Slides with topics that are covered and were tested in the recent Absite exams. Nir Hus MD., PhD. http://www.nirhus.com

1. Absite Topic Review
General Surgery
Nir Hus, MD, PhD.
Mount Sinai Medical Center
Miami Beach

2. Transplantation

3. Q1 – Two weeks s/p renal transplant, a pt. developes res.
Insufficiency requiring adm. To ICU. CXR shows diffuse
infiltrates & BAL show cells w/ inclusion bodies. The most
appropriate therapy is:
A. Gangcyclvir
B. Acyclovir
C. Bactrim
D. PCN

4. Q2 – Hyperacute rejection following organ trans. Is most
often due:
A. ABO incompatibility
B. Rh incompatibility
C. Previously sensitized T cells
D. Macrophages

5. Q3 – Hyperacute rejection is an example of hypersensitivity
reaction type:
A. Type I
B. Type II
C. Type III
D. Type IV

6. Q4 – Successful Tx of hyperacute rejection usually involves
A. Steroids
B. Removal of the organ & re-trans.
C. OKT3
D. Rapamycin

7. Q5 – The machanism of cyclosporin is:
A. Binds FK binding protein
B. Binds cyclophilin protein
C. Inhibits purine synthesis by way of 6-
mercaptopurine intermidiate.
D. Binds antigen on T cells

8. Q6 - The mechanism of azathioprine is:
A. Binds FK binding protein
B. Binds cyclophilin protein
C. Inhibits purine synthesis by way of 6-
mercaptopurine intermidiate.
D. Binds antigen on T cells

9. Q7 – The most common malignancy following
transplantation is:
A. Lung CA
B. Prostate CA
C. Breast CA
D. Skin CA

10. Q8 – A positive cross-match means:
A. There are no immunologic problems so one
may proceed w/ the trans.
B. Will likely result in only mild rejection
sometimes after the 1st week.
C. The recipient has preformed AB to donor Ag.
D. Both the donor and recipient are CMV positive.

11. Q9 – A cross-match is performed by:
A. Mixing donor lymphocytes w/ recipient
serum
B. Mixing recipient lymphocytes w/ donor
serum
C. Mixing donor plasma w/ recipient serum
D. Mixing recipient plasma w/ donor serum.

12. Q10 – Post-transplant lymphoproliferative disorder has
been most commonly linked to:
A. HSV
B. RSV
C. EBV
D. Influenza viruses

13. Q11 - A 35 yo man POD#6 from a cadaveric renal trans.
Developes a rise in Cr. The most appropriate next step is:
A. Emergent reop
B. Angiography
C. OKT3
D. US

14. Q12 – in the previous pt. the US shows flow acceleration
of the renal artery. The next appropriate step is:
A. Emergent reop
B. Angiography
C. OKT3
D. US

15. Q13 – in the previous pt. the US is normal. The next
appropriate step is:
A. Emergent reop
B. Angiography
C. OKT3
D. Biopsy

16. Q14 - in the previous pt. the Bx. shows acute
tubulitis. This is consistent w/:
A. Acute rejection
B. UTI
C. Chronic rejection
D. Renal vein thrombosis.

17. Q15 – New proteinnuria in a pt. following renal trans. Is
most consistent w/:
A. Acute rejection
B. UTI
C. Chronic rejection
D. Renal vein thrombosis.

18. Q16 – Most common cause of acute death in a living
related renal trans. Is:
A. PE
B. Hemorrhage
C. MI
D. Infection

19. Q17 – Most common cause of acute death following renal
trans. In a recipient is:
A. PE
B. Hemorrhage
C. MI
D. Infection