sympathetic input [22].
The effects of exposure to ambient AP from industrial
sites on HRV in healthy young populations have not been
extensively studied, and the effects seen in other studies of
AP mixtures or single pollutants show a high degree of
heterogeneity, with few points of consensus. For example,
in two similar crossover studies of the effects of traffic re-
lated AP exposure on HRV parameters, Weichenthal et al.
[15, 17] found different patterns of effects. In a 2011 study
of urban cyclists Weichenthal et al. [15] found that HF
power was significantly reduced when cycling in high
traffic areas, and HRV was inversely associated with
IQR increases in UFP concentrations [15]. The reported
reductions in HRV in response to increasing pollutant
levels in Weichenthal et al. [15] support the findings of
the current study. In 2014 Weichenthal et al. [17] re-
ported that HRV was affected by traffic related AP in a
population of female cyclists, but the results were unex-
pected in the context of the 2011 study [15, 17]. Specif-
ically, ozone was associated with significant increases in
SDNN and LF/HF ratio, and more surprisingly UFPs
were associated with a significant increase in SDNN
[17]. Additionally, regional background AP levels ap-
peared to be modifying autonomic nervous system sen-
sitivity to short term traffic pollution exposures,
suggesting that an individual’s background AP expo-
sures may modulate acute responses to traffic-related
AP [17]. The consistent inverse associations we report
in this study are not supported by the findings of the
Weichenthal et al. 2014 [17] study. In another study of
healthy young commuters, Nyhan et al. [16] found that
exposure to particulate matter was associated with sig-
nificant reductions in the time domain of HRV. This
finding was stronger in physically active commuters
(cyclists and pedestrians) but also was true for more
sedentary commuters (bus and train) [16]. These find-
ings support the findings of the current study, which
showed significant reduction in the time domain of
HRV associated with IQR increases in PM2.5.
Other studies have investigated the effects of controlled
exposures to components of AP on HRV in healthy sub-
jects. In controlled exposures of healthy young volunteers
to carbon UFP, significant positive associations between
UFP and HRV parameters were reported [13]. The pattern
Table 3 Associations between IQR increases in levels of individual pollutants and components of heart rate variability
Frequency domain Time domain
Pollutant Pollutant
IQR
Heart Rate
(bpm)
HF Power
(ms2
)
LF Power
(ms2
)
HF/LF SDNN
(ms)
RMSSD
(ms)
pNN50
(%)
CO (ppm) 0.30 0.32*
(0.10, 0.54)
-0.39
(-0.89, 0.11)
-3.78*
(-7.41, -0.12)
-0.03
(-0.08, 0.02)
-1.09*
(-2.12, -0.06)
-0.99
(-2.09, 0.11)
-0.38
(-0.80, 0.03)
NO (ppb) 4.40 1.22*
(0.31, 2.14)
-0.56
(-2.61, 1.50)
-1.51*
(-3.01, -0.01)
-0.09
(-0.31, 0.13)
-4.67*
(-8.89, -0.44)
-4.13
(-8.62, 0.35)
-1.77*
(-3.52, -0.02)
NO2 (ppb) 4.30 1.40*
(0.48, 2.32)
-1.101
(-3.17, 0.97)
-1.33
(-2.82, 0.15)
-0.19
(-0.40, 0.03)
-6.41*
(-10.65, -2.17)
-6.02*
(-10.53, -1.52)
-1.17
(-2.94, 0.59)
NOx (ppb) 8.30 1.50*
(0.56, 2.43)
-0.38
(-2.46, 1.71)
-1.46
(-3.00, 0.08)
-0.12
(-0.34, 0.09)
-6.60*
(-10.90, -2.29)
-6.01*
(-10.58, -1.44)
-1.41
(-3.21, 0.38)
O3 (ppb) 8.70 0.30
(-0.66, 1.26)
-2.50*
(-4.67, -0.33)
-2.24
(-17.32, 12.84)
-0.32*
(-0.54, -0.11)
-5.59
(-10.01, 1.18)
-6.11
(-10.87, 1.36)
1.28
(-0.55, 3.10)
SO2 (ppb) 4.60 0.78*
(0.15, 1.41)
-0.82
(-2.24, 0.61)
-1.07*
(-2.13, -0.002)
-0.11
(-0.25, 0.03)
-4.08*
(-7.00, -1.16)
-3.41
(-6.52, -0.31)*
-1.08
(-2.30, 0.13)
