u

1. https://medlineplus.gov/genetics/gene/lmnb1/#resources
Dittmer TA, Misteli T. 2011. The lamin protein family. Genome Biol 12:222-222.
Lamin B1 is an intermediate filament protein which is a form of structural protein. The role
of intermediate filaments is to maintain cell stability and offers strength. The lamins were
first characterized biochemically as prominent 60 to 80 kDa proteins of the nuclear lamina
and eventually identified as intermediate filament (IF) proteins by sequence homology [1-6].
The name intermediate filament refers to the average diameter of assembled intermediate
fibers (10 to 12 nm), which is between that of actin microfilaments (7 to 10 nm) and that of
microtubules (25 nm)
Lamin B1 is a scaffolding (supporting) component of the nuclear envelope, which is the
structure that surrounds the nucleus in cells. As part of the nuclear envelope, lamin B1 helps
regulate the movement of molecules into and out of the nucleus. The protein also plays a role
in the copying (replication) of DNA in preparation for cell division and the activity
(expression) of many genes by being involved in the organization of chromosomes within the
nucleus.
Resource: https://medlineplus.gov/genetics/gene/lmnb1/#resources
Dittmer TA, Misteli T. 2011. The lamin protein family. Genome Biol 12:222-222.