SlideShare a Scribd company logo
Scenario One
WHILE WORKING IN THE ED, A 45-YEAR-OLD MALE PRESENTS WITH ABDOMINAL PAIN.
HE DESCRIBES THE ABDOMINAL PAIN AS “SEVERE” AND GRADED IT A 7/10. THERE’S BEEN ASSOCIATED
EPISODES OF NAUSEA AND VOMITING.
HE MENTIONS THE PAIN RADIATED TO THE BACK BUT GETS BETTER WHEN HE LEANS FORWARD. HE HAD
JUST RETURNED FROM A PARTY THE NIGHT BEFORE WHERE HE HAD CONSUMED QUITE A LOT OF LAGERS.
ON EXAMINATION, THERE WAS EPIGASTRIC TENDERNESS, AND A PURPLE DISCOLORATION AROUND THE
PERIUMBILICAL REGION.
Scenario Two
 While in the ED, a 50-year-old female presents with sudden onset abdominal pain. She mentions
she felt warm to touch and her partner had noticed her eyes looked a bit yellow.
 She had taken paracetamol to help with the pain, but it wasn’t helping. She explained that the pain
seemed to be worse after eating meals.
 On examination, there was epigastric pain, radiating to the back, sclerus icterus, and a temperature
of 37.9
Acute Pancreatitis
By Dr. Gboneme Sandra
Junior Clinical Fellow in Medicine
George Eliot NHS Trust
Outline
 Introduction
 Theory
 Etiology
 History and Exam
 Investigations
 Criteria
 Treatment options
 Differentials
 Summary
 Questions ?
Introduction
 Acute Pancreatitis is an acute inflammation and hemorrhaging of the pancreas due to its own
digestive enzymes.
 It is a common cause of acute abdominal pain .
 Grouped into Mild, Moderate, Severe
 Mild: No systemic complications , or organ involvement
 Moderate; associated systemic complications or transient organ failure, resolves in 48 hours .
 Severe: resolves in greater than 48 hours.
Theory
 Pancreas is located retroperitoneally in the epigastric region.
 Pancreas plays both endocrine and exocrine role;
 Exocrine role: Acinar cells produce digestive enzymes that help digest food
 The pancreas protects itself by producing enzymes in their inactive form
 These enzymes are called zymogens/tripsinogen and are kept in zymogen granules.
 Usually, zymogens are activated by Proteases.
Etiology
Alcohol misuse
Gallstone migration
Middle aged women
Young to middle aged men
Hypertriglycerides
Use of causative drugs
Trauma
Hypercalcemia
Mumps
Family history of pancreatitis
Autoimmune Conditions
Pancreatic Cancer
History and Examination
 Mid-Epigastric Pain or Left upper quadrant
pain radiating to the back
 Nausea and Vomiting
 Signs of hypovolemia ( decreased skin turgor,
hypotension, oliguria)
 Signs of pleural effusion 9especially due to
pulmonary dysfunction)
 Anorexia/ Lack of appetite
 ABDOMINAL EXAM: Tender abdomen with
voluntary guarding
 Signs of SIRS: Tachypnoea, tachycardia,
temperature spikes
 Jaundice
 Cullen’s/Grey turner sign
Investigations
 SERUM TRYPSIN: Most accurate but not routinely available
 LIPASE
 AMYLASE
 ROUTINE BLOODS; FBC, U and E, LFT, CRP
 Calcium: Hypercalcemia and Hypocalcemia
 Serum Triglycerides ( if not gallstone or alcohol ) consider if >11.3 mmol
 IMAGING; Contrast Enhanced CT Abdo ( not necessary for diagnosis)
Bedside Index of Severity in Acute Pancreatitis
(BISAP) Score
 BUN > 8.9mmol/L (1 point)
 Abnormal mental status with a GCS of <15 (1 point)
 Evidence of SIRS (1 point )
 Patient age > 60 years old ( 1 point)
 Imaging Study reveals pleural effusion ( 1 point )
 0 to 2 points: Lower Mortality
 3 to 5 points: Higher Mortality
APACHE II
Treatment
 ABC of Resuscitation
 FLUID RESUSCITATION
 Pain control
 Antiemetic
 Alcohol related: Replace Thiamine and other vitamins
 Antibiotics if infection is implicated
 Early nutritional support, parenteral if neccessary
Differentials
 PUD
 Intestinal obstruction
 Cholecystitis
 Hepatitis
Summary
 In Summary, Acute pancreatitis is a common presentation in
the ED, and is one that should not be missed.
 It requires a high index of suspicion with alcohol and
gallstones being the most common causes .
 With regards to investigations; Serum Lipase/Amylase is the
key investigation and tends to be 3x the higher normal
 Fluid resuscitation is important, as well as pain control.
Scenario three
 A 60-year-old man comes to the emergency complaining of severe epigastric abdominal pain that
radiates to the back. Pain improves when he leans forward. It is worse when he breathes in deeply.
He also complains of nausea, vomiting and loss of appetite. He smokes 10 cigarettes and drinks 14
units of alcohol per day.
 On examination, he has tachycardia, tachypnoea and low blood pressure. There are decreased
breath sounds over the base of his left lung.
 His routine Bloods showed: BUN 9.9mmol, WBC; 14,000, CRP: 117, Neut: 11,000, adjusted calcium:
2.0
 What is his BISAP score ?
 What extra tests would you request?
 What management would you recommend ?
Questions?
Thank you very much.