PM2.5 (μg/m3
) 9.00 0.97
(-0.04, 1.97)
-2.43*
(-4.62, -0.24)
-1.88*
(-3.46, -0.29)
-0.16
(-0.38, 0.07)
-5.34 *
(-9.96, -0.72)
-5.28*
(-10.15, -0.41)
-1.99*
(-3.91, -0.07)
UFP (particles/cm3
) 12236 1.10*
(0.04, 2.16)
-1.89
(-4.38, 0.60)
-1.61*
(-3.21, -0.01)
-0.15
(-0.38, 0.08)
-7.13*
(-12.27, -1.98)
-5.03
(-10.63, 0.57)
-2.20*
(-4.24, -0.15)
IQR values for participant specific pollutant exposures, combined for both the Bayview and College sites, are shown in the second column. The amplitude of the
change in each HRV parameter associated with an IQR increase in pollutant level and 95% CI (bracketed) are reported for each pollutant/HRV parameter pair.
Statistically significant associations (p < 0.05) are denoted by *
* = p < 0.05. Mean temperature throughout the study was 23.4 °C (SD 4.1 °C); mean relative humidity was 56.0% (SD 14.7%)
Shutt et al. Environmental Health (2017) 16:4 Page 6 of 10
7. of effects suggested that peripheral nervous system tone
was elevated following exposure to low levels of UFP,
but not at higher concentrations [13]. In our study,
when the associations between HRV parameters and
IQR changes in UFP were tested, we saw significant in-
verse associations with some measures, and all trends
were consistently inverse, suggesting an increase in
sympathetic tone. Controlled exposure to concentrated
ambient particles [14] was positively associated with
the frequency domain of HRV, and these changes were
larger following co-exposure to particles and O3. Individ-
ual pollutants may interact in ambient pollutant mixtures
to enhance or alter the autonomic effects of AP.
In future analyses it may be important to consider in-
teractions between pollutants or to generate multi-
pollutant models to better test the associations between
AP and autonomic effects. We tested the degree of cor-
relation between individual pollutants irrespective of site,
and found that most pollutants were significantly posi-
tively correlated with one another. We found consistent,
moderate to strong, positive correlations between the Ni-
trogen oxides and also SO2 (Additional file 1: Table S1).
This, taken with our findings of consistent inverse asso-
ciations between these individual pollutants and HRV,
suggests that the high degree of correlation between in-
dividual pollutants may contribute to the consistency of
the effect. It may be important to investigate the effects
of controlled exposure to individual pollutants and spe-
cific mixtures to tease out which pollutants are primar-
ily responsible for the effects on HRV. However, if we
consider our site-specific analysis as a method to inves-
tigate the effects of pollutant mixtures on HRV, the pol-
lutant mixture at the Bayview site was associated with
significant reductions in HRV when compared to the
mixture at the College site. We also took a second mul-
tipollutant approach, by testing the associations be-
tween IQR changes in the Air Quality Health Index
(AQHI) and HRV parameters. The AQHI is a health in-
formation tool, calculated from ambient O3, NO2, and
PM2.5 [23]. It is used to communicate the health risks
of AP to the public. Previous studies [2, 24–27], how-
ever, also have used the AQHI as a unique 3 pollutant
summary of AP, and tested its associations with health
effects, including asthma [25, 26] and cardiovascular
outcomes [2, 24]. In our study the AQHI was not signifi-
cantly associated with changes in any of the HRV parame-
ters tested (Additional file 2: Table S2). A detailed
description of the AQHI and the results can be found in
the table and legend for Additional file 2: Table S2.
