2. OVERVIEW
• Magnitude of Problem
• Causes
• Cardiopulmonary Causes
- Cardiac
- Vascular
- Pulmonary
• Non Cardiopulmonary Causes
- Gastrointestinal
- Neuromuscular
- Others
• Approach
• Investigations
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3. Epidemiology
• After injuries, chest pain is the second most common reason for adults to present
to the ER In US.
• >6.5 million visits to ER and 4 million visits to OPD
• The lifetime prevalence of chest pain in the United States is 20% to 40% .
• Of all ED patients with chest pain, only 5.1% will have ACS.
• CAD affects >18.2 million adults in the US and remains the leading cause of
death for men and women, accounting for >365,000 deaths annually.
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4. MAGNITUDE OF PROBLEM
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• Only 15-20 % of patients presenting with chest pain actually have
Acute Coronary Syndrome (ACS).
10 % present with life-threatening non cardiac chest pain
• MC Cause- Gastrointestinal
• Triage of patients should be done like:
1. Myocardial Ischemia
2. Other Cardiopulmonary Causes
3. Non- Cardiopulmonary Causes
• 2-6 % of patients with chest discomfort due to Ischemic causes are
missed and later present with Myocardial Infarction.
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5. DefiningChestPain
Chest pain refers to many unpleasant or uncomfortable sensations in the anterior chest.
Patients often report pressure, tightness, squeezing, heaviness, or burning.
Locations other than the chest, including the shoulder, arm, neck, back, upper
abdomen, or jaw .
COR LOE Recommendations
1 B-NR
1. An initial assessmentof chest painis recommendedto triage patientseffectivelyon the basis
of the likelihood that symptomsmaybe attributable to myocardialischemia.
1 C-LD
2. Chest painshouldnot be described as atypical,becauseit is not helpfulin determining the
cause and can be misinterpreted as benign in nature. Instead,chest painshouldbe described as
cardiac,possibly cardiac, ornoncardiac because these termsare more specific to the potential
underlying diagnosis.
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11. APPROACH
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• Quick History
• Physical Examination
• Stability – R/O
• High risk conditons:
- ACS
- Acute Aortic Syndrome
- Pulmonary Embolism
- Tension Pneumothorax
- Pericarditis with
tamponade
- Esophageal Rupture
• Investigation
• Ecg, biomarkers
• Immediate intervention
and further diagnostic
and therapeutic
interventions
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12. Diagnostic approach
• Clinical stability------------------stable vs unstable
• Immediate prognosis------------------good or poor
• Safety of triage options-------------------discharge or further investigate
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13. HISTORY
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If stable do assess
• Quality of pain
• Location
• Radiation
• Pattern
• Agrravating & Relieving Factors
• Associated Symptoms
• Past Medical History
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14. Chest PainCharacteristics and CorrespondingCauses
Nature
Anginal symptoms are perceived as retrosternal chest discomfort (e.g., pain, discomfort,
heaviness, tightness, pressure, constriction, squeezing
Sharp chest pain that increases with inspiration and lying supine is unlikely
related to ischemic heart disease (e.g., these symptoms usually occur with acute
pericarditis).
Onset and duration
Anginal symptoms gradually build in intensity over a few minutes.
Sudden onset of ripping chest pain (with radiation to the upper or lower back) is unlikely to
be anginal and is suspicious of an acute aortic syndrome.
Fleeting chest pain—of few seconds’duration—is unlikely to be related to ischemic heart
disease.
Location and radiation
Pain that can be localized to a very limited area and pain radiating to below the umbilicus or
hip are unlikely related to myocardial ischemia.
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15. Severity
Ripping chest pain (“worse chest pain of my life”), especially when sudden in onset and occurring
in a hypertensive patient, or with a known bicuspid aortic valve or aortic dilation, is suspicious of an
acute aortic syndrome (e.g., aortic dissection).
Precipitating factors
Exertion, emotional, meal, rest .
Positional chest pain is usually nonischemic
Relieving factors
resting and nitroglycerin is not necessarily diagnostic of myocardial ischemia and should not be used as
a diagnostic criterion.
Associated symptoms
Common symptoms associated with myocardial ischemia include, but are not limited to, dyspnea,
palpitations, diaphoresis, lightheadedness, presyncope or syncope, upper abdominal pain, or heartburn
unrelated to meals and nausea or vomiting.
