The document discusses improving efficacy and safety in IVF and ICSI cycles. It recommends using an antagonist protocol rather than an agonist protocol to reduce complications like ovarian hyperstimulation syndrome (OHSS) while maintaining efficacy. The antagonist protocol is associated with shorter treatment duration, fewer stimulation days, lower gonadotropin amounts, and no ovarian cysts or hot flashes. Studies show the antagonist protocol is safer than the agonist protocol for IVF and ICSI cycles.

1. ‫الرحيم‬ ‫الرمحن‬ ‫هللا‬ ‫بسم‬
ANTAGONIST PROTOCOL

7. In IVF & ICSI Cycle, We Need
Improve Efficacy Better results
PREGNANCY
Improve Safety Less
Complications
OHSS

8. Ovarian Hyperstimulation Syndrome
The Most SERIOUS Complication Of
IVF& ICSI, SO
(SAFETY COME FIRST)

9. We Should Be Evidence Based

10. ESHRE, OCTOBER 2019

11. ESHRE, OCTOBER 2019

12. ESHRE, OCTOBER 2019

13. ESHRE, OCTOBER 2019

22. WHY ANTAGONIST ???
1-Shorter duration of GnRH analogue treatment
2-Less days of stimulation .
3-Reduction in the amount of gonadotropins .
4-No Ovarian cyst Or Hot flashes
5-Can exclude early pregnancy

23. Our Final Conclusion
- No significant difference in the Efficacy of
GnRH antagonist and Long agonist .
-GnRH antagonist Protocol is saferthan
GnRh agonist in IVF & ICSI cycle .

24. Now, WOULD YOU CAHANG YOUR PROTOCOL
FROM AGONIST TO ANTAGONIST ?
Simple, Shorter and SAFER

25. But Not all Doctors will go
to ANTAGONIST !!!!

26. DR.
Ahmed Refaat Adly
Specialist of Reproductive Medicine and Surgery