Healthy younger individuals have been followed in two
different panel studies of ambient AP effects in Taiwan
[28, 29]. Chuang et al. [28] reported consistent inverse
associations between ambient AP levels and both time
and frequency domains of HRV. These results were
similar to the results of the current study, although some
of the patterns of effect differed. Chuang et al. [28] also
reported associations between AP and elevated blood
levels of biomarkers of oxidative stress, suggesting that
oxidative stress may be involved in the altered auto-
nomic function. In mail carriers in Taiwan, IQR changes
in PM2.5 were not significantly associated with changes
in HRV [29]. The lack of significant associations re-
ported by Wu et al. [29] are especially surprising in light
of the much higher exposure experienced by the mail
carriers (PM2.5 IQR = 52) when compared to the expo-
sures in the current study (IQR = 9), where we reported
significant inverse associations. It is possible that the
lack of significant associations in the mail carriers study
[29] was related to a lack of exposure contrast, since no
crossover to a different exposure scenario was com-
pleted, and background exposures may have been similar
or higher. Taken together, the results of the current
study with results from other studies in healthy younger
study populations [13–17, 28, 29] appear to show that
depending on pollutants, exposure metric, and timeline
the effects of AP on autonomic nervous system function
can show slightly different patterns of effects; however
throughout all the studies, the overall message appears to
be that exposure to AP can alter cardiac autonomic bal-
ance in the absence of other disease states or risk factors.
When we examined the associations between LF
power and site alone or LF power and individual pollut-
ants, LF showed significant inverse associations. The in-
puts which might influence changes in LF power are
less clearly defined than those for HF power or the ra-
tio of LF:HF. Changes in HF power are consistently
linked to changes in parasympathetic input [8, 9, 22].
Some researchers therefore have hypothesized that
changes in LF power might be evidence of sympathetic
effects [22], while others suggest that such change rep-
resents both sympathetic and parasympathetic activity
[9] but there is no clear consensus, and it is difficult to
interpret the individual findings with respect to LF
power. Other studies of healthy younger volunteers
have reported significant changes in LF power [14, 28],
in the absence of effects on other components of the
frequency domain of HRV. While reductions in HF
were linked to pollutant and particulate matter expos-
ure in diabetics [30], the elderly [31] and individuals
with a history of hypertension or ischemic heart disease
[31], this was not seen in healthy young volunteers
[30]. These findings seem to point to a difference in the
response to pollutant exposure of the frequency do-
main. LF power appears to be inversely associated with
increasing AP in healthy young study participants in
this study and others [14, 28], while AP exposure in
members of vulnerable populations has been associated
with changes in HF power [30, 31].
Shutt et al. Environmental Health (2017) 16:4 Page 7 of 10
8. The associations between AP and HRV reported in
this study were small. This may be related to the study
population, who were a group of healthy and relatively
young volunteers, rather than members of susceptible
populations. The changes in HRV were statistically sig-
nificant and followed consistent patterns of effect, espe-
cially within the time domain of HRV. The consistent
patterns of association suggest that these effects repre-
sent real changes in autonomic function in response to
changing AP rather than spurious associations. Ambient
AP levels in this study were consistent with generally
low Canadian ambient AP levels [32], and therefore are
relevant to Canadians. Additionally, the outdoor expos-
ure location close to the steel plant was adjacent to a
residential neighbourhood; therefore, ambient AP expo-
sures at the Bayview site reflected real world ambient
AP exposure. It is possible that, had pollutant levels
been higher, and the exposure contrast been greater, a
larger effect of proximity to the industrial site, and of
pollutant exposure, on autonomic nervous system func-
tion could have been recorded. That said, our statisti-
cally significant findings at relatively low levels of
pollution, and with a small exposure contrast between
study sites, provide us with important information
about the autonomic effects of small changes in AP
when AP levels are low. The crossover design of the
study was a great strength, allowing us to contrast the
health effects of exposure to AP near a steel plant and
at a site farther from the plant. In the crossover design
participants act as their own controls, reducing the po-
tential for confounding by time-invariant individual
characteristics such as age, sex, social status, residential
air quality, and medical history. Some bias may have
been introduced into the study due to the nature of the
crossover design. It was not possible to blind the study
participants or study team to the exposure arm, as the
exposure was location specific, and the Bayview site
was within view of the steel plant. The analysis of asso-
ciations with individual pollutant levels, however, which
pooled all pollutant exposures by participant irrespect-
ive of site, would have mitigated some of the bias intro-
duced by the site dependence of the primary study
design. The Sault Ste Marie Crossover study as a whole
was a randomized controlled crossover study where the
exposure conditions were not artificial, but rather were
real world exposures, and therefore the significant re-
sults that this study has yielded may be generalizable to
the Canadian population.
