As we understand more about the human body and how it functions and degrades, biotechnology will progress. This is only the beginning, but when new technology and procedures become accessible, certain themes will start to develop in biopharma trends.
Companies, organizations, and research institutes that are committed to bettering the lives of living organisms fall under the umbrella term known as the life sciences industry. Pharmaceuticals, biotechnology, environmental sciences, biomedicine, nutraceuticals, neurology, cell biology, biophysics, and a lot of other subfields might be classified as some of the different subfields that fall under the umbrella of the life sciences business.
When the Human Genome Project was declared complete back in 2003, there were high expectations set for genomic medicine. However, it has taken over a decade to begin moving from vision to reality. Today, the number of success stories remains relatively small, but they do stretch across the healthcare ecosystem, incorporating the prediction of drug responses, the diagnosis of diseases and the identification of targeted therapies. Stakeholders ranging from patients, healthcare providers and payers, researchers, diagnostic companies, policy-makers, life sciences businesses and governments now believe genomic medicine to be a potential game-changer
Precision medicine is an emerging strategy that considers individual variability in genes, environment, and lifestyle to diagnose, treat, forecast, and prevent disease. As regulatory health authorities begin to develop clearer regulatory pathways in precision medicine, industries must prepare to swiftly adopt to any regulatory changes. This white paper aims to provide a broad overview on the following key topics in precision medicine:
1. Genomics and Pharmacogenetics
2. Precision Medicine vs Personalized Medicine
3. Foundation of Precision Medicine as A Treatment Tool
4. Examples of Precision Medicine as A Treatment, Predictive, and Preventative Tool
5. Precision Medicine and Cancer
6. Challenges, Next Step & Opportunities in Precision Medicine
7. Regulatory insight on Precision medicine
Pharmaceutical Industry's Role in Advancing Precision MedicineClinosolIndia
The pharmaceutical industry plays a pivotal role in driving advancements in precision medicine, a revolutionary approach that tailors medical treatment to individual patient characteristics. By leveraging cutting-edge technologies, conducting innovative research, and collaborating with diverse stakeholders, the pharmaceutical sector contributes significantly to the development and implementation of precision medicine, ushering in a new era of personalized healthcare.
Companies, organizations, and research institutes that are committed to bettering the lives of living organisms fall under the umbrella term known as the life sciences industry. Pharmaceuticals, biotechnology, environmental sciences, biomedicine, nutraceuticals, neurology, cell biology, biophysics, and a lot of other subfields might be classified as some of the different subfields that fall under the umbrella of the life sciences business.
When the Human Genome Project was declared complete back in 2003, there were high expectations set for genomic medicine. However, it has taken over a decade to begin moving from vision to reality. Today, the number of success stories remains relatively small, but they do stretch across the healthcare ecosystem, incorporating the prediction of drug responses, the diagnosis of diseases and the identification of targeted therapies. Stakeholders ranging from patients, healthcare providers and payers, researchers, diagnostic companies, policy-makers, life sciences businesses and governments now believe genomic medicine to be a potential game-changer
Precision medicine is an emerging strategy that considers individual variability in genes, environment, and lifestyle to diagnose, treat, forecast, and prevent disease. As regulatory health authorities begin to develop clearer regulatory pathways in precision medicine, industries must prepare to swiftly adopt to any regulatory changes. This white paper aims to provide a broad overview on the following key topics in precision medicine:
1. Genomics and Pharmacogenetics
2. Precision Medicine vs Personalized Medicine
3. Foundation of Precision Medicine as A Treatment Tool
4. Examples of Precision Medicine as A Treatment, Predictive, and Preventative Tool
5. Precision Medicine and Cancer
6. Challenges, Next Step & Opportunities in Precision Medicine
7. Regulatory insight on Precision medicine
Pharmaceutical Industry's Role in Advancing Precision MedicineClinosolIndia
The pharmaceutical industry plays a pivotal role in driving advancements in precision medicine, a revolutionary approach that tailors medical treatment to individual patient characteristics. By leveraging cutting-edge technologies, conducting innovative research, and collaborating with diverse stakeholders, the pharmaceutical sector contributes significantly to the development and implementation of precision medicine, ushering in a new era of personalized healthcare.