More Related Content

Similar to acutepancreatitis-231026214130-e9413a87.pdf

Pancreatitis
PancreatitisPancreatitis
Pancreatitis
Raparin University
 
Acute abdomen
Acute abdomenAcute abdomen
Acute abdomen
Fares Dubaea
 
Case summary : Pancreatitis
Case summary : PancreatitisCase summary : Pancreatitis
Case summary : PancreatitisDr Nazeera
 
Acute pain abdomen
Acute pain abdomenAcute pain abdomen
Acute pain abdomen
Varun Karri
 
appendicitis
appendicitisappendicitis
appendicitis
Sumer Yadav
 
Peptic ulcer disease
Peptic ulcer diseasePeptic ulcer disease
Peptic ulcer disease
Michael Edward
 
Case Write Up Surgical Gastric Carcinoma
Case Write Up Surgical Gastric CarcinomaCase Write Up Surgical Gastric Carcinoma
Case Write Up Surgical Gastric Carcinoma
Dr Slayer
 
RAP
RAPRAP
Manifestations Of Gastrointestinal Diseases Copy
Manifestations Of  Gastrointestinal  Diseases    CopyManifestations Of  Gastrointestinal  Diseases    Copy
Manifestations Of Gastrointestinal Diseases CopyMD Specialclass
 
Manifestations of gastrointestinal diseases copy
Manifestations of gastrointestinal diseases   copyManifestations of gastrointestinal diseases   copy
Manifestations of gastrointestinal diseases copyMD Specialclass
 
Manifestations Of Gastrointestinal Diseases Copy
Manifestations Of Gastrointestinal Diseases   CopyManifestations Of Gastrointestinal Diseases   Copy
Manifestations Of Gastrointestinal Diseases CopyMD Specialclass
 
Acute pyelonephritis case
Acute pyelonephritis caseAcute pyelonephritis case
Acute pyelonephritis case
ronerahman
 
acute pancreatitis.ppt
acute pancreatitis.pptacute pancreatitis.ppt
acute pancreatitis.ppt
Subi Babu
 
3rd year lecture acute abdomen.pptx
3rd year lecture acute abdomen.pptx3rd year lecture acute abdomen.pptx
3rd year lecture acute abdomen.pptx
Humera Altaf
 
101104 abdominal pain
101104 abdominal pain101104 abdominal pain
101104 abdominal paincooken
 
Approach to abdominal pain
Approach to abdominal painApproach to abdominal pain
Approach to abdominal pain
Zaheen Zehra
 
Peptic ulcer disease/ Epigastric pain
Peptic ulcer disease/ Epigastric painPeptic ulcer disease/ Epigastric pain
Peptic ulcer disease/ Epigastric pain
Selvaraj Balasubramani
 
Take home-exam (1)
Take home-exam (1)Take home-exam (1)
Take home-exam (1)
TarekWaleed1
 
