6. FDA since2005
FDA cleared since 2005 as
adjunct to mammography
CE Mark since 2006
Canada since 2007
Taiwan since 2005
7. Density
one of the most significant risk factors r
74% of women between age 40 and
49 years Breast Density 1
4-6x increased risk of breast cancer 2
1. Checka CM, Chun JE, Schnabel FR, Lee J, Toth H. The
relationship of mammographic density and age:
implications for breast cancer screening. AJR Am J
Roentgenol. 2012 Mar;198(3):W292-5.
2. Boyd, Guo, Martin et al. Mammographic Density and the
Risk and Detection of Breast Cancer. NEJM 2007;356:227.
13. X 线摄影
• 钼靶 X 射线摄影能有效降低乳腺癌的死亡
率（ 20%-40% ）
• Sensitivity of Mammography in Dense
Breasts = 65% （漏诊率超过 1/3)
• Mandelson MT, et al.Breast density as a predictor of mammographic detection: comparison of interval- and screen-
detected cancers. J Natl Cancer Inst 2000; 92:1081–1087.
16. X 线摄影
• Women with dense breasts have a 17.8x greater
risk of breast cancer being detected within 12
months after a negative screening mammogram
无早期筛查，查出 BI-RADS 3 或 4a 级别的乳腺癌
将带来严重后果
• 1. Boyd, Guo, Martin et al. Mammographic Density and the Risk and Detection of Breast Cancer. NEJM 2007;356:227.
• 2. Yahgjyan, Colditz, Collins et al. Mammographic Breast Density and Subsequent Risk of Breast Cancer in Postmenopausal Women
According to Tumor Characteristics. 2011. JNCI;103:1179.
18. 超声
• 超声 +X 线摄影可将敏感性提高
至
97%*
（ 65% ）
• * Kolb TM, et.al. Comparison of the performance of screening, mammography,
physical examination and breast US and evaluation of factors that influence
them: An analysis of 27,825patient evaluations. Radiology. 2002;225:165-175.