Symptoms on the left or right side of the chest, stabbing, sharp pain, or discomfort in the throat or
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17. PHYSICAL EXAMINATION
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• Vitals always the first
• Initial examinations focusing early finding of clue of potential
life-threatening condition or potential precipitating factors of
ischemia
• COPD
• CHF
• Cardiac tamponade
• R/O aortic dissection, pneumothorax
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18. Clinical Syndrome Findings
Emergency
ACS Diaphoresis, tachypnea, tachycardia, hypotension, crackles, S3,
MR
murmur; examination may be normal in uncomplicated cases
PE Tachycardia + dyspnea—>90% of patients; pain with inspiration
Aortic dissection Connective tissue disorders (e.g., Marfan syndrome), extremity
pulse
differential (30% of patients, typeA>B)
Severe pain, abrupt onset + pulse differential + widened
mediastinum on CXR >80% probability of dissection
Frequency of syncope >10% (8), AR 40%–75% (typeA)
Esophageal
rupture
Emesis, subcutaneous emphysema, pneumothorax (20%
patients),
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19. Other
Noncoronary cardiac:
AS, AR,
HCM
AS: Characteristic systolic murmur, tardus or parvus carotid
pulse
AR: Diastolic murmur at right of sternum, rapid carotid upstroke
HCM: Increased or displaced left ventricular impulse,
prominent a wave in jugular venous pressure, systolic murmur
Pericarditis
Myocarditis
Fever, pleuritic chest pain, increased in supine position, friction
rub
Fever, chest pain, heart failure, S3
Pneumonia Fever, localized chest pain, may be pleuritic, friction rub may be
present, regional
dullness to percussion, egophony
Pneumothorax Dyspnea and pain on inspiration, unilateral absence of breath
sounds
Costochondritis, Tietze
syndrome
Tenderness of costochondral joints
Herpes zoster Pain in dermatomal distribution, triggered by touch;
characteristic rash (unilateral
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20. INVESTIGATIONS
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• ECG--------early ECG saves time and increase probability of catching ACS
• CXR------------done for all patients can show pneumonia, pulmonary edema, pleural effusion
Pneumothorax may show rare features of PTE can show mediastinal dilation in AD
• Cardiac Biomarkers-----cardiac troponin T and I are proffered
• Provocative Testing
• Other Noninvasive Tests
- Echocardiography
- CT Angiography
- MRI
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21. Risk stratification
• Clinical decision pathways stratify patients in to categories to estimate
1. Probability of AMI
2. Risk of 30 day MACE
• Accordingly, patients are grouped in to Low, intermediate and High
risk groups by using
• Symptoms
• CAD risk factors
• ECG
• Biomarkers
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22. Introduction
Pulmonary embolus (PE) refers to obstruction of the pulmonary artery or one
of its branches by material
PE can be classified by the following:
The temporal pattern of presentation (acute, subacute, or chronic)
The presence or absence of hemodynamic stability (hemodynamically unstable or
stable)
The presence or absence of symptoms (symptomatic or asymptomatic)
The anatomic location (saddle, lobar, segmental, subsegmental)
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24. Classification of acute PE can assist with prognostication and
clinical management.
Massive PE accounts for 5% to 10% of cases.
Submassive PE is more common, occurring in approximately 20%
to 25% of patients.
Low-risk PE constitutes the majority of PE cases—approximately
70%.
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Classification of PE…
25. HX and P/E
Investigation including routine lab.
Imaging
The most useful approach is :
a clinical assessment of likelihood, based on presenting symptoms and
signs,
in conjunction with judicious diagnostic testing.
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Diagnosis of PE
26. Symptoms
Unexplained dyspnea
Chest pain, especially pleuritic or
“positional”
Anxiety
Cough
Signs
Tachypnea
Tachycardia
Low-grade fever
signs of right heart failure
Hemoptysis
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Diagnosis
27. PE should be suspected in hypotensive patients when there is evidence of
Venous thrombosis or predisposing VTE risk factors;
Acute cor pulmonale (acute right ventricular failure)
Echocardiographic findings of RV dilation and hypokinesis or
ECG evidence of acute cor pulmonale manifested by
A new S1Q3T3 pattern,
A new right bundle branch block, or
RV ischemia manifested by inferior T wave inversion or T wave inversion in leads V1
through V4.
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Diagnosis…
28. Wells criteria include :
Clinical symptoms of deep vein
thrombosis (DVT) (3 points)
Other diagnoses are less likely than PE
(3 points)
Heart rate >100 (1.5 points)
Immobilization three or more days or
surgery in previous four weeks (1.5
points)
Previous DVT/PE (1.5 points)
probability of PE into a three-tiered
system
Low (score <2)
Intermediate (score 2 -6)
High (score >6)
can also be used to classify patients
into a two-tiered system:
patients are likely (score >4) or
unlikely (score ≤4) to have PE
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Diagnosis…
31. Diagnosis
• Role of D-dimer
• Is no specific marker used for less likelihood pateints
• Role of echo
• Ruling out mimics eg ACS and pericardial diseases
• rapid, practical, and sensitive technique for detection of right ventricular overload
among patients with established and large PE.
• CTPA diagnostic modality of choice
• Pulmonary angiography rarely used
• V/Q mismatch alternative
•
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33. Treatment
• primary therapy --------------------
• For patents with massive PE and hemodynamically unstable For
submissive or stable patients anticoagulant is preferred
• Secondary therapy
• For hemodynamically stable patients
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35. POST-RESUSCITATION
Do the diagnostic evaluation quickly:
• If no PE, stop anticoagulant therapy
• If PE, continue therapy .
