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ADULT RESPIRATORY DISTRESS SYNDROME (ARDS)
Non-cardiogenic pulmonary edema, also known as acute respiratory distress syndrome (ARDS), is characterized by severe arterial hypoxemia, bilateral alveolar infiltrates on chest imaging, and a normal left atrial pressure. It results from increased vascular permeability in the lungs leading to fluid accumulation in the alveoli and impaired gas exchange. The underlying pathophysiology involves diffuse damage to the alveolar-capillary membrane by various insults such as sepsis, infection, or injury. This disrupts the normal barrier function and leads to flooding of the lungs with protein-rich fluid.
Ards
ARDS is characterized by acute lung injury and hypoxemia. The document discusses definitions, pathophysiology, and treatment strategies for ARDS. Regarding treatment, the key principles are providing adequate gas exchange while minimizing ventilator-induced lung injury through gentle ventilation with low tidal volumes, optimal PEEP, and permissive hypercapnia. Additional strategies like prone positioning and inhaled nitric oxide may improve oxygenation, but their effects on long-term outcomes are unclear. Overall, ARDS carries a high mortality rate due to its association with multi-organ dysfunction syndrome.
Rob Mac Sweeney's FFICM Hot Topics Talk March 2016
Hot topics lecture given by Rob Mac Sweeney at the FFICM Preparation Course in London on March 9th 2016
Acute Lung Injury & ARDS
The document provides an overview of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), including definitions, risk factors, pathogenesis, management approaches, and results from major clinical trials. It discusses how lower tidal volume ventilation as tested in the ARDS Network trial was the first intervention shown to improve survival for patients with ALI/ARDS.
ARDS: An Evidence-based Update. By Mac Sweeney.
Rob mac Sweeney dissects the current evidence base that governs our diagnosis and management of ARDS. Distressing results.
Acute Respiratory Distress Syndrome
This document provides an overview of acute respiratory distress syndrome (ARDS). It defines ARDS and describes its three phases: exudative, proliferative, and fibrotic. ARDS is caused by lung injury from medical or surgical disorders and results in hypoxemia. Treatment focuses on treating the underlying cause, mechanical ventilation with low tidal volumes to prevent further lung injury, and maintaining a normal fluid balance to reduce pulmonary edema. While various adjunctive therapies have been investigated, supportive care remains the primary treatment approach.
subdural haematoma
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help boost feelings of calmness, happiness and focus.
Recommended
ADULT RESPIRATORY DISTRESS SYNDROME (ARDS)
Non-cardiogenic pulmonary edema, also known as acute respiratory distress syndrome (ARDS), is characterized by severe arterial hypoxemia, bilateral alveolar infiltrates on chest imaging, and a normal left atrial pressure. It results from increased vascular permeability in the lungs leading to fluid accumulation in the alveoli and impaired gas exchange. The underlying pathophysiology involves diffuse damage to the alveolar-capillary membrane by various insults such as sepsis, infection, or injury. This disrupts the normal barrier function and leads to flooding of the lungs with protein-rich fluid.
Ards
ARDS is characterized by acute lung injury and hypoxemia. The document discusses definitions, pathophysiology, and treatment strategies for ARDS. Regarding treatment, the key principles are providing adequate gas exchange while minimizing ventilator-induced lung injury through gentle ventilation with low tidal volumes, optimal PEEP, and permissive hypercapnia. Additional strategies like prone positioning and inhaled nitric oxide may improve oxygenation, but their effects on long-term outcomes are unclear. Overall, ARDS carries a high mortality rate due to its association with multi-organ dysfunction syndrome.
Rob Mac Sweeney's FFICM Hot Topics Talk March 2016
Hot topics lecture given by Rob Mac Sweeney at the FFICM Preparation Course in London on March 9th 2016
Acute Lung Injury & ARDS
The document provides an overview of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), including definitions, risk factors, pathogenesis, management approaches, and results from major clinical trials. It discusses how lower tidal volume ventilation as tested in the ARDS Network trial was the first intervention shown to improve survival for patients with ALI/ARDS.
