Amino acids -- treatment for chronic pain

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Timeline ,[object Object],[object Object],[object Object],Sep 28, 1969 Murchison Meteorite Sep 28, 1969 Timeline

Timeline ,[object Object],[object Object],[object Object],Year 2006 MacLeod’s Lab Year 2006 Sep 28, 1969 Timeline

Why study amino acids? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Betz & Laube 2006

Isovaline & ACBC – analogues of glycine & GABA ,[object Object],[object Object],[object Object],[object Object]

Timeline ,[object Object],[object Object],[object Object],Present Project Goals Present Timeline Year 2006 Sep 28, 1969

Osteoarthritis (OA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

3 part study ,[object Object],[object Object],[object Object]

1. Maximum tolerated dose ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1. MTD study – Method & Protocol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1. MTD study - Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1. MTD study – An anecdote Rat 6, 2000mg/kg racemic isovaline

2. Dose ranging studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

2. DR Studies – Up & down method ,[object Object],( - ) ( - ) ( - ) ( + ) ( + ) ED50 Est. range of ED50 Dose 1 Dose 2 Dose 3 Dose 4 Dose 5

2. DR studies - Formalin foot test -5 drug TIME (min) formalin 20 5 10 15 25 35 40 30 -20 Acclimatization

2. DR studies - Results ,[object Object],[object Object],[object Object],Finding ED 50 for inhibition of phrase II formalin foot paw licking response using the “up and down” method

3. Osteoarthritis model ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

3. OA model - Protocol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

3. OA model - Induction of osteoarthritis ,[object Object],[object Object],[object Object],[object Object]

OA Model – Objective evaluation of pain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

OA model – Allodynia test ,[object Object],[object Object],[object Object],[object Object],[object Object]

OA model - Effects of conventional analgesics Fernihough et al. 2004

OA model – Preliminary data ,[object Object],[object Object]

Take home messages ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The Hugill Centre for Anaesthesia & Analgesia University Graduate Fellowship

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