Amphipathic means that the molecule has a polar, hydrophillic end and a non-polar hydrophobic end. In water, amphipathic molecules tend to form micelles, with the hydrophillic ends outward and the hydrophobic ends inward. Solution Amphipathic means that the molecule has a polar, hydrophillic end and a non-polar hydrophobic end. In water, amphipathic molecules tend to form micelles, with the hydrophillic ends outward and the hydrophobic ends inward..