Here are 15 Biopharma research trends to watch in 2023; 1. Epitranscriptomics 2. mRNA vaccines and RNA therapies 3. Drug development using deep learning and large datasets 4. Neoantigens 5. Targeting RNA with small molecules 6. Theranostics 7. Exosomes 8. Synthetic Biology 9. Gene Editing 10. Antibiotics “anti-trend” 11. Nanotechnologies in Drug Delivery 12. Aging research 13. 3-D Bioprinting 14. Microbiome 15. Protein Degraders
The Pharma 2020 series
The Pharmaceutical industry's long successful strategy of placing big bets on a few molecules, promoting them heavily and turning them into blockbusters worked well for many years, but its R&D productivity has now plummeted and the environment’s changing. PwC believes that seven major trends are reshaping the marketplace:
Source of info:
http://www.pwc.com/gx/en/pharma-life-sciences/pharma2020/index.jhtml#
The Significance of Lifescience- An In-depth Exploration.pdfhealthcare360social
Lifescience, an expansive and dynamic domain, unveils the enigmas of living organisms and their intricate connections with the environment. Its impact spans from molding pivotal medical advancements to influencing initiatives in conservation.
Make DNA data actionable - Festival of Genomics London 2018Omar Fogliadini
Consumers are looking for more control over their own health and healthcare, and with the advent of affordable genetic testing there are new avenues for personalised treatment and precision medicine.
As consumer tests come to the fore and patients arrive at their doctor appointments brandishing their own genetic data and full of questions and opinions. Concerns still remain that patients – and not a few physicians – don't always understand what the genetic results mean and just what to do about them. But as consumers get more comfortable with those companies' offerings, the visits with their doctors are often getting more complex.
With the increased use of the Internet for medical information, consumers have become medical consumers not just patients This has created a change in the doctor/patient relationship as individuals become more knowledgeable about their own health and want more control over their personal information and treatment decisions. Physicians, meanwhile, are concerned about giving patients too much access to information they may not properly understand. Even many doctors aren't well-trained in the clinical implications of genetics and genomics.
The CMO’s Generation Genome report is focused on the need for the UK to maintain its presence as a world leader in genomic medicine. It presented a vision of genomics being integrated into the NHS within the next 5 years.
The “vast majority” of NHS doctors are “not up to speed” with modern genetic techniques that can transform patients’ chances.
GENOMIC INTELLIGENCE
Suisse Life Science specialiSes in making DNA data useful for population health management.
Using our flagship Scienceof[DNA]f(x) technology, Suisse Life Science Group can provide you with an evidence-based lifestyle behavioural medicine dynamic system based on the associated genetic variants supported by literature citations for health, wellness or chronic diseases, and customised around your needs.
What used to take weeks of painstaking manual curation can now be completed in days.
PERSONALISED HEALTH TECHNOLOGY FOR GENOMIC COMPANIES OR CUSTOM APPLICATIONS
We help companies by providing a comprehensive nutritional, metabolic and lifestyle analysis and management program that includes nutrition intake and lifestyle monitoring, followed by a personalised nutritional, chronic disease prevention and sport recommendations, tailored for the user, informed on their biomarkers but updated - in real-time - with life data from consumer devices (smartphones, wearables…).
Ready-to-market technology.
Ask for a demo at info@suisselifescience.com
Emerging Technologies Shaping the Future of Precision MedicineClinosolIndia
Precision medicine, with its focus on tailoring healthcare interventions to individual characteristics, is undergoing a transformative evolution propelled by emerging technologies. From advanced genomic tools to artificial intelligence, these technologies are revolutionizing our ability to understand, diagnose, and treat diseases at an unprecedented level of specificity. This article explores the key emerging technologies shaping the future of precision medicine.
How Artificial Intelligence in Transforming PharmaTyrone Systems
Artificial intelligence in Pharma refers to the use of automated algorithms to perform tasks which traditionally rely on human intelligence. Over the last five years, the use of artificial intelligence in the pharma and biotech industry has redefined how scientists develop new drugs, tackle disease, and more.
Given the growing importance of Artificial Intelligence for the pharma industry, we wanted to create a comprehensive report which helps every business leader understand the biggest breakthroughs in the biotech space which are assisted by the deployment of artificial intelligence technologies.
