The Avahan-India AIDS Initiative is a comprehensive HIV prevention program launched in 2003, focusing on high-risk populations in six Indian states, which account for the majority of HIV infections. With significant funding from the Bill & Melinda Gates Foundation, the program emphasizes peer-led outreach, data-driven management, and community mobilization to effectively deliver prevention services. Avahan's successful combination of behavioral, biomedical, and structural interventions has positioned it as a global model for addressing concentrated HIV epidemics.