1. Definition
• "Aerosol is a pressurized dosage forms
containing one or more therapeutic active
ingredients which upon actuation emit a fine
dispersion of liquid and/or solid materials in a
gaseous medium“
• solid particles or liquid droplets constitute the
disperse phase and gas in the continuous phase
• A system that depends on the power of a
compressed or liquefied gas (propellants);
container; valve assembly to expel the contents
from the container
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30. Valves
1. Easy to open and close
2. Capable of delivering the content in the
desired form such as spray, foam, solid
stream etc.
3. It can deliver a given amount of medicament
48. SOLUTION SYSTEM
• Propellant 12 is used generally in formulation
of this system, because it helps in producing
very fine particles.
49.
50.
51.
52.
53.
54.
55. SUSPENSION SYSTEM
• After the formation of suspension system, some
particles show a tendency to aggregate due to
solubility, moisture or particle size growth.
• When large agglomerates are formed then it
leads to caking, & at higher temp. there is an
increase in the rate of Agglomeration, which
leads to flocculation.
• These particles stick to the wall of the container,
leading to valve clogging resulting improper
dosage & the particles also damage the metal
container.
72. Me
thods
Method A
• Product concentrate chilled to -30 to -40o F.
• Chilled product added to chilled container.
• Chilled propellant added through inlet valve.
Method B
• Product concentrate and propellant chilled to -30 to -40o F.
• Mixture added to chilled container.
12/23/2020 90
73. • The valves are set in place.
• Filled containers passed through water bath (contents
heated to 130o F).
• Containers dried, capped and labeled.
Advantage
• Easy process
Disadvantages
• Aqueous products, emulsions cannot be filled.
• For non aqueous systems, moisture appears in final
product.
12/23/2020 91