The Role of Artificial Intelligence and Machine Learning in Clinical Research...ClinosolIndia
Artificial Intelligence (AI) and Machine Learning (ML) have emerged as powerful tools with immense potential to transform various aspects of clinical research and pharmacovigilance. This paper explores the role of AI and ML in these fields, highlighting their applications, benefits, and challenges.
In clinical research, AI and ML offer significant advancements in data analysis, patient stratification, and decision support. These technologies can efficiently process large volumes of clinical data, including electronic health records, genomic data, medical imaging, and clinical trial data, to identify patterns, predict outcomes, and generate actionable insights.
One major application of AI and ML in clinical research is patient stratification and personalized medicine. These technologies can analyze patient data to identify subgroups with specific characteristics or treatment responses. By understanding these subgroups, researchers can design more targeted clinical trials, identify appropriate patient populations for specific interventions, and develop personalized treatment approaches.
Additionally, AI and ML can aid in the identification of potential therapeutic targets, prediction of treatment responses, and optimization of clinical trial designs. These technologies can analyze complex datasets, uncover hidden correlations, and generate hypotheses that can guide researchers in their investigations. Furthermore, AI and ML can assist in adverse event prediction and monitoring, aiding in early detection and intervention.
In the field of pharmacovigilance, AI and ML have the potential to revolutionize adverse event detection, signal generation, and signal validation. These technologies can process large volumes of real-world data, including electronic health records, social media, and spontaneous reporting systems, to identify potential safety concerns associated with medications. AI and ML algorithms can detect patterns, associations, and unexpected relationships between drugs and adverse events, enabling proactive pharmacovigilance activities.
The integration of AI and ML in pharmacovigilance also facilitates signal validation and risk assessment. These technologies can analyze diverse data sources, identify potential signals, and prioritize them based on their significance and impact. By automating certain aspects of signal validation, AI and ML can streamline the pharmacovigilance process, allowing for more efficient and timely identification and management of drug safety concerns.
Best of 5 regenerative medicine companies 2021 Merry D'souza
Best of 5 Regenerative Medicine Companies, we came across innovative companies that are ceaselessly striving to deliver the best therapeutic provisions rooting from strong research & development.
Deep Leg Vein Thrombosis (DVT): Meaning, Causes, Symptoms, Treatment, and Mor...The Lifesciences Magazine
Deep Leg Vein Thrombosis occurs when a blood clot forms in one or more of the deep veins in the legs. These clots can impede blood flow, leading to severe complications.
Dengue Fever Outbreak: Cases Reported in Alabama, Florida, and Georgia | The ...The Lifesciences Magazine
Dengue fever, a mosquito-borne viral infection, has been confirmed in Alabama, Florida, and Georgia, according to recent reports. Dengue fever presents a range of symptoms, including high fever, severe headaches, eye pain.
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Here are 15 Biopharma research trends to watch in 2023; 1. Epitranscriptomics 2. mRNA vaccines and RNA therapies 3. Drug development using deep learning and large datasets 4. Neoantigens 5. Targeting RNA with small molecules 6. Theranostics 7. Exosomes 8. Synthetic Biology 9. Gene Editing 10. Antibiotics “anti-trend” 11. Nanotechnologies in Drug Delivery 12. Aging research 13. 3-D Bioprinting 14. Microbiome 15. Protein Degraders
The Pharma 2020 series
The Pharmaceutical industry's long successful strategy of placing big bets on a few molecules, promoting them heavily and turning them into blockbusters worked well for many years, but its R&D productivity has now plummeted and the environment’s changing. PwC believes that seven major trends are reshaping the marketplace:
Source of info:
http://www.pwc.com/gx/en/pharma-life-sciences/pharma2020/index.jhtml#
The Significance of Lifescience- An In-depth Exploration.pdfhealthcare360social
Lifescience, an expansive and dynamic domain, unveils the enigmas of living organisms and their intricate connections with the environment. Its impact spans from molding pivotal medical advancements to influencing initiatives in conservation.
Make DNA data actionable - Festival of Genomics London 2018Omar Fogliadini
Consumers are looking for more control over their own health and healthcare, and with the advent of affordable genetic testing there are new avenues for personalised treatment and precision medicine.
As consumer tests come to the fore and patients arrive at their doctor appointments brandishing their own genetic data and full of questions and opinions. Concerns still remain that patients – and not a few physicians – don't always understand what the genetic results mean and just what to do about them. But as consumers get more comfortable with those companies' offerings, the visits with their doctors are often getting more complex.
