The document discusses the integration of Lean Manufacturing and Six Sigma (Lean Six Sigma) and its application in Greek companies. It first reviews the development of Lean and Six Sigma approaches individually. It then examines the combination of Lean and Six Sigma into Lean Six Sigma, highlighting barriers and critical success factors. The research found low awareness of Lean Six Sigma in Greek enterprises and academia. While training is offered, simply training professionals may not ensure effective application in organizations. The document recommends a conceptual framework incorporating characteristics of learning organizations and knowledge management, combined with a strategic quality plan for Greece, to effectively apply Lean Six Sigma.