Regional anesthesia and acute pain medicine billing is complex, with multiple factors to consider in determining the correct codes. Procedures may be billed as anesthesia with time units, procedural codes, or follow-up care. The purpose of the block, type of surgical anesthesia, and whether the block is separately reportable affect billing. Documentation of medical necessity, requests, and ultrasound use is important. Non-procedural acute pain service is usually billed under evaluation and management codes with caveats for epidural follow-up and inpatient billing.