Primary Therapy versus Secondary Prevention
Primary therapy: consists of thrombolysis or embolectomy
Secondary prevention: heparin and warfarin or IVC filter for prevention
of recurrent PE
DOAC and NOAC
38. Initial goals of therapy are to:
Quickly identify via 12-lead ECG whether patient has ST elevation and
therefore is a candidate for immediate reperfusion therapy
Relieve pain
Prevent/treat arrhythmias and mechanical complications
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39. Diagnosis
• Serial ECG
• Cardiac markers
• Initiate emergency care
• Echocardiography
• Coronary angiography
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40. Medical Management
General measures
Oxygen- for Spo2<90% or RD
activity
Diet
Bowel management
Sedation
Chest discomfort
Analgesics- Morphine- 4-8 mg IV, then 2-8 mg q 5-15 minutes
Anti-ischemic medications- Nitrates and BB
Antithrombotic therapy
anti platelets
Anticoagulants
Others
Statins , RAAS inhibitors , CCBs ,MRA 40
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42. PCI Vs CABG
PCI
Faster revascularization
A lower risk of stroke
Absence of deleterious effects of
cardiopulmonary bypass on the ischemic
myocardium
DES Preferred
CABG
• Disease of the left main coronary artery (LMA)
• MVD with
• LVEF < 40% and/or
• DM
• Contraindication to DAPT
• Need for concomitant Cardiovascular surgery
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43. NSTE-ACS
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• Patients with NSTE-ACS should be treated with an early medical
regimen similar to that used in STEMI with one exception:
• There is no evidence of benefit (and possible harm) from
fibrinolysis
• Early risk assessment is useful in identifying patients who would
derive the greatest benefit from an early invasive strategy
44. Risk Stratification
Integrate patient characteristics
Prognosis and optimal care
TIMI risk score
http://www.mdcalc.com/timi-risk-score-for-stemi
GRACE risk model
http://www.outcomes-
umassmed.org/grace/acs_risk/acs_risk_content.html
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45. 4/2/2024
•TIMI risk scores from 0 to 2
(low risk) to 5 to 7 (high risk)
•only patients at moderate to
high risk (score ≥3)
benefited from an early
invasive strategy
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Paradoxical Embolism
may manifest with a sudden stroke, which may be misdiagnosed as “cryptogenic.”
The cause is a DVT that embolizes to the arterial system, usually through a patent foramen ovale.
The DVT can be small and break away completely from a tiny leg vein
Nonthrombotic PE
Sources of embolism other than thrombus are uncommon: fat, tumor, air, and amniotic fluid.
Fat embolism most often occurs after blunt trauma complicated by long bone fractures.
Air embolus can occur during placement or removal of a central venous catheter.
Amniotic fluid embolism may be catastrophic and is characterized by respiratory failure, cardiogenic shock, and disseminated intravascular coagulation.
Symptoms and signs of PE are nonspecific.
clinical suspicion for PE is of paramount importance in guiding diagnostic testing.
Dyspnea is the most frequent symptom, and
tachypnea is the most frequent sign of PE
Severe dyspnea, syncope, or cyanosis portends a major life-threatening PE, in which the clinical picture often is devoid of chest pain.
Paradoxically, severe pleuritic pain often signifies that the embolism is small, not life-threatening, and located in the distal pulmonary arterial system, near the pleural lining
Drug- eluting stent
The choice of revascularization procedure after angiography depends upon the location and extent of disease. Among patients with an appropriate lesion, PCI is most often performed, but CABG is usually preferred for the treatment of patients with left main or left main equivalent disease, or three- or two-vessel disease involving the left anterior descending artery with left ventricular dysfunction or treated diabetes
Waiting period of 3–7 days may be the best compromise (at least 3 days following interruption of ticagrelor, 5 days for clopidogrel, and 7 days for prasugrel), while it is recommended that aspirin is continued. The first aspirin administration post-CABG is recommended 6–24 h after surgery in the absence of ongoing bleeding events
We use the in-hospital mortality outcome with the GRACE score. It helps us determine disposition in our STEMI patients; those with a score of 130 or higher go to the ICU after catheterization, and those with lower scores can go to our step down unit.
All STEMI patients should undergo risk assessment within the first four to six hours of hospitalization.
The GRACE registry, a global registry of ACS patients from 94 hospitals in 14 countries, developed two models to estimate the risk of in-hospital and six-month mortality among all patients with an ACS, an end point different from the composite end point in the TIMI risk score.
A higher TIMI risk score correlated significantly with increased numbers of events (all-cause mortality, new or recurrent MI, or severe recurrent ischemia requiring revascularization) at 14 days (calculator 1):
●Score of 0/1 – 4.7 percent
●Score of 2 – 8.3 percent
●Score of 3 – 13.2 percent
●Score of 4 – 19.9 percent
●Score of 5 – 26.2 percent
●Score of 6/7 – 40.9 percent