Andrew Powrie Smith Breakdowns V2
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ABPIThe document contains a survey asking respondents about their views on the pharmaceutical industry's role in supporting continuous medical education, international congresses, non-accredited medical education and meetings, and transparency around payments to healthcare professionals. The survey asks respondents to indicate what sector and job function they represent, and to provide opinions on different models of support the industry could adopt.
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Running head: MARKETING 1
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To effectively market the new product, it is essential to do SWOT analysis. It is importan to identify the strength, weaknesses, opportunities and threats of the food products.
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The organization will concentration its marketing efforts on customers that live in the Colorado area. The median income of people who live in this area is $72,000. The median age of people that live in this area is 39 years old. Majority of people living in this area are married and well educated with a flexible career, (Graham, 2018). The target population are not committed to a healthy lifestyle. However, they spend money on high-quality products and luxurious products. The number of people that live in this area is 80206.
For human being and pets to survive, they have to eat. The new pet food products fulfil the needs and want of the target market by offering health, and sustainable food that replicates their lifestyle habit. The target population is willing to spend some extra cash on high-quality products. The product satisfies more than just the need of the target market by ensuring that the desires of having an active and energetic pet are met.
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This document discusses the need for a new vision for healthcare organizations and how organizational behaviors can affect physician professionalism. It notes how non-profit organizations influence physician behaviors and provides examples like conflicts of interest. A new vision is critical now due to goals of improving care quality while lowering costs. The document proposes core values for healthcare organizations like beneficence, dignity, and justice, along with competencies and behaviors to demonstrate those values. Leaders must integrate professional values into all operations and ensure organizational culture supports those values.
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The document discusses marketing strategies for accounting firms, including how to create a brand, position themselves in the market, and change negative perceptions. It provides examples of branding tools like surveys, websites, blogs, and brochures that firms can use. It also discusses developing a marketing plan with strategies, tactics, and following rules of positioning to focus on one clear message that differentiates the firm. Case studies are presented on how Alfred Nobel changed the perception of dynamite through establishing the Nobel Prizes after being criticized for his invention.
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The panel discusses opportunities and challenges for healthcare improvement and value in emerging Asia-Pacific markets. While an emerging middle class and shift to chronic diseases present opportunities, most countries have limited healthcare funding and infrastructure. Governments are reforming systems but face pressure to control costs. Some countries like Korea and Taiwan have adopted health technology assessment (HTA) to balance innovation and resources, but others lack expertise and data for HTA. European examples demonstrate the long-term benefits of balancing cost containment and industrial policy, with HTA integrated over time to improve efficiencies and avoid unintended consequences of short-term measures.
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Acne is a common skin condition that occurs when hair follicles become clogged with oil and dead skin cells. It typically manifests as pimples, blackheads, or whiteheads, often on the face, chest, shoulders, or back. Acne can range from mild to severe and may cause emotional distress and scarring in some cases.
**Causes:**
1. **Excess Oil Production:** Hormonal changes during adolescence or certain times in adulthood can increase sebum (oil) production, leading to clogged pores.
2. **Clogged Pores:** When dead skin cells and oil block hair follicles, bacteria (usually Propionibacterium acnes) can thrive, causing inflammation and acne lesions.
3. **Hormonal Factors:** Fluctuations in hormone levels, such as during puberty, menstrual cycles, pregnancy, or certain medical conditions, can contribute to acne.
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**Types of Acne:**
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- **Blackheads:** Open plugged pores with a dark surface.
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- **Nodules:** Large, solid, painful lumps beneath the surface.
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Treatment depends on the severity and type of acne but may include:
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- **Oral Medications:** Antibiotics or oral contraceptives for hormonal acne.
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**Prevention and Management:**
- **Cleanse:** Regularly wash skin with a gentle cleanser.
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Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
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Endocrine Therapy
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Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
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PGx Analysis in VarSeq: A User’s Perspective
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
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Andrew Powrie Smith Breakdowns V2
- 1. Trust Imperative Trust: to be a trusted partner in the healthcare system
- 4. By Job Function Please indicate which sector you represent
Editor's Notes
- Andrew Powrie-Smith 11.00am – 11.20am Welcome Housekeeping Rules of the day Introductions