This play follows the drama between friends Latisha, Tasha, Keosha, and Caramel after Latisha discovers that Tasha and her ex Laron kissed. In revenge, Latisha plots with Keosha and Caramel to kill Tasha, which they do. However, Keosha and Caramel then plan to kill Laron without Latisha's permission. Their actions lead to multiple deaths until only Stacy and Curtis remain at the end.
Teri Lee Thompson
Teri's Story
November 30, 1983 - May 7, 2003
By: Becky Kantner and James Kantner
Please immunize your children against meningitis, Ter's brother James was immunized and he can tell you how happy he is to have gotten it done, Teri wasn't...so she can't. I had never really heard of it until my daughter was already gone...Now you know how she died. More importantly I'd love for you to get a peek at how she lived. Lots of Love, ...just me Becky...(the mama)
The weekend starts out as ordinary for Tania and Antwain. Tania gets some good news regarding her photography career and decides that it's due time for a serious discussion with her father.
Tania faces her father, George Jr., but hits a soft spot when she brings up her dead brother. She has a lot to learn when it comes to knowing who her father really is. Her mother, Bianca, steps in to give her a bit of insight on George Jr. 's past.
Teri Lee Thompson
Teri's Story
November 30, 1983 - May 7, 2003
By: Becky Kantner and James Kantner
Please immunize your children against meningitis, Ter's brother James was immunized and he can tell you how happy he is to have gotten it done, Teri wasn't...so she can't. I had never really heard of it until my daughter was already gone...Now you know how she died. More importantly I'd love for you to get a peek at how she lived. Lots of Love, ...just me Becky...(the mama)
The weekend starts out as ordinary for Tania and Antwain. Tania gets some good news regarding her photography career and decides that it's due time for a serious discussion with her father.
Tania faces her father, George Jr., but hits a soft spot when she brings up her dead brother. She has a lot to learn when it comes to knowing who her father really is. Her mother, Bianca, steps in to give her a bit of insight on George Jr. 's past.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
1. Reniece Williams
Prd. O3 O5O8O9
Mr.Wynne ..
Friends, love, and Betrayal
Characters : Latisha Rebecca
Tasha Laron
Keosha Stacy
Kindia Shantele
Curtis
Act 1 Scene 1 :
Narrator : Latisha is on the phone talking to Laron, when Tasha texts her. Latisha gets off the phone and
wonders why Laron is at Tasha’s house.
Latisha : What is Laron doing at your house ?
Tasha : I don’t know, I’m about to find out.
Latisha : Ok
Tasha : Yea
*5 minutes later, Latisha gets a call from Tasha.
Tasha : He came by to get my number and say he likes me.
Latisha : What you told him ?
Tasha : Nothing, just gave him my number and her left.
Latisha : mmhmm .. that’s all ?
Tasha : Yea
Latisha : Ok bye
*hangs up the phone and calls Keosha and Caramel
Caramel : Child more happened than that.
2. Latisha : I don’t know what to believe.
Keosha : Ask her.
Latisha : I did and she said nothing happened but I believe something did.
Caramel : Hold up , I just don’t trust her.
Keosha : Me either.
Latisha : Well I don’t know I’ll talk to yall later. Goodnight.
Keosha and Caramel : Night.
Act 2 Scene 1 :
Narrator : A week later, Stacy went to Latisha’s house with Kindia and Curtis. Stacy was on the couch
talking to Latisha.
Stacy : Hey sis, what’s up ?
Latisha : Hey girl I believe Tasha flaw.
Stacy : Me too, you could see she becoming a lil fake now.
Latisha : Yea well since you close to Laron, did she ever do anything with him ? She said no but I think
she did.
Stacy : I don’t know sis but I could find out.
Latisha : Yea do that and let me know.
Stacy : I got you sis.
*Kindia walks in with Curtis
Kindia : What yall talking bout ?
Latisha : About what I told you last night.
Kindia : Bout Tasha ?
Latisha : Yea
Curtis : What bout her ?
