The document discusses how the early church was led by the Holy Spirit following Pentecost. It describes how the Spirit guided the church through persecution, in reaching Gentiles like Cornelius, and in establishing the church in Antioch. It emphasizes that the Spirit continues to lead both individuals and leaders today, and urges believers to offer their lives as living sacrifices in being transformed by the renewing of their minds to understand God's will. The early church leaders responded to the Spirit's leading by sending Barnabas to preach, and were empowered to spread the gospel message.