This document discusses the role of altered fractionation in treating head and neck carcinomas. It begins by providing background on head and neck cancers, noting they are the 6th most common cancer worldwide. It then discusses general management guidelines, focusing on using the treatment modality with the highest chance of cure. Patterns of failure are also reviewed. The bulk of the document then examines different fractionation schedules, including conventional fractionation as well as hyperfractionation and accelerated fractionation. Several studies are summarized that demonstrate improved local tumor control and survival with these altered fractionation approaches compared to conventional fractionation. The document concludes by discussing hypofractionation and future directions incorporating improved radiobiology knowledge and biological response modifiers.