Acute Abdominal Pain MS-General surgery lecture.ppt
Acute Abdominal Pain MS-General  surgery lecture.pptAcute Abdominal Pain MS-General  surgery lecture.ppt
Acute Abdominal Pain MS-General surgery lecture.ppt
omkarnunna1
 

Similar to acutepancreatitis-231026214130-e9413a87.pdf (20)

Pancreatitis
PancreatitisPancreatitis
Pancreatitis
 
Acute abdomen
Acute abdomenAcute abdomen
Acute abdomen
 
Case summary : Pancreatitis
Case summary : PancreatitisCase summary : Pancreatitis
Case summary : Pancreatitis
 
Acute pain abdomen
Acute pain abdomenAcute pain abdomen
Acute pain abdomen
 
appendicitis
appendicitisappendicitis
appendicitis
 
Peptic ulcer disease
Peptic ulcer diseasePeptic ulcer disease
Peptic ulcer disease
 
Case Write Up Surgical Gastric Carcinoma
Case Write Up Surgical Gastric CarcinomaCase Write Up Surgical Gastric Carcinoma
Case Write Up Surgical Gastric Carcinoma
 
RAP
RAPRAP
RAP
 
Manifestations Of Gastrointestinal Diseases Copy
Manifestations Of  Gastrointestinal  Diseases    CopyManifestations Of  Gastrointestinal  Diseases    Copy
Manifestations Of Gastrointestinal Diseases Copy
 
Manifestations of gastrointestinal diseases copy
Manifestations of gastrointestinal diseases   copyManifestations of gastrointestinal diseases   copy
Manifestations of gastrointestinal diseases copy
 
Manifestations Of Gastrointestinal Diseases Copy
Manifestations Of Gastrointestinal Diseases   CopyManifestations Of Gastrointestinal Diseases   Copy
Manifestations Of Gastrointestinal Diseases Copy
 
Acute pyelonephritis case
Acute pyelonephritis caseAcute pyelonephritis case
Acute pyelonephritis case
 
acute pancreatitis.ppt
acute pancreatitis.pptacute pancreatitis.ppt
acute pancreatitis.ppt
 
3rd year lecture acute abdomen.pptx
3rd year lecture acute abdomen.pptx3rd year lecture acute abdomen.pptx
3rd year lecture acute abdomen.pptx
 
101104 abdominal pain
101104 abdominal pain101104 abdominal pain
101104 abdominal pain
 
Approach to abdominal pain
Approach to abdominal painApproach to abdominal pain
Approach to abdominal pain
 
acute abdomen
acute abdomenacute abdomen
acute abdomen
 
Peptic ulcer disease/ Epigastric pain
Peptic ulcer disease/ Epigastric painPeptic ulcer disease/ Epigastric pain
Peptic ulcer disease/ Epigastric pain
 
Take home-exam (1)
Take home-exam (1)Take home-exam (1)
Take home-exam (1)
 
Acute Abdominal Pain MS-General surgery lecture.ppt
Acute Abdominal Pain MS-General  surgery lecture.pptAcute Abdominal Pain MS-General  surgery lecture.ppt
Acute Abdominal Pain MS-General surgery lecture.ppt
 

Recently uploaded

Physiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of TastePhysiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of Taste
MedicoseAcademics
 
Knee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdfKnee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdf
vimalpl1234
 
Prix Galien International 2024 Forum Program
Prix Galien International 2024 Forum ProgramPrix Galien International 2024 Forum Program
Prix Galien International 2024 Forum Program
Levi Shapiro
 
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
kevinkariuki227
 
263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,
sisternakatoto
 
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTSARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
Dr. Vinay Pareek
 
Evaluation of antidepressant activity of clitoris ternatea in animals
Evaluation of antidepressant activity of clitoris ternatea in animalsEvaluation of antidepressant activity of clitoris ternatea in animals
Evaluation of antidepressant activity of clitoris ternatea in animals
Shweta
 
heat stroke and heat exhaustion in children
heat stroke and heat exhaustion in childrenheat stroke and heat exhaustion in children
heat stroke and heat exhaustion in children
SumeraAhmad5
 
24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all
DrSathishMS1
 
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidadeNovas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Prof. Marcus Renato de Carvalho
 
ACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIOND
ACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIONDACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIOND
ACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIOND
DR SETH JOTHAM
 
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
VarunMahajani
 
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdfARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
Anujkumaranit
 
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness JourneyTom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
greendigital
 
Cervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptxCervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptx
Dr. Rabia Inam Gandapore
 
New Drug Discovery and Development .....
New Drug Discovery and Development .....New Drug Discovery and Development .....
New Drug Discovery and Development .....
NEHA GUPTA
 
Ocular injury ppt Upendra pal optometrist upums saifai etawah
Ocular injury  ppt  Upendra pal  optometrist upums saifai etawahOcular injury  ppt  Upendra pal  optometrist upums saifai etawah
Ocular injury ppt Upendra pal optometrist upums saifai etawah
pal078100
 
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...
GL Anaacs
 
Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...
Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...
Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...
Savita Shen $i11
 
POST OPERATIVE OLIGURIA and its management
POST OPERATIVE OLIGURIA and its managementPOST OPERATIVE OLIGURIA and its management
POST OPERATIVE OLIGURIA and its management
touseefaziz1
 

Recently uploaded (20)

Physiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of TastePhysiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of Taste
 
Knee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdfKnee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdf
 
Prix Galien International 2024 Forum Program
Prix Galien International 2024 Forum ProgramPrix Galien International 2024 Forum Program
Prix Galien International 2024 Forum Program
 
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
 
263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,
 
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTSARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
 
Evaluation of antidepressant activity of clitoris ternatea in animals
Evaluation of antidepressant activity of clitoris ternatea in animalsEvaluation of antidepressant activity of clitoris ternatea in animals
Evaluation of antidepressant activity of clitoris ternatea in animals
 
heat stroke and heat exhaustion in children
heat stroke and heat exhaustion in childrenheat stroke and heat exhaustion in children
heat stroke and heat exhaustion in children
 
24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all24 Upakrama.pptx class ppt useful in all
24 Upakrama.pptx class ppt useful in all
 
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidadeNovas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
 
ACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIOND
ACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIONDACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIOND
ACUTE SCROTUM.....pdf. ACUTE SCROTAL CONDITIOND
 
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
 
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdfARTIFICIAL INTELLIGENCE IN  HEALTHCARE.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdf
 
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness JourneyTom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
 
Cervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptxCervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptx
 
New Drug Discovery and Development .....
New Drug Discovery and Development .....New Drug Discovery and Development .....
New Drug Discovery and Development .....
 
Ocular injury ppt Upendra pal optometrist upums saifai etawah
Ocular injury  ppt  Upendra pal  optometrist upums saifai etawahOcular injury  ppt  Upendra pal  optometrist upums saifai etawah
Ocular injury ppt Upendra pal optometrist upums saifai etawah
 
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...
 
Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...
Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...
Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...
 
POST OPERATIVE OLIGURIA and its management
POST OPERATIVE OLIGURIA and its managementPOST OPERATIVE OLIGURIA and its management
POST OPERATIVE OLIGURIA and its management
 

acutepancreatitis-231026214130-e9413a87.pdf

  • 1. Scenario One WHILE WORKING IN THE ED, A 45-YEAR-OLD MALE PRESENTS WITH ABDOMINAL PAIN. HE DESCRIBES THE ABDOMINAL PAIN AS “SEVERE” AND GRADED IT A 7/10. THERE’S BEEN ASSOCIATED EPISODES OF NAUSEA AND VOMITING. HE MENTIONS THE PAIN RADIATED TO THE BACK BUT GETS BETTER WHEN HE LEANS FORWARD. HE HAD JUST RETURNED FROM A PARTY THE NIGHT BEFORE WHERE HE HAD CONSUMED QUITE A LOT OF LAGERS. ON EXAMINATION, THERE WAS EPIGASTRIC TENDERNESS, AND A PURPLE DISCOLORATION AROUND THE PERIUMBILICAL REGION.
  • 2. Scenario Two  While in the ED, a 50-year-old female presents with sudden onset abdominal pain. She mentions she felt warm to touch and her partner had noticed her eyes looked a bit yellow.  She had taken paracetamol to help with the pain, but it wasn’t helping. She explained that the pain seemed to be worse after eating meals.  On examination, there was epigastric pain, radiating to the back, sclerus icterus, and a temperature of 37.9
  • 3. Acute Pancreatitis By Dr. Gboneme Sandra Junior Clinical Fellow in Medicine George Eliot NHS Trust
  • 4. Outline  Introduction  Theory  Etiology  History and Exam  Investigations  Criteria  Treatment options  Differentials  Summary  Questions ?
  • 5. Introduction  Acute Pancreatitis is an acute inflammation and hemorrhaging of the pancreas due to its own digestive enzymes.  It is a common cause of acute abdominal pain .  Grouped into Mild, Moderate, Severe  Mild: No systemic complications , or organ involvement  Moderate; associated systemic complications or transient organ failure, resolves in 48 hours .  Severe: resolves in greater than 48 hours.
  • 6. Theory  Pancreas is located retroperitoneally in the epigastric region.  Pancreas plays both endocrine and exocrine role;  Exocrine role: Acinar cells produce digestive enzymes that help digest food  The pancreas protects itself by producing enzymes in their inactive form  These enzymes are called zymogens/tripsinogen and are kept in zymogen granules.  Usually, zymogens are activated by Proteases.
  • 7. Etiology Alcohol misuse Gallstone migration Middle aged women Young to middle aged men Hypertriglycerides Use of causative drugs Trauma Hypercalcemia Mumps Family history of pancreatitis Autoimmune Conditions Pancreatic Cancer
  • 8. History and Examination  Mid-Epigastric Pain or Left upper quadrant pain radiating to the back  Nausea and Vomiting  Signs of hypovolemia ( decreased skin turgor, hypotension, oliguria)  Signs of pleural effusion 9especially due to pulmonary dysfunction)  Anorexia/ Lack of appetite  ABDOMINAL EXAM: Tender abdomen with voluntary guarding  Signs of SIRS: Tachypnoea, tachycardia, temperature spikes  Jaundice  Cullen’s/Grey turner sign
  • 9.
  • 10. Investigations  SERUM TRYPSIN: Most accurate but not routinely available  LIPASE  AMYLASE  ROUTINE BLOODS; FBC, U and E, LFT, CRP  Calcium: Hypercalcemia and Hypocalcemia  Serum Triglycerides ( if not gallstone or alcohol ) consider if >11.3 mmol  IMAGING; Contrast Enhanced CT Abdo ( not necessary for diagnosis)
  • 11. Bedside Index of Severity in Acute Pancreatitis (BISAP) Score  BUN > 8.9mmol/L (1 point)  Abnormal mental status with a GCS of <15 (1 point)  Evidence of SIRS (1 point )  Patient age > 60 years old ( 1 point)  Imaging Study reveals pleural effusion ( 1 point )  0 to 2 points: Lower Mortality  3 to 5 points: Higher Mortality
  • 13. Treatment  ABC of Resuscitation  FLUID RESUSCITATION  Pain control  Antiemetic  Alcohol related: Replace Thiamine and other vitamins  Antibiotics if infection is implicated  Early nutritional support, parenteral if neccessary
  • 14. Differentials  PUD  Intestinal obstruction  Cholecystitis  Hepatitis
  • 15. Summary  In Summary, Acute pancreatitis is a common presentation in the ED, and is one that should not be missed.  It requires a high index of suspicion with alcohol and gallstones being the most common causes .  With regards to investigations; Serum Lipase/Amylase is the key investigation and tends to be 3x the higher normal  Fluid resuscitation is important, as well as pain control.
  • 16. Scenario three  A 60-year-old man comes to the emergency complaining of severe epigastric abdominal pain that radiates to the back. Pain improves when he leans forward. It is worse when he breathes in deeply. He also complains of nausea, vomiting and loss of appetite. He smokes 10 cigarettes and drinks 14 units of alcohol per day.  On examination, he has tachycardia, tachypnoea and low blood pressure. There are decreased breath sounds over the base of his left lung.  His routine Bloods showed: BUN 9.9mmol, WBC; 14,000, CRP: 117, Neut: 11,000, adjusted calcium: 2.0  What is his BISAP score ?  What extra tests would you request?  What management would you recommend ?