With the increased use of the Internet for medical information, consumers have become medical consumers not just patients This has created a change in the doctor/patient relationship as individuals become more knowledgeable about their own health and want more control over their personal information and treatment decisions. Physicians, meanwhile, are concerned about giving patients too much access to information they may not properly understand. Even many doctors aren't well-trained in the clinical implications of genetics and genomics.
The CMO’s Generation Genome report is focused on the need for the UK to maintain its presence as a world leader in genomic medicine. It presented a vision of genomics being integrated into the NHS within the next 5 years.
The “vast majority” of NHS doctors are “not up to speed” with modern genetic techniques that can transform patients’ chances.
GENOMIC INTELLIGENCE
Suisse Life Science specialiSes in making DNA data useful for population health management.
Using our flagship Scienceof[DNA]f(x) technology, Suisse Life Science Group can provide you with an evidence-based lifestyle behavioural medicine dynamic system based on the associated genetic variants supported by literature citations for health, wellness or chronic diseases, and customised around your needs.
What used to take weeks of painstaking manual curation can now be completed in days.
PERSONALISED HEALTH TECHNOLOGY FOR GENOMIC COMPANIES OR CUSTOM APPLICATIONS
We help companies by providing a comprehensive nutritional, metabolic and lifestyle analysis and management program that includes nutrition intake and lifestyle monitoring, followed by a personalised nutritional, chronic disease prevention and sport recommendations, tailored for the user, informed on their biomarkers but updated - in real-time - with life data from consumer devices (smartphones, wearables…).
Ready-to-market technology.
Ask for a demo at info@suisselifescience.com
Emerging Technologies Shaping the Future of Precision MedicineClinosolIndia
Precision medicine, with its focus on tailoring healthcare interventions to individual characteristics, is undergoing a transformative evolution propelled by emerging technologies. From advanced genomic tools to artificial intelligence, these technologies are revolutionizing our ability to understand, diagnose, and treat diseases at an unprecedented level of specificity. This article explores the key emerging technologies shaping the future of precision medicine.
How Artificial Intelligence in Transforming PharmaTyrone Systems
Artificial intelligence in Pharma refers to the use of automated algorithms to perform tasks which traditionally rely on human intelligence. Over the last five years, the use of artificial intelligence in the pharma and biotech industry has redefined how scientists develop new drugs, tackle disease, and more.
Given the growing importance of Artificial Intelligence for the pharma industry, we wanted to create a comprehensive report which helps every business leader understand the biggest breakthroughs in the biotech space which are assisted by the deployment of artificial intelligence technologies.
The Role of Artificial Intelligence and Machine Learning in Clinical Research...ClinosolIndia
Artificial Intelligence (AI) and Machine Learning (ML) have emerged as powerful tools with immense potential to transform various aspects of clinical research and pharmacovigilance. This paper explores the role of AI and ML in these fields, highlighting their applications, benefits, and challenges.
In clinical research, AI and ML offer significant advancements in data analysis, patient stratification, and decision support. These technologies can efficiently process large volumes of clinical data, including electronic health records, genomic data, medical imaging, and clinical trial data, to identify patterns, predict outcomes, and generate actionable insights.
One major application of AI and ML in clinical research is patient stratification and personalized medicine. These technologies can analyze patient data to identify subgroups with specific characteristics or treatment responses. By understanding these subgroups, researchers can design more targeted clinical trials, identify appropriate patient populations for specific interventions, and develop personalized treatment approaches.
Additionally, AI and ML can aid in the identification of potential therapeutic targets, prediction of treatment responses, and optimization of clinical trial designs. These technologies can analyze complex datasets, uncover hidden correlations, and generate hypotheses that can guide researchers in their investigations. Furthermore, AI and ML can assist in adverse event prediction and monitoring, aiding in early detection and intervention.
In the field of pharmacovigilance, AI and ML have the potential to revolutionize adverse event detection, signal generation, and signal validation. These technologies can process large volumes of real-world data, including electronic health records, social media, and spontaneous reporting systems, to identify potential safety concerns associated with medications. AI and ML algorithms can detect patterns, associations, and unexpected relationships between drugs and adverse events, enabling proactive pharmacovigilance activities.