The results of our study, taken together with other
studies, indicate that the patterns of changes in auto-
nomic function associated with exposure to AP may dif-
fer between young healthy individuals and vulnerable
individuals. Reductions in HF power are linked to pollu-
tant and particulate matter exposure in diabetics [30]
and the elderly [31], while this study, as well as Fakhri
et al. [14] and Chuang et al. [28] reported few associa-
tions between AP and HF power, but significant inverse
associations with LF power, all in healthy, younger pop-
ulations. Despite the less clear pattern of significant as-
sociations with the frequency domain of HRV, HR and
the time domain of HRV showed consistent significant
inverse associations with changes in HRV. This is indi-
cative of either reduced parasympathetic activation or
enhanced sympathetic activation [22]. Increased sympa-
thetic activation could be indicative of increased sys-
temic stress, and would have wide ranging physiological
consequences. Recent animal studies have shown that
hypothalamic-pituitary axis and the autonomic nervous
system may be activated by inhaled particulate and/or
gaseous AP [33, 34]. Recent studies have pointed for a
role of increased sympathetic activity in the health effects
of AP [4, 34], however these alterations in autonomic
function may be a direct mechanism of the health effects
of ambient AP, or they may be a secondary effect of activa-
tion of oxidative stress pathways [4, 28].
Conclusions
In our study, cardiac autonomic function appeared to be
altered in both a site dependent and a pollutant
dependent manner. Proximity to the steel plant was as-
sociated with significant reductions in HRV, and these
reductions appeared to be related to the elevated pollu-
tant concentrations at the Bayview site. Reductions in
HRV were consistent and statistically significant, and
they may provide a window into the mechanisms driving
the systemic effects of acute exposure to AP. Increased
sympathetic nervous system activity is associated with
reductions in HRV, such as those seen in our study, and
with increased systemic stress. Whether the autonomic
effects of site, or ambient pollution are a direct result of
pollutant exposure or whether they are secondary effects
of other systemic responses to AP, such as oxidative
stress, cannot be determined from this study; however it
is clear that exposure to ambient AP is associated with
altered autonomic function, and specifically elevated
sympathetic tone. Reduced HRV has been linked to in-
creased risk of cardiovascular mortality and morbidity in
vulnerable populations and has been shown to be pre-
dictive of all-cause mortality risk in healthy populations
[11, 12], and therefore may represent a mechanistic link
to the AP-mediated changes in risk of mortality and
morbidity, specifically cardiovascular mortality and mor-
bidity. Finally, it appears that we have found evidence of
a pattern of effects of AP exposure on the frequency do-
main of HRV in young healthy volunteers, which differs
from the pattern of effects reported in studies of vulner-
able populations.
Shutt et al. Environmental Health (2017) 16:4 Page 8 of 10
9. Additional files
Additional file 1: Table S1. Correlations between pollutants measured
in the Sault Ste Marie crossover study, irrespective of site. (DOCX 20 kb)
Additional file 2: Table S2. Associations between IQR increases in daily
maximum Air Quality Health Index and components of heart rate
variability. (DOCX 17 kb)
Abbreviations
AP: Air pollution; BMI: Body mass index; CO: Carbon monoxide; HF: High
frequency; HR: Heart rate; HRV: Heart rate variability; IQR: Interquartile range;
LF: Low frequency; N: Normal (sinoatrial node derived) beat; NO: Nitric oxide;
NO2: Nitrogen dioxide; NOX: Nitrogen oxides; O3: Ozone; PM2.5: Particulate
matter with an aerodynamic diameter of 2.5 μm or less; pNN50: Percent of
N-N intervals differing by more than 50 ms; PR: Pulse rate; RMSSD: Root mean
square of sucessive differences; SDNN: Standard deviation of N-N intervals;
SO2: Sulphur dioxide; UFP: Ultrafine particulate matter
Acknowledgements
This work was funded under Health Canada’s Clean Air Regulatory Agenda.
The authors would like to thank the Associates in Cardiology and the
University of Ottawa Heart Institute for their advice and expert analysis
of the holter data, with special thanks to JD Tompkins, Marie Mulholland, and
Dr Martin Green and Dr Darryl Davis. We are indebted to Nicolas Evans for his
extraordinary efforts to extract, merge, format and validate the HRV analysis
results. We wish to acknowledge the contributions of the team that
participated in planning, deployment, and data collection and analysis for the
Sault Ste Marie Crossover study as a whole, including: at Health Canada: Keith
Van Ryswyk, Hongyu You, Ryan Kulka, Marc Rigden, Kai Lei Ku, Josée Guénette,
Kevin Curtin, Erica Blais, Alain Filliatrault & Guillaume Pelletier; at the Ontario
Ministry of the Environment: Blair McLaughlin & Rod Stewart; at the Nordik
Institute, Algoma University: Gayle Broad, Stephanie Blaney & Ildiko Horvath.
Finally we wish to thank the study participants and the city and residents of
Sault Ste Marie.
Funding
The study presented in this manuscript was funded by Health Canada under
the Clean Air Regulatory Agenda, which mandates Health Canada to
investigate the effects of air pollution on the health of Canadians. The
manuscript was approved for submission by the Director of Environmental
Health Sciences Research Bureau at Health Canada. Health Canada retains
Crown Copyright.
Availability of data and materials
Due to the risk of re-identification, the databases containing health measures
and participant demographic information cannot be shared. Air pollution
data sets can be requested from the corresponding author. All data are
subject to Crown Copyright.
Authors’ contributions
RHS made a substantial contribution to the analysis and interpretation of the
data presented, and drafted and revised the manuscript. LMK made a substantial
contribution to HRV protocol development, data collection and analysis, as well
as manuscript revision. SW contributed to HRV protocol development,
experimental design, exposure data collection and manuscript revision.
RV contributed to project development and experimental design. PK &
EMT contributed to project development and experimental design, and
to manuscript revision. LL contributed to project development,
experimental design, analysis planning and manuscript drafting and
revision. MM made a substantial contribution to generation of
participant specific AP exposure data sets and contributed to the
analysis plan. SC led data analysis, and contributed to manuscript
drafting and revision. RD led project development and experimental
design, and contributed to analysis planning and manuscript drafting
and revision. All authors read and approved the final manuscript.
Competing interests
The authors declare that they have no competing interests.
Consent for publication
Not applicable. Data presented in this study are aggregate data, representing
mean and median responses from the entire study population.
Ethics approval and consent to participate
The study was approved by the Health Canada Research Ethics Board
(reference number 2009-0044) and the ethics board at Algoma University. All
participants completed in an ethics board approved informed consent process,
and were advised that they could refuse to participate in individual tests, or
withdraw from the study at any time, without penalty.
Author details
1
Population Studies Division, Environmental Health Science Research
Bureaum Health Canada, 50 Colombine Driveway, Ottawa, ON K1A 0 K9,
Canada. 2
Air Health Sciences Division, Water and Air Quality Bureau, Health
Canada, 269 Laurier Ave W, Ottawa, ON K1A 0 K9, Canada. 3
Mechanistic
Studies Division, Environmental Health Science Research Bureau, Health
Canada, 50 Colombine Driveway, Ottawa, ON K1A 0 K9, Canada. 4
Hazard
Identification Division, Environmental Health Science Research Bureau, Health
Canada, 50 Colombine Driveway, Ottawa, ON K1A 0 K9, Canada.
Received: 5 July 2016 Accepted: 3 December 2016
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