The document summarizes a sales meeting focused on taxane-related products, noting that taxanes require significant engineering for their formulation and that drugs like docetaxel and vinorelbine will become off-patent in the near future, presenting an opportunity. It provides details on companies developing lipid-soluble taxane products and clinical trials underway, and highlights a recent investigational new drug application filed for a novel liposomal docetaxel delivery system.

1. Sales Meeting – Western Region – January 14 2008
Focus: Taxane Related Products

2. Why pursue Taxane based products?
“This places screams engineering – engineering is your strong point” - Doug Johnson, Allos:

3. Why pursue Taxane based products?
Taxane based products require large amounts of engineering
• Combination of aqueous & lipid phases
• Homogenization
• Microfluidization
• Possible cytotoxic lyophilization?

4. Why pursue Taxane based products?
Docetaxel to expire 2010
Vinorelbine – off-patent since 2003

5. Lipid-Soluble API Formulation
SN-38
NeoPharm, Inc.
Enzon Pharmaceuticals, Inc
Taxanes
RTI, International
Cell Therapeutics, Inc.
Azaya Therapeutics

6. Small to Mid-Pharma with Ongoing Clinical Trials
Docetaxel
RTI, International Novacea
Cell Therapeutics, Inc. Zeneus Pharma
Azaya Therapeutics Genta Incorporated
MethylGene Poniard Pharmaceuticals
Ascenta Therapeutics Seattle Genetics, Inc.
Cell Genesys GPC Biotech
Titan Pharmaceuticals Proacta, Incorporated
Cytogen Corporation Keryx Biopharmaceuticals
Tibotec Therapeutics Infinity Pharmaceuticals, Inc.
ONYX Pharmaceuticals Cytokinetics, Inc.
AmpliMed Corporation Semafore Pharmaceuticals Inc.
CPT-11
EMD Serono, Inc. Celgene Corporation
Wellstat Therapeutics YM BioSciences
Adnexus Dynavax Technologies Corporation
ImClone Systems

7. Why pursue Taxane based products?
Taxane based products require large amounts of engineering
• Combination of aqueous & lipid phases
• Homogenization
• Microfluidization
• Possible cytotoxic lyophilization?

8. How widespread are Taxane based products How widespread are
Taxane based products?
Docetaxel
Docetaxel- 809 on-going studies
Vinorelbine- 160 on-going studies
CPT-11- 210 on-going studies
SN-38- 13 on-going studies

9. Recent News
Docetaxel
02 Jan 2008 NEOPHARM, Inc. today announced that it has filed an investigational new drug
application with the FDA for a novel, proprietary liposomal delivery system of docetaxel, the
active ingredient of Taxotere(R) (docetaxel), for the treatment of patients with locally advanced or
metastatic solid tumor after failure of prior chemotherapy
WAUKEGAN, IL, USA | January 2, 2008 | NEOPHARM, Inc. (NASDAQ:NEOL) today announced
that it has filed an investigational new drug application (IND) with the U.S. Food and Drug
Administration (FDA) for a novel, proprietary liposomal delivery system of docetaxel, the active
ingredient of Taxotere(R) (docetaxel), for the treatment of patients with locally advanced or
metastatic solid tumor after failure of prior chemotherapy.

10. “Promote it and they will come”
HCM to Paperazzi Current HCM Client to closest CMO
Distance 700 ft Distance 500 ft