Latisha : Ask your wife, she’ll ..
Rebecca : I can’t stand Tasha and your ex Shantele.
3. Act 2 Scene 2 :
Narrator : Rebecca explains why she doesn’t like Tasha.
Rebecca : Yall need to get yall friend before I do.
Stacy : Man chill out.
Rebecca : Naw I’m tired of her.
Act 2 Scene 3 :
Narrator : Shantele calls Rebecca’s house.
Shantele : You need to leave my girl alone.
Rebecca : Lil girl she aint with you no more, she with me.
Shantele : Kill yourself.
*Hangs up.
Latisha : What’s all the yelling ?
Rebecca : Shantele calling talking stupid.
Latisha : Oh wow.
Act 3 Scene 1 :
Narrator : Latisha, Kindia, Curtis, Rebecca, and Stacy walks in on Tasha and Laron kissing.
Latisha : What are yall doing ?
Laron : Uhm ..
Tasha : He kissed me, I didn’t kiss him.
Latisha : Don’t lie to me your making out with my ex.
Tasha : I didn’t do anything wrong. You like the person I’m in love with.
Latisha : He’s an ex of course I’m going to still have feelings for him.
Laron : I’m sorry, she came on to me.
Tasha : Why are you lying ?
Latisha : Whatever.
4. *Walks out.
Act 4 Scene 1 :
Narrator : Later that day Latisha plots to kill Tasha at a house party.
Latisha : Keosha you remember the plan ?
Keosha : Yea, Caramel in place now.
Latisha : Ok, I’m going to call her.
*Calls Caramel
Latisha : Hey are you ready ?
Caramel : Ready ! I see her do it now.
Latisha : Ok
Act 4 Scene 2 :
Narrator : Latisha holds the knife behind her back while talking to Tasha.
Tasha : Hey Latisha , are you still mad at me ?
Latisha : It’s whatever, do you.
Tasha : I’m truly sorry.
Latisha : It should of never happened.
Tasha : I know.
Latisha : Bye because your getting me mad.
Tasha : How ?
Latisha : Ugh ..
*stabs Tasha, she dies.
Act 4 Scene 3 :
Narrator : Caramel and Keosha walks in.
Caramel : Keosha gets the bag ready to put her in.
Keosha : Got it.
5. Latisha : Why did I kill her ? I regret it.
*Keosha whispers to Caramel.
Latisha : What are yall saying ?
Caramel : Nothing just that Laron is next.
Act 5 Scene 1 :
Narrator : Caramel and Keosha planned on killing Laron without telling Latisha.
Latisha : NO ! You can’t !
Caramel : We have to.
Keosha : Yes we do.
Latisha : I’m not going to let it happen.
Act 5 Scene 2 :
Narrator : Laron is on the balcony where Caramel and Keosha sees him. They shot him and Curtis and
Kindia saw.
Kindia : NO ! Why did you kill him ?
Caramel : Because he’s no good.
Kindia : Ugh .. I’m gonna kill yall .
Act 5 Scene 3 :
Narrator : Kindia chokes Caramel to death and Keosha goes to help her. Kindia grabs the gun.
Keosha : Why do you even care ?
Kindia : Because I love him !
*Shoots Keosha, she dies and Latisha walks in and gets shot in the stomach.
Act 5 Scene 4 :
Kindia : I’m sorry, I didn’t mean to.
*Latisha dies.
Curtis : You shot her ! What do you mean you love him ?
6. Kindia : Yes it’s true, I’m in love with Laron and we bin together for two years now.
Curtis : How could you do this to me ?
Kindia : Boy please, don’t act like things was good between us.
Curtis : Where is all this coming from ?
Kindia : I’m sorry but goodbye.
*Kindia shot Curtis in the arm. Stacy was behind her and shot her.
Stacy : I’m sorry man but she’s crazy.
Curtis : Yea but I love her.
Stacy : * Yells * Somebody call 911, he’s bin shot.
Curtis : Thank you for saving my life.
Stacy : Yea man, it’s straight.