ARDS: An Evidence-based Update. By Mac Sweeney.
Rob mac Sweeney dissects the current evidence base that governs our diagnosis and management of ARDS. Distressing results.
Acute Respiratory Distress Syndrome
This document provides an overview of acute respiratory distress syndrome (ARDS). It defines ARDS and describes its three phases: exudative, proliferative, and fibrotic. ARDS is caused by lung injury from medical or surgical disorders and results in hypoxemia. Treatment focuses on treating the underlying cause, mechanical ventilation with low tidal volumes to prevent further lung injury, and maintaining a normal fluid balance to reduce pulmonary edema. While various adjunctive therapies have been investigated, supportive care remains the primary treatment approach.
subdural haematoma
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help boost feelings of calmness, happiness and focus.
Splenomegaly with answers
There is an old splenic infarct seen as an area of low attenuation on CT scan without contrast. This area of low attenuation remains poorly visualized following intravenous contrast administration, consistent with an old splenic infarct. The splenic infarct appears as an area of low attenuation both before and after contrast administration.
ARDS w pneumothorax
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
Ct sah answer
The document describes a patient with enlarged ventricles due to hydrocephalus and a small aneurysm on a branch of the right middle cerebral artery. A 4x2mm saccular aneurysm was found on the M1 branch of the right middle cerebral artery in addition to prominent ventricles caused by hydrocephalus.
Case 1 answer
This document discusses portal venous gas seen on chest x-rays. Portal venous gas occurs when air enters the portal vein, usually due to necrosis of the stomach or gut wall, and is a very serious sign. It needs to be differentiated from pneumobilia, where air is in the bile ducts. Portal venous gas has a peripheral distribution of air in the liver, while pneumobilia is more centrally located. The document also mentions pneumatosis intestinalis, where air is found in the gut wall, which can indicate necrotizing enterocolitis or gut infarction.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Role of Mukta Pishti in the Management of Hyperthyroidism
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
A Classical Text Review on Basavarajeeyam
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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Top-Vitamin-Supplement-Brands-in-India List
Swisschem Dermacare provides the Top 10 Vitamin Supplement Brands in India. To know more about us give us call at our official number
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Do you have abnormal smell after periods? It may be vaginitis. Do not worry, herbal medicine Fuyan Pill can help you get a cure.
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Splenomegaly with answers
There is an old splenic infarct seen as an area of low attenuation on CT scan without contrast. This area of low attenuation remains poorly visualized following intravenous contrast administration, consistent with an old splenic infarct. The splenic infarct appears as an area of low attenuation both before and after contrast administration.
ARDS w pneumothorax
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
Ct sah answer
The document describes a patient with enlarged ventricles due to hydrocephalus and a small aneurysm on a branch of the right middle cerebral artery. A 4x2mm saccular aneurysm was found on the M1 branch of the right middle cerebral artery in addition to prominent ventricles caused by hydrocephalus.
Case 1 answer
This document discusses portal venous gas seen on chest x-rays. Portal venous gas occurs when air enters the portal vein, usually due to necrosis of the stomach or gut wall, and is a very serious sign. It needs to be differentiated from pneumobilia, where air is in the bile ducts. Portal venous gas has a peripheral distribution of air in the liver, while pneumobilia is more centrally located. The document also mentions pneumatosis intestinalis, where air is found in the gut wall, which can indicate necrotizing enterocolitis or gut infarction.
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Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Role of Mukta Pishti in the Management of Hyperthyroidism
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
A Classical Text Review on Basavarajeeyam
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
share - Lions, tigers, AI and health misinformation, oh my!.pptx
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Top-Vitamin-Supplement-Brands-in-India List
Swisschem Dermacare provides the Top 10 Vitamin Supplement Brands in India. To know more about us give us call at our official number
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Efficacy of Avartana Sneha in Ayurveda
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