The integration of AI and ML in pharmacovigilance also facilitates signal validation and risk assessment. These technologies can analyze diverse data sources, identify potential signals, and prioritize them based on their significance and impact. By automating certain aspects of signal validation, AI and ML can streamline the pharmacovigilance process, allowing for more efficient and timely identification and management of drug safety concerns.
Best of 5 regenerative medicine companies 2021 Merry D'souza
Best of 5 Regenerative Medicine Companies, we came across innovative companies that are ceaselessly striving to deliver the best therapeutic provisions rooting from strong research & development.
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Deep Leg Vein Thrombosis occurs when a blood clot forms in one or more of the deep veins in the legs. These clots can impede blood flow, leading to severe complications.
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CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
R3 Stem Cells and Kidney Repair A New Horizon in Nephrology.pptxR3 Stem Cell
R3 Stem Cells and Kidney Repair: A New Horizon in Nephrology" explores groundbreaking advancements in the use of R3 stem cells for kidney disease treatment. This insightful piece delves into the potential of these cells to regenerate damaged kidney tissue, offering new hope for patients and reshaping the future of nephrology.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
QA Paediatric dentistry department, Hospital Melaka 2020Azreen Aj
QA study - To improve the 6th monthly recall rate post-comprehensive dental treatment under general anaesthesia in paediatric dentistry department, Hospital Melaka
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
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Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
1. 7 Biopharma Trends to watch in 2023
By The Lifesciences Magazine
As we understand more about the human body and how it functions and
degrades, biotechnology will progress. This is only the beginning, but when
new technology and procedures become accessible, certain themes will
start to develop in biopharma trends.
While biotechnology is undoubtedly a growing sector, there are still many
obstacles that must be conquered in the years ahead if the area is to
continue to be as innovative as it is now. Businesses in the
biopharmaceutical sector will need to innovate, adapt to new technology,
and rebrand if they want to survive.
This year’s list of top biopharma trends for the next decade shows how
technology is altering the way we study, treat, and prevent illness, from
personalized medicine and precision oncology to virtual healthcare.
2. Here are 7 biopharma trends to
watch out for in 2023;
1. Digital Health Technology
The pharmaceutical and biotechnology sectors often inquire as to my
predictions for the development of digital health technologies. There have
been three primary applications of this biopharma trends technology so far:
facilitating better drug adherence, enhancing patient understanding of their
sickness or condition, and strengthening the patient-provider connection.
In response to patients’ growing knowledge of available options, the
pharmaceutical and biotechnology sectors are evolving at a rapid pace.
With the proliferation of smartphones, smartwatches, and other wearables
as well as the rise of the Internet of Things, the market for digital health
technologies has exploded.
In order to keep up with the ever-changing nature of this market, both start-
ups and long-standing businesses are adopting cutting-edge strategies.
These tools have the potential to enhance patient care while reducing
3. healthcare expenditures. They range from innovative medication delivery
technology to clinical trial monitoring systems.
2. Drug Delivery Systems
There are a variety of firms operating in the drug delivery systems industry,
but pharmaceutical and biopharma trends corporations have mostly
dominated this sector due to their extensive investment in research and
development. Drug delivery systems’ main goal is to maximize the effective
administration of medicinal medicines.
With technology’s rising prominence, smart medications are predicted to
become popular, and more effective drug delivery methods will become
readily accessible. Better drug delivery methods with increased delivery,
greater absorption, less adverse effects, and reduced cost are anticipated
from the biotechnology and pharmaceutical sectors of biopharma trends.
The DDS market is expanding and changing all the time. Nanotechnology,
the study of matter at the nanoscale, is now driving the DDS industry.
Scientists now have access to equipment and methods made feasible by
nanotechnology that allowed them to alter matter in ways that were before
inconceivable. These microscopic pieces are of interest to scientists for
several reasons.
Drug delivery, in which nanoparticles are utilized to deliver medication to
targeted parts of the body, is the most common use of nanotechnology.
Targeted delivery through these nanoparticles reduces collateral harm to
healthy tissues while getting the drug where it needs to go.
3. Nanotechnology
Nanotechnology’s potential as a medication delivery system in the
pharmaceutical and biopharma trends industries is growing quickly. By
using nanotechnology, pharmaceutical companies may create medications
that can be delivered to specific organs or tissues, reducing the overall
dose required to achieve the desired effect.
4. Nanoparticles may be tailored for localized delivery to a specific organ or
tissue. This facilitates targeted treatment, in which the drug is administered
precisely where it is needed inside the body. Targeted medicine delivery
has the potential to lessen adverse effects and boost treatment success.
Nanotechnology is a cutting-edge field of study concerned with the tiniest
scales of material manipulation, and it is already finding widespread usage
in a wide variety of modern goods and industries. Studies in the industrial,
medicinal, energy and ecological sectors are all included. Nanomedicine is
an exciting field because many pharmaceuticals are now produced at the
nanoscale.
4. Cellular Therapies
The biopharma trends, cell treatments, and the introduction of therapeutic
cells into a patient to promote tissue regeneration and immune system
repair are other areas of pharmacological research and development.
Research and Markets predict that the cellular therapeutics industry will
expand rapidly during the next five years. Stem cell therapies, bone marrow
transplants, immune cells, and blood cells are all examples of cell-based
medications.
5. There are hundreds of clinical studies now enrolling patients throughout the
globe, but only a small number of cell-based medicines have been given
the green light. Most of these drugs are used in the therapy of various
ailments, most notably cancer and blood problems.
5. Innovative Drug Development
Companies in the pharmaceutical industry invest millions of dollars
attempting to determine which products should be brought to market and
which should be discarded. However, several pharmaceutical firms are
exploring an alternative method of drug development that has the potential
to significantly cut down on the resources typically devoted to bringing
medicine to market.
The Cell Design Suite was developed by a team of academics from
Stanford and UCLA to provide a platform for researchers to generate 3D
models of cells for study. By using this app, researchers may investigate
hundreds of drug compounds and thousands of drug targets, practically
creating their medications and assessing their efficacy in vitro.
Rapid development and alteration characterize the biopharmaceutical
business. Biotechnology and gene therapy are relatively new developments
that are shaking up the market. Every facet of medical practice stands to
6. benefit from advances in biotechnology and molecular pharmaceuticals that
facilitate the discovery and development of new drugs.
New treatments are being developed by the biopharma trends and
pharmaceutical industries, which make use of biological systems including
bacteria, cells, viruses, and even human tissue. Finding novel therapeutic
targets in the human genome using sequencing is becoming more
common. This has resulted in the creation of several novel treatments.
6. Personalized Medicine
Patients aren’t the only ones who can benefit from personalized treatment
any more. The American Society for Clinical Oncology (ASCO) claims that
the pharmaceutical and biopharma trends sectors, including healthcare
systems, hospitals, clinics, pharmacies, insurers, device manufacturers,
and many more, are starting to feel the effects of customized medicine.
At present, customized medicine is emerging as a major trend in the
pharmaceutical sector. Many businesses are now attempting to enhance
pharmacological therapy and individual patient outcomes by using genetic
sequencing, AI, and data science.
Idera Pharmaceuticals is one such business; in April 2018, they announced
the launch of a technology that can sequence patients’ genomes to identify
a molecular target for individualized cancer treatment.
Moreover, P&G has recently used big data and personalized medicine to
discover novel approaches to treating and preventing illness. P&G has
developed pharmaceuticals with unprecedented effectiveness and safety
by combining data from genome sequencing, clinical trials, consumer
surveys, and other medical studies.
7. Stem Cells for the Treatment of
Neurodegenerative Diseases
Many businesses in the pharmaceutical and biopharma trends are looking
at stem cell therapy as a way to find medicines for neurodegenerative
disorders including Parkinson’s and Alzheimer’s. Many of the treatments
being researched and developed use human stem cells, but there are also
animal stem cell-based therapies. In recent years, stem cells have been
employed to treat a broad variety of illnesses.
7. biotechnology sectors
pharmaceutical industry
BOTTOM LINE
Although there have been great strides made in the previous decade, we
are now entering the age of next-generation biopharma trends, biologics
made possible by developments in gene editing, synthetic biology, cell
manufacturing, and new data-driven methods of drug discovery and
development.
Summing up, the biopharma trends sector has become more sophisticated
over the last several years, making it more difficult than ever to maintain a
head start. Pharmaceutical firms, more than ever before, must respond
rapidly to shifting regulatory landscapes, rising demand for innovative
medicines, and growing interest in patient-specific health care. See the top
seven developments that will shape your prospects for success in the year
2022 and beyond