This very short document does not contain enough meaningful information to summarize in 3 sentences or less. The document consists of random letters and formatting characters without any discernible topic, details, or narrative to effectively summarize.
This very short document does not contain enough meaningful information to summarize in 3 sentences or less. It only includes repeated letters with no context.
Este documento anuncia el programa de radio "Experiencias Pedagógicas" que se transmitirá el domingo 15 de diciembre de 2013. El tema a discutir será "El reconocimiento de premios y estímulos a los docentes y su implicancia en el desarrollo de la autoestima profesional". Expertos como el Dr. Leon Trahtemberg y la Hermana Shona participarán vía telefónica. Los oyentes podrán interactuar llamando por teléfono o enviando comentarios al blog o dirección indicados.
El documento presenta el Programa Nacional de Cooperación Internacional No Reembolsable (PRONACINR) del Perú, el cual recoge las necesidades de cooperación internacional no reembolsable de las diferentes instituciones públicas a nivel nacional, regional y local. El PRONACINR servirá como instrumento para la gestión y negociación de la cooperación internacional no reembolsable con donantes externos, alineando la demanda identificada con las prioridades nacionales de desarrollo establecidas en la Política Nacional de Cooperación Técnica Internacional y el
The document is a report from Pop Tart Cat Parking containing information about parking orders at the airport location. It lists 5 orders on the same date for a customer named er er with the phone number (123) 123-1231. Each order was for a single parking pass with a total of $14.56 and included additional fees like a $4 service fee. The total for all 5 orders came to $72.82 with extra fees bringing the total amount due to $41.97.
Este documento presenta una guía de aprendizaje para la asignatura de Economía y Política en undécimo grado. La guía se enfoca en la unidad de aprendizaje sobre el comercio internacional durante 10 horas. Incluye competencias, actividades, evaluación y recursos. La evaluación medirá la comprensión de los estudiantes sobre el comercio internacional, las teorías que lo explican y las ventajas y desventajas de los tratados de libre comercio.
This very short document does not contain enough meaningful information to summarize in 3 sentences or less. The document consists of random letters and formatting characters without any discernible topic, details, or narrative to effectively summarize.
This very short document does not contain enough meaningful information to summarize in 3 sentences or less. It only includes repeated letters with no context.
Este documento anuncia el programa de radio "Experiencias Pedagógicas" que se transmitirá el domingo 15 de diciembre de 2013. El tema a discutir será "El reconocimiento de premios y estímulos a los docentes y su implicancia en el desarrollo de la autoestima profesional". Expertos como el Dr. Leon Trahtemberg y la Hermana Shona participarán vía telefónica. Los oyentes podrán interactuar llamando por teléfono o enviando comentarios al blog o dirección indicados.
El documento presenta el Programa Nacional de Cooperación Internacional No Reembolsable (PRONACINR) del Perú, el cual recoge las necesidades de cooperación internacional no reembolsable de las diferentes instituciones públicas a nivel nacional, regional y local. El PRONACINR servirá como instrumento para la gestión y negociación de la cooperación internacional no reembolsable con donantes externos, alineando la demanda identificada con las prioridades nacionales de desarrollo establecidas en la Política Nacional de Cooperación Técnica Internacional y el
The document is a report from Pop Tart Cat Parking containing information about parking orders at the airport location. It lists 5 orders on the same date for a customer named er er with the phone number (123) 123-1231. Each order was for a single parking pass with a total of $14.56 and included additional fees like a $4 service fee. The total for all 5 orders came to $72.82 with extra fees bringing the total amount due to $41.97.
Este documento presenta una guía de aprendizaje para la asignatura de Economía y Política en undécimo grado. La guía se enfoca en la unidad de aprendizaje sobre el comercio internacional durante 10 horas. Incluye competencias, actividades, evaluación y recursos. La evaluación medirá la comprensión de los estudiantes sobre el comercio internacional, las teorías que lo explican y las ventajas y desventajas de los tratados de